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Gene Expression Data
Assay Details
Assay
Reference: J:286213 Dunty WC Jr, et al., Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/beta-catenin pathway in neuromesodermal stem cells. PLoS One. 2014;9(1):e87018
Assay type: RNA in situ
MGI Accession ID: MGI:7574587
Gene symbol: Sp8
Gene name: trans-acting transcription factor 8
Probe: Sp8 cDNA
Probe preparation: Antisense RNA
Results
Specimen 2F: embryonic day 7.5-7.75 (more )
Structure Level Pattern Image Note
TS11: node Present 2F
TS11: primitive streak Present 2F
Specimen 2G: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: node Present 2G
TS13: primitive streak Present 2G
Specimen 2H: embryonic day 8.5; Wnt3atm1Amc/Wnt3atm1Amc (more )
Structure Level Pattern Image Note
TS13: primitive streak Present 2H Reduced expression compared with the wild-type.
Specimen 2I: embryonic day 8.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: primitive streak Present 2I Reduced expression compared with the wild-type.
Specimen 2J: embryonic day 8.5; Ctnnb1tm1Mmt/Ctnnb1tm1Mmt, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS13: primitive streak Strong 2J Highly up-regulated expression compared with the wild-type.
Specimen 3C: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: primitive streak Strong Widespread 3C
Specimen 3E: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: embryo ectoderm Strong 3E
TS13: embryo mesoderm Present 3E
TS13: neural plate Strong Regionally restricted 3E Highly expressed in the caudal neural plate.
TS13: primitive hindgut Weak Regionally restricted 3E Weakly expressed in the dorsal hindgut.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory