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Gene Expression Data
Assay Details
Assay
Reference: J:136642 Matera I, et al., A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum Mol Genet. 2008 Jul 15;17(14):2118-31
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7286041
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Reporter: lacZ
Direct Detection
Assay notes: Fixation was with 1% formaldehyde; 0.2% glutaraldehyde.
Results
Specimen 5A: embryonic day 11.5; Sox10tm1Weg/Sox10+ (more )
Structure Level Pattern Image Note
TS19: cranial ganglion Present 5A
TS19: dorsal root ganglion Present 5A
TS19: sympathetic ganglion Present 5A
Specimen 5B: embryonic day 11.5; Gli3Mos1/Gli3Mos1, Sox10tm1Weg/Sox10+ (more )
Structure Level Pattern Image Note
TS19: cranial ganglion Present 5B Expression in unaffected compared to control embryos.
TS19: dorsal root ganglion Present 5B Expression in unaffected compared to control embryos.
TS19: sympathetic ganglion Present 5B Expression in unaffected compared to control embryos.
Specimen 5C: embryonic day 11.5; Gli3Xt-J/Gli3Xt-J, Sox10tm1Weg/Sox10+ (more )
Structure Level Pattern Image Note
TS19: cranial ganglion Present 5C Expression in unaffected compared to control embryos.
TS19: dorsal root ganglion Present 5C Expression in unaffected compared to control embryos.
TS19: sympathetic ganglion Present 5C Expression in unaffected compared to control embryos.
Specimen 5D: embryonic day 11.5; Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Present 5D
Specimen 5E: embryonic day 11.5; Gli3Mos1/Gli3Mos1, Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Weak Regionally restricted 5E Reduced number of expressing melanoblasts in medial lateral trunk region compared to control embryos.
TS19: trunk Present Single cells 5E Ectopic expression in larger cells adjacent to neural tube dorsal to dorsal root ganglia.
Specimen 5F: embryonic day 11.5; Gli3Xt-J/Gli3Xt-J, Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Weak Regionally restricted 5F Reduced number of expressing melanoblasts in medial lateral trunk region compared to control embryos.
TS19: trunk Present Single cells 5F Ectopic expression in larger cells adjacent to neural tube dorsal to dorsal root ganglia.
Specimen 5G: embryonic day 11.5; Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Present 5G
Specimen 5H: embryonic day 11.5; Gli3Mos1/Gli3Mos1, Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Weak Regionally restricted 5H Reduced number of expressing melanoblasts in medial lateral trunk region compared to control embryos.
TS19: trunk Present Single cells 5H Ectopic expression in larger cells adjacent to neural tube dorsal to dorsal root ganglia.
Specimen 5I: embryonic day 11.5; Gli3Xt-J/Gli3Xt-J, Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Weak Regionally restricted 5I Reduced number of expressing melanoblasts in medial lateral trunk region compared to control embryos.
TS19: trunk Present Single cells 5I Ectopic expression in larger cells adjacent to neural tube dorsal to dorsal root ganglia.
Specimen 5J: embryonic day 11.5; Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Present 5J
Specimen 5K: embryonic day 11.5; Gli3Mos1/Gli3Mos1, Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Weak Regionally restricted 5K Reduced number of expressing melanoblasts in medial lateral trunk region compared to control embryos.
Specimen 5L: embryonic day 11.5; Gli3Xt-J/Gli3Xt-J, Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Weak Regionally restricted 5L Reduced number of expressing melanoblasts in medial lateral trunk region compared to control embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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