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Gene Expression Data
Assay Details
Assay
Reference: J:299026 Kannan-Sundhari A, et al., Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival. Front Cell Dev Biol. 2020;8:576654
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7470876
Gene symbol: Gria2
Gene name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Results
Specimen 3B Brd4+/+ P14: postnatal day 14 (more )
Note: Double labeled: green - Gria2 and Gria3; red - Ctbp2 (assay MGI:7470864).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B +/+ P14 Glur2/3 , 3B +/+ P14 Merge Expression is in postsynaptic glutamate receptors on afferent nerve terminals of inner hair cells.
Specimen 3B Atoh1-Brd4-/- P14: postnatal day 14; Brd4tm1c(EUCOMM)Wtsi/Brd4tm1c(EUCOMM)Wtsi, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Double labeled: green - Gria2 and Gria3; red - Ctbp2 (assay MGI:7470864).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B Atoh1-Brd4-/- P14 Glur2/3 , 3B Atoh1-Brd4-/- P14 Merge This mutant has reduced numbers of intact synapses compared to controls.
Specimen 3B Brd4+/+ P16: postnatal day 16 (more )
Note: Double labeled: green - Gria2 and Gria3; red - Ctbp2 (assay MGI:7470864).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B +/+ P16 Merge , 3B +/+ P16 Glur2/3 Expression is in postsynaptic glutamate receptors on afferent nerve terminals of inner hair cells.
Specimen 3B Atoh1-Brd4-/- P16: postnatal day 16; Brd4tm1c(EUCOMM)Wtsi/Brd4tm1c(EUCOMM)Wtsi, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Double labeled: green - Gria2 and Gria3; red - Ctbp2 (assay MGI:7470864).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B Atoh1-Brd4-/- P16 Merge , 3B Atoh1-Brd4-/- P16 Glur2/3 This mutant has reduced numbers of intact synapses compared to controls.
Specimen 3B Brd4+/+ P21: postnatal day 16 (more )
Note: Double labeled: green - Gria2 and Gria3; red - Ctbp2 (assay MGI:7470864).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B +/+ P21 Glur2/3 , 3B +/+ P21 Merge Expression is in postsynaptic glutamate receptors on afferent nerve terminals of inner hair cells.
Specimen 3B Atoh1-Brd4-/- P21: postnatal day 16; Brd4tm1c(EUCOMM)Wtsi/Brd4tm1c(EUCOMM)Wtsi, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Double labeled: green - Gria2 and Gria3; red - Ctbp2 (assay MGI:7470864).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3B Atoh1-Brd4-/- P21 Glur2/3 , 3B Atoh1-Brd4-/- P21 Merge This mutant has reduced numbers of intact synapses compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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