Ntrk1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:126484 Luo W, et al., A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007 Jun 7;54(5):739-54
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7481304
Gene symbol:	Ntrk1
Gene name:	neurotrophic tyrosine kinase, receptor, type 1

Antibody:	anti-TrkA
Detection system:	Secondary antibody coupled to Alexa Fluor 488

Results

Specimen 8A: postnatal day 0; Ret^tm1Ddg/Ret^tm1Ddg (more

)

Structure	Level	Pattern	Image	Note
TS27: dorsal root ganglion	Present		8A

Specimen 8B: postnatal day 0; Ret^tm1Ddg/Ret^tm1Ddg, H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS27: dorsal root ganglion	Present		8B	Expression indistinguishable compared to control.

Specimen 8C: postnatal day 10; Ret^tm1Ddg/Ret^tm1Ddg (more

)

Structure	Level	Pattern	Image	Note
TS28: dorsal root ganglion	Present		8C

Specimen 8D: postnatal day 10; Ret^tm1Ddg/Ret^tm1Ddg, H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS28: dorsal root ganglion	Present		8D

Specimen 8E: postnatal day 14; Ret^tm1Ddg/Ret^tm1Ddg (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Weak	Regionally restricted	8E	Number of expressing neurons dramatically decreased.

Specimen 8F: postnatal day 14; Ret^tm1Ddg/Ret^tm1Ddg, H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: dorsal root ganglion	sensory neuron of dorsal root ganglion	Present		8F	Percentage of expressing neurons remained significantly more elevated compared to control.

Specimen 8I: postnatal day 14; Ret^tm1Ddg/Ret^tm1Ddg (more

)
Note: Double labeled: red - TrkA (Ntrk1); red - CGRP (Calca assay MGI:7481301).

Structure	Level	Pattern	Image	Note
TS28: dorsal root ganglion	Present	Regionally restricted	8I	Majority of TrkA-expressing cells coexpress CGRP.

Specimen 8J: postnatal day 14; Ret^tm1Ddg/Ret^tm1Ddg, H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (more

)
Note: Conditional mutant. Double labeled: red - TrkA (Ntrk1); red - CGRP (Calca assay MGI:7481301).

Structure	Level	Pattern	Image	Note
TS28: dorsal root ganglion	Present	Regionally restricted	8J	Numerous TrkA-expressing cells not coexpressing CGRP.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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