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Gene Expression Data
Assay Details
Assay
Reference: J:327815 Beauchamp MC, et al., Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion. Int J Mol Sci. 2022 Aug 12;23(16)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7341544
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Antibody: anti-Sox10 (7833)
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 3A: embryonic day 9.0; Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53+ (more )
Structure Level Pattern Image Note
TS14: branchial arch Present Regionally restricted 3A merge (lower) , 3A merge (upper) , 3A SOX10 (lower) , 3A SOX10 (upper) Expression in post-migratory neural crest cells in and around the eye and in pharyngeal arches.
TS14: eye Present Regionally restricted 3A merge (lower) , 3A merge (upper) , 3A SOX10 (lower) , 3A SOX10 (upper) Expression in post-migratory neural crest cells in and around the eye and in pharyngeal arches.
Specimen 3B: embryonic day 9.0; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS14: 1st branchial arch Weak 3B SOX10 (lower) , 3B SOX10 (upper) , 3B merge (lower) , 3B merge (upper) Reduced expression in frontonasal mass and first pharyngeal arch compared to controls.
TS14: fronto-nasal process Weak 3B SOX10 (lower) , 3B SOX10 (upper) , 3B merge (lower) , 3B merge (upper) Reduced expression in frontonasal mass and first pharyngeal arch compared to controls.
Specimen 3C: embryonic day 9.0; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS14: branchial arch Present Regionally restricted 3.C merge (upper) , 3.C merge (lower) , 3.C SOX10 (lower) , 3.C SOX10 (upper) Expression comparable to that of controls, and higher than in Eftud2ncc-/- embryos.
TS14: eye Present Regionally restricted 3.C merge (upper) , 3.C merge (lower) , 3.C SOX10 (lower) , 3.C SOX10 (upper) Expression comparable to that of controls, and higher than in Eftud2ncc-/- embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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