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Gene Expression Data
Assay Details
Assay
Reference: J:187296 Kaul D, et al., Expression of Toll-like receptors in the developing brain. PLoS One. 2012;7(5):e37767
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7334844
Gene symbol: Tlr7
Gene name: toll-like receptor 7
Antibody: anti-TLR7
Detection system: Secondary antibody
Results
Specimen 4A E16: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: neocortex Present 4A E16
Specimen 4A P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: neocortex Present 4A P0 Expression reached a peak at early postnatal stages.
Specimen 4A P12: postnatal day 12 (more )
Structure Level Pattern Image Note
TS28: neocortex Present 4A P12 Expression reached a peak at early postnatal stages.
Specimen 4A P5m: postnatal month 5 (more )
Structure Level Pattern Image Note
TS28: neocortex Present 4A P5m
Specimen 4B: postnatal day 12 (more )
Note: Double labeled: green - Tlr7; red - Rbfox3 (assay MGI:7334845).
Structure Cell Type Level Pattern Image Note
TS28: cortical layer II cerebral cortex neuron Strong 4B TLR7 , 4B merged
TS28: cortical layer III cerebral cortex neuron Strong 4B TLR7 , 4B merged
TS28: neocortex cerebral cortex neuron Present 4B merged , 4B TLR7
Specimen 4D WT: postnatal day 12 (more )
Structure Level Pattern Image Note
TS28: brain Present 4D WT
Specimen 4D TLR7-/-: postnatal day 12; Tlr7tm1Aki/Tlr7tm1Aki (more )
Structure Level Pattern Image Note
TS28: brain Absent 4D -/-
Specimen 5A CPu: postnatal day 12 (more )
Structure Cell Type Level Pattern Image Note
TS28: caudate-putamen neuron Present Regionally restricted 5A P12 CPu Expression is in axons, partially bundled as tracts.
Specimen 5A ff: postnatal day 12 (more )
Structure Cell Type Level Pattern Image Note
TS28: fimbria hippocampus neuron Present Regionally restricted 5A ff P12 Expression is in axons, partially bundled as tracts.
Specimen 5A LSD: postnatal day 12 (more )
Structure Cell Type Level Pattern Image Note
TS28: telencephalon septum neuron Present Regionally restricted 5A LSD P12 Expression is in axons, partially bundled as tracts. in the dorso-lateral septum.
Specimen 5A cc: postnatal day 12 (more )
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum neuron Present Regionally restricted 5A P12 *** , 5A cc P12 , 5A P12 * Expression is in axons, partially bundled as tracts.
Specimen 5A Pm5 CPu: postnatal month 5 (more )
Structure Cell Type Level Pattern Image Note
TS28: caudate-putamen neuron Weak 5A P5m CPu , 5A P5m ** , 5A P5m **** There are no or low levels of positive axons.
Specimen 5A Pm5 ff: postnatal month 5 (more )
Structure Cell Type Level Pattern Image Note
TS28: fimbria hippocampus neuron Weak 5A ff P5m There are no or low levels of positive axons.
Specimen 5A Pm5 LSD: postnatal month 5 (more )
Structure Cell Type Level Pattern Image Note
TS28: telencephalon septum neuron Weak Regionally restricted 5A LSD P5m There are no or low levels of positive axons in the dorso-lateral septum.
Specimen 5A Pm5 cc: postnatal month 5 (more )
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum neuron Weak 5A cc P5m There are no or low levels of positive axons.
Specimen 5B: postnatal day 12 (more )
Note: Double labeled: green - Tlr7; red - Nefm (assay MGI:7334851).
Structure Cell Type Level Pattern Image Note
TS28: corpus striatum neuron Present Regionally restricted 5B TLR7 , 5B * , 5B merged Positive axons did not co-localize with the neurofilament antibody, but were instead nestling between neurofilament-positive axons. A few punctiform structures were positive for both.
Specimen 5C top: postnatal day 12 (more )
Note: Double labeled: green - Tlr7; red - Aif1 (assay MGI:7334853).
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum microglial cell Present 5C merged top , 5C TLR7 top
TS28: corpus callosum astrocyte Absent 5C merged top , 5C TLR7 top
Specimen 5C middle: postnatal day 12 (more )
Note: Double labeled: green - Tlr7; red - oligodendrocytes.
Structure Level Pattern Image Note
TS28: corpus callosum Present 5C TLR7 middle , 5C merged middle
Specimen 5C bottom: postnatal day 12 (more )
Note: Double labeled: green - Tlr7; red - Gfap (assay MGI:7334855).
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum microglial cell Present 5C TRL7 bottom , 5C merged bottom
TS28: corpus callosum astrocyte Absent 5C merged bottom , 5C TRL7 bottom
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory