Tshz1^tm2.2Garr
Targeted Allele Detail

Summary

• Symbol: Tshz1^tm2.2Garr
• Name: teashirt zinc finger family member 1; targeted mutation 2.2, Alistair N Garratt
• MGI ID: MGI:5588817
• Synonyms: Tshz1^delta
• Gene: Tshz1 Location: Chr18:84029752-84105831 bp, - strand Genetic Position: Chr18, 57.53 cM
• Alliance: Tshz1^tm2.2Garr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209428
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP flanked exon2 of Tshz1 gene was removed. This allele was generated by crossing Tshz1^tm2.1Garr mice with mice carrying the cre-deleter allele Tg(CMV-cre)1Cgn to remove the exon2. The in situ hybridization and immunostaining on homozygous embryos confirmed absence of transcripts and functional protein products. This is a null allele. (J:209428)

Expression

In Mice Carrying this Mutation:	9 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tshz1 Mutation: 51 strains or lines available

References

• Original: J:209428 Ragancokova D, et al., TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. J Clin Invest. 2014 Mar 3;124(3):1214-27
• All: 2 reference(s)