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Gene Expression Data
Assay Details
Assay
Reference: J:209428 Ragancokova D, et al., TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. J Clin Invest. 2014 Mar 3;124(3):1214-27
Assay type: RNA in situ
MGI Accession ID: MGI:7491917
Gene symbol: Prokr2
Gene name: prokineticin receptor 2
Results
Specimen 9B Control: embryonic day 18.5; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Structure Level Pattern Image Note
TS26: rostral migratory stream Present 9B Control
TS26: main olfactory bulb Present Regionally restricted 9B Control Expression restricted to inner layers of olfactory bulb
Specimen 9B Tshz1-/-: embryonic day 18.5; Tshz1tm1Garr/Tshz1tm2.2Garr (more )
Structure Level Pattern Image Note
TS26: rostral migratory stream Trace 9B Tshz1-/- Expression in rostral migratory stream strongly reduced.
TS26: main olfactory bulb Trace 9B Tshz1-/- Expression in inner layers of olfactory bulb strongly downregulated.
Specimen 9C Control: postnatal week 3; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Structure Level Pattern Image Note
TS28: rostral migratory stream Present 9C Control inset , 9C Control
TS28: main olfactory bulb Present Scattered 9C Control inset , 9C Control Expression scattered through granule cell layer in subpopulation of radially migrating neuroblasts.
Specimen 9C coTshz1: postnatal week 3; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: rostral migratory stream Weak Regionally restricted 9C coTshz1 , 9C coTshz1 inset Expression in rostral migratory stream slightly downrugulated
TS28: main olfactory bulb granule cell layer Absent 9C coTshz1 , 9C coTshz1 inset Radially migrating neuroblasts were absent in mutants. No expression in cells outside of rostral migrating stream.
Specimen S8A pSVZ control: postnatal; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb subependymal zone Present Regionally restricted S8A control Expression in cells of subventricular zone.
Specimen S8A pSVZ coTshz1: postnatal; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: main olfactory bulb subependymal zone Present Regionally restricted S8A coTSHZ1 Expression in cells of subventricular zone not affected compared to control.
Specimen S8B aSVZ control: postnatal; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb subependymal zone Present Regionally restricted S8B control Expression in cells of subventricular zone.
Specimen S8B aSVZ coTshz1: postnatal; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: main olfactory bulb subependymal zone Present Regionally restricted S8B coTSHZ1 Expression in cells of subventricular zone not affected compared to control.
Specimen S8C RMS control: postnatal; Tshz1tm1Garr/Tshz1tm2.1Garr (more )
Structure Level Pattern Image Note
TS28: rostral migratory stream Present Regionally restricted S8C control Expression in neuroblasts migrating tangentially with rostral migratory stream.
Specimen S8C RMS coTshz1: postnatal; Tshz1tm1Garr/Tshz1tm2.1Garr, Tg(Nes-cre)1Kln/? (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: rostral migratory stream Present Regionally restricted S8C coTSHZ1 No marked change in expression in RMS prior to entering olfactory bulb.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory