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Gene Expression Data
Assay Details
Assay
Reference: J:309724 Rux D, et al., Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice. Dev Biol. 2021 Sep;477:49-63
Assay type: RNA in situ
MGI Accession ID: MGI:7378534
Gene symbol: Hoxa11
Gene name: homeobox A11
Probe: Mm-Hoxa11 (495561)
Probe preparation: Antisense
Visualized with: Chromogenic
Results
Specimen 1S: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: scapholunate Present Regionally restricted 1S Expression was restricted to the outer cells of the scaphoid and lunate in the wrist.

Specimen 1T: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: elbow Absent 1T

Specimen 1U: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: calcaneus Present Regionally restricted 1U Expression was restricted to the outer cells of the calcaneous and talus in the ankle.
TS23: talus Present Regionally restricted 1U Expression was restricted to the outer cells of the calcaneous and talus in the ankle.

Specimen 1V: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: knee Present 1V

Specimen 2E: embryonic day 15.5 (more )
Note: medial region.
Structure Level Pattern Image Note
TS23: knee Present Regionally restricted 2E Expression was detected in the medial component of the knee.
TS23: long bone epiphyseal plate Present Regionally restricted 2E Expression was detected in the medial region.

Specimen 2F: embryonic day 15.5 (more )
Note: center region.
Structure Level Pattern Image Note
TS23: knee Present Regionally restricted 2F Expression was detected in the center component of the knee.
TS23: long bone epiphyseal plate Present Regionally restricted 2F Expression was detected in the medial region.

Specimen 2G: embryonic day 15.5 (more )
Note: lateral region.
Structure Level Pattern Image Note
TS23: knee Weak Regionally restricted 2G Miminal expression was detected in the lateral component of the knee.
TS23: long bone epiphyseal plate Weak Regionally restricted 2G Miminal expression was detected in the lateral region.

Specimen 2H: embryonic day 15.5 (more )
Note: patella region.
Structure Level Pattern Image Note
TS23: knee Weak Regionally restricted 2H Miminal expression was detected in the patella component.
TS23: patella pre-cartilage condensation Weak Regionally restricted 2H

Specimen 3G: postnatal newborn (more )
Structure Cell Type Level Pattern Image Note
TS27: articular cartilage articular chondrocyte Strong Regionally restricted 3G There was strong expression in the nascent articular chondrocytes juxtaposed to the emerging synovial joint space.
TS27: long bone epiphyseal plate ossification zone chondrocyte Present Regionally restricted 3G Expression was detected in secondary ossification center/epiphyseal cartilage of the radius.
TS27: radius chondrocyte Present Regionally restricted 3G Expression was detected in secondary ossification center/epiphyseal cartilage of the radius.

Specimen 3H: postnatal newborn (more )
Structure Cell Type Level Pattern Image Note
TS27: articular cartilage articular chondrocyte Strong Regionally restricted 3H There was strong expression in the nascent articular chondrocytes juxtaposed to the emerging synovial joint space.
TS27: long bone epiphyseal plate ossification zone chondrocyte Present Regionally restricted 3H Expression was detected in secondary ossification center/epiphyseal cartilage of the tibia.
TS27: tibia chondrocyte Present Regionally restricted 3H Expression was detected in secondary ossification center/epiphyseal cartilage of the tibia.

Specimen 4E: postnatal newborn (more )
Note: medial region.
Structure Level Pattern Image Note
TS27: tibia Present Regionally restricted 4F , 4E Expression was largely confined to the medial portion of the tibial plateau.

Specimen 4G: postnatal newborn (more )
Note: center region.
Structure Level Pattern Image Note
TS27: knee joint Present Regionally restricted 4G , 4H Expression was prominent in centrally-located intra joint ligaments.
TS27: ligament Present Regionally restricted 4G , 4H Expression was prominent in centrally-located intra joint ligaments.

Specimen 4I: postnatal newborn (more )
Note: lateral region.
Structure Level Pattern Image Note
TS27: tibia Weak Regionally restricted 4I , 4J Expression was minimal in lateral portions of the tibial plateau.

Specimen 4K: postnatal newborn (more )
Note: patella region.
Structure Level Pattern Image Note
TS27: patella Weak 4L , 4K

Specimen S2A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: wrist Strong S2A
TS23: shoulder Absent S2A , S2C

Specimen S2B: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: ankle Strong S2B
TS23: knee Strong S2B
TS23: sacral vertebral cartilage condensation Strong S2B , S2E
TS23: hip Absent S2B , S2D


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory