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Gene Expression Data
Assay Details
Assay
Reference: J:126484 Luo W, et al., A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007 Jun 7;54(5):739-54
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7481301
Gene symbol: Calca
Gene name: calcitonin/calcitonin-related polypeptide, alpha
Antibody: anti-CGRP
Detection system: Secondary antibody coupled to Alexa Fluor 546
Results
Specimen 3G: postnatal day 14; Rettm1Ddg/Rettm1Ddg (more )
Structure Cell Type Level Pattern Image Note
TS28: dorsal root ganglion sensory neuron of dorsal root ganglion Present 3G
Specimen 3H: postnatal day 14; Rettm1Ddg/Rettm1Ddg, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: dorsal root ganglion sensory neuron of dorsal root ganglion Present Regionally restricted 3H Number of double-labeled neurons similar to control. Soma size comparable to control.
Specimen 4A: postnatal day 14; Mrgprdtm1Mjz/Mrgprd+, Rettm1Ddg/Rettm1Ddg (more )
Note: Double labeled: red - CGRP (Calca); green - MrgD reporter (Mrgprd assay MGI:7481308).
Structure Cell Type Level Pattern Image Note
TS28: skin peptidergic neuron Present Regionally restricted 4A Expression in peptidergic fibers mostly restricted to subepidermal layer, with few free nerve ending coursing through epidermis and terminating in stratum spinosum.
Specimen 4B: postnatal day 14; Mrgprdtm1Mjz/?, Rettm1Ddg/Rettm1Ddg, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: red - CGRP (Calca); green - MrgD reporter (Mrgprd assay MGI:7481308).
Structure Cell Type Level Pattern Image Note
TS28: skin peptidergic neuron Present 4B Expression in peptidergic fibers.
Specimen 4C/G: postnatal day 14; Mrgprdtm1Mjz/Mrgprd+, Rettm1Ddg/Rettm1Ddg (more )
Note: Double labeled: red - CGRP (Calca); green - MrgD reporter (Mrgprd assay MGI:7481308).
Structure Cell Type Level Pattern Image Note
TS28: epidermis peptidergic neuron Present 4G , 4C Expression in intact fibers.
Specimen 4D/H: postnatal day 14; Mrgprdtm1Mjz/?, Rettm1Ddg/Rettm1Ddg, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: red - CGRP (Calca); green - MrgD reporter (Mrgprd assay MGI:7481308).
Structure Cell Type Level Pattern Image Note
TS28: epidermis peptidergic neuron Present Regionally restricted 4H , 4D Expression in intact fibers.
Specimen 4I: postnatal day 14; Mrgprdtm1Mjz/Mrgprd+, Rettm1Ddg/Rettm1Ddg (more )
Note: Double labeled: red - CGRP (Calca); green - MrgD reporter (Mrgprd assay MGI:7481308).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord thoracic region peptidergic neuron Present 4I Expression in peptidergic fibers.
Specimen 4I inset: postnatal day 14; Mrgprdtm1Mjz/Mrgprd+, Rettm1Ddg/Rettm1Ddg (more )
Note: Double labeled: red - CGRP (Calca); green - MrgD reporter (Mrgprd assay MGI:7481308).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord thoracic region peptidergic neuron Present 4I inset Expression in peptidergic fibers.
Specimen 4J: postnatal day 14; Mrgprdtm1Mjz/?, Rettm1Ddg/Rettm1Ddg, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: red - CGRP (Calca); green - MrgD reporter (Mrgprd assay MGI:7481308).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord thoracic region peptidergic neuron Present 4J No difference in lamina specific innervation of peptidergic projections.
Specimen 4J inset: postnatal day 14; Mrgprdtm1Mjz/?, Rettm1Ddg/Rettm1Ddg, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: red - CGRP (Calca); green - MrgD reporter (Mrgprd assay MGI:7481308).
Structure Cell Type Level Pattern Image Note
TS28: spinal cord thoracic region peptidergic neuron Present 4J inset No difference in lamina specific innervation of peptidergic projections.
Specimen 8I: postnatal day 14; Rettm1Ddg/Rettm1Ddg (more )
Note: Double labeled: red - CGRP (Calca); green - TrkA (Ntrk1 assay MGI:7481304).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present Regionally restricted 8I Expression in majority of TrkA-expressing cells.
Specimen 8J: postnatal day 14; Rettm1Ddg/Rettm1Ddg, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: red - CGRP (Calca); green - TrkA (Ntrk1 assay MGI:7481304).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present Regionally restricted 8J No expression in numerous small-diameter TrkA-expressing cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory