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Gene Expression Data
Assay Details
Assay
Reference: J:252121 McCoy AM, et al., IKKbeta Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis. Am J Pathol. 2017 Dec;187(12):2635-2644
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7428899
Gene symbol: Acta2
Gene name: actin alpha 2, smooth muscle, aorta
Results
Specimen 1D ctrl (upper): embryonic day 17.5; Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Double labeled: red - Acta2; green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS25: lung bronchial smooth muscle cell Present Regionally restricted 1D ctrl (upper) Expression in smooth muscle cells surrounding airways.
Specimen 1D Twist2-IKK (upper): embryonic day 17.5; Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant. Double labeled: red - Acta2; green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS25: lung bronchial smooth muscle cell Present Regionally restricted 1D Twist2-IKK (upper) Expression in smooth muscle cells surrounding airways.
Specimen 1D ctrl (lower): embryonic day 17.5; Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Double labeled: red - Acta2; green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS25: lung bronchial smooth muscle cell Present Regionally restricted 1D ctrl (lower) Expression in smooth muscle cells surrounding airways.
Specimen 1D Twist2-IKK (lower): embryonic day 17.5; Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant. Double labeled: red - Acta2; green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS25: lung bronchial smooth muscle cell Present Regionally restricted 1D Twist2-IKK (lower) Expression in smooth muscle cells surrounding airways.
Specimen 3C ctrl: embryonic day 17.5; Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Double labeled: red - Acta2; green - Pecam1 (assay MGI:7428905).
Structure Cell Type Level Pattern Image Note
TS25: lung smooth muscle cell Present 3C ctrl
TS25: lung mesenchyme Present 3C ctrl
Specimen 3C Twist2-IKK: embryonic day 17.5; Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant. Double labeled: red - Acta2; green - Pecam1 (assay MGI:7428905).
Structure Cell Type Level Pattern Image Note
TS25: lung smooth muscle cell Present 3C Twist2-IKK
TS25: lung mesenchyme Present 3C Twist2-IKK
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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