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Gene Expression Data
Assay Details
Assay
Reference: J:308695 Talley MJ, et al., Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Front Cell Dev Biol. 2021;9:673995
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7281563
Gene symbol: Gfap
Gene name: glial fibrillary acidic protein
Results
Specimen 4A: postnatal month 1; Lztr1tm1c(EUCOMM)Wtsi/Lztr1+ (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex astrocyte of the cerebral cortex Present Regionally restricted 4A Expression was detected in isolated cells of the cortex.
Specimen 4B: postnatal month 1; Lztr1tm1b(EUCOMM)Wtsi/Lztr1tm1c(EUCOMM)Wtsi, Foxg1tm1.1(cre)Ddmo/Foxg1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex astrocyte of the cerebral cortex Present Regionally restricted 4B The conditional mutant had a 57.8% increase in total pixel intensity in the lateral cortex compared with control.
Specimen 4C: postnatal month 1; Lztr1tm1c(EUCOMM)Wtsi/Lztr1+ (more )
Structure Cell Type Level Pattern Image Note
TS28: hippocampus hippocampal astrocyte Present Regionally restricted 4C Expression was robust in the hippocampus astrocytes in the CA region.
Specimen 4D: postnatal month 1; Lztr1tm1b(EUCOMM)Wtsi/Lztr1tm1c(EUCOMM)Wtsi, Foxg1tm1.1(cre)Ddmo/Foxg1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: hippocampus hippocampal astrocyte Present Regionally restricted 4D Expression increased 33.5% in the CA region of the hippocampus of the conditional mutant compared to control.
Specimen 4E: postnatal month 1; Lztr1tm1c(EUCOMM)Wtsi/Lztr1+ (more )
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum astrocyte Present 4E
Specimen 4F: postnatal month 1; Lztr1tm1b(EUCOMM)Wtsi/Lztr1tm1c(EUCOMM)Wtsi, Foxg1tm1.1(cre)Ddmo/Foxg1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum astrocyte Present 4F Gfap labeled cells appeared to have more defined cell bodies, but the staining intensity was not significantly different in the conditional mutant corpus callosum compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory