Tox3 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:332652 Zhu Q, et al., Decoding anterior-posterior axis emergence among mouse, monkey, and human embryos. Dev Cell. 2023 Jan 9;58(1):63-79.e4
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7581002
Gene symbol:	Tox3
Gene name:	TOX high mobility group box family member 3

Antibody:	anti-TOX3 (HPA040376)
Detection system:	Secondary antibody

Results

Specimen 3K (upper): embryonic day 6.5 (more

)
Note: Double labeled: green - Tox3; red - Cer1 (assay MGI:7581000).

Structure	Level	Pattern	Image	Note
TS9: anterior visceral endoderm	Present	Regionally restricted	3K merge (upper) , 3K inset (upper) , 3K Tox3 (upper)	Expressed specifically in late anterior visceral endoderm (L-AVE), colocalized with Cer1 expression.

Specimen 3K (lower): embryonic day 6.5 (more

)
Note: Double labeled: green - Tox3; red - Dkk1 (assay MGI:7580999).

Structure	Level	Pattern	Image	Note
TS9: anterior visceral endoderm	Present	Regionally restricted	3K merge (lower) , 3K Dkk1/Tox3 , 3K Tox3 (lower) , 3K inset (lower)	Expressed specifically in late anterior visceral endoderm (L-AVE)..

Specimen 3L: embryonic day 5.5 (more

)
Note: Double labeled: green - Tox3; red - Cer1 (assay MGI:7581000).

Structure	Level	Pattern	Image	Note
TS7: anterior visceral endoderm	Present	Regionally restricted	3L merge , 3L inset , 3L Tox3 , 3L Cer1/Tox3	Expression in subgroup within Cer1-expressing cells. Expression in early anterior visceral endoderm (E-AVE) at distal side of embryo.
TS7: posterior visceral endoderm	Absent		3L merge , 3L inset , 3L Tox3 , 3L Cer1/Tox3	No expression in early distal visceral endoderm (E-DVE).

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23