About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:307598 Pihlajoki M, et al., GATA6 modulates the ductular reaction to bile duct ligation. Hepatol Int. 2021 Feb;15(1):166-178
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6726299
Gene symbol: Gata6
Gene name: GATA binding protein 6
Antibody: anti-Gata6 (AF1700)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen S1A: postnatal month 2; Gata6tm2.1Sad/Gata6tm2.1Sad (more )
Structure Level Pattern Image Note
TS28: intrahepatic bile duct epithelium Present Regionally restricted S1A Nuclear expression in cholangiocytes within small and large intrahepatic bile ducts of adult mice.
TS28: liver parenchyma Absent S1A No expression in hepatocytes.
Specimen S3A: postnatal day 1; Gata6tm2.1Sad/Gata6tm2.1Sad (more )
Structure Level Pattern Image Note
TS27: intrahepatic bile duct epithelium Present Regionally restricted S3A Nuclear expression in cholangiocytes of small bile ducts in neonatal mice.
TS27: liver sinusoid Present Regionally restricted S3A Variable expression in Kupffer cells. Variable expression in sinusoidal/venous endothelial cells.
TS27: liver vasculature Present Regionally restricted S3A Variable expression in Kupffer cells. Variable expression in sinusoidal/venous endothelial cells.
Specimen S3B: postnatal day 1; Gata6tm2.1Sad/Gata6tm2.1Sad (more )
Structure Level Pattern Image Note
TS27: intrahepatic bile duct epithelium Present Regionally restricted S3B Nuclear expression in cholangiocytes of large bile ducts in neonatal mice.
TS27: liver sinusoid Present Regionally restricted S3B Variable expression in sinusoidal/venous endothelial cells.
TS27: liver vasculature Present Regionally restricted S3B Variable expression in sinusoidal/venous endothelial cells.
Specimen S6A: postnatal month 2; Gata6tm2.1Sad/Gata6tm2.1Sad, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: interlobular bile duct Present Regionally restricted S6A Expression in vast majority (>90%) of cholangiocytes lining large interlobar bile ducts in liver hilum.
Specimen S6B: postnatal month 2; Gata6tm2.1Sad/Gata6tm2.1Sad, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: intrahepatic bile duct epithelium Present Regionally restricted S6B Expression in vast majority (>90%) of cholangiocytes lining smaller bile ducts in periphery of liver.
Specimen 1c: embryonic day 15.5; Gata6tm2.1Sad/Gata6tm2.1Sad (more )
Structure Level Pattern Image Note
TS23: biliary tract Absent 1c No expression in Sox9-expressing ductal plate cells.
Specimen 1c inset: embryonic day 15.5; Gata6tm2.1Sad/Gata6tm2.1Sad (more )
Structure Level Pattern Image Note
TS23: heart atrium Present 1c inset
Specimen 1d: embryonic day 15.5; Gata6tm2.1Sad/Gata6tm2.1Sad, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: biliary tract Absent 1d No expression in Sox9-expressing ductal plate cells
Specimen 1d inset: embryonic day 15.5; Gata6tm2.1Sad/Gata6tm2.1Sad, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: heart atrium Present 1d inset
Specimen 1e: postnatal day 1; Gata6tm2.1Sad/Gata6tm2.1Sad (more )
Structure Level Pattern Image Note
TS27: intrahepatic bile duct epithelium Present Regionally restricted 1e Expression in cholangiocytes indicating upregulation in biliary epithelial cells between E15.5 and P2, coinciding with bile duct formation/maturation.
Specimen 1f: postnatal day 1; Gata6tm2.1Sad/Gata6tm2.1Sad, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: intrahepatic bile duct epithelium Present Regionally restricted 1f Expression in cholangiocytes.
Specimen S7B: postnatal day 30; Gata6tm2.1Sad/Gata6tm2.1Sad (more )
Structure Level Pattern Image Note
TS28: intrahepatic bile duct epithelium Present Regionally restricted S7B Expression in cholangiocytes within bile ducts.
TS28: liver vasculature Present Regionally restricted S7B Expression in endothelial cells.
Specimen S9: postnatal adult; Gata6tm2.1Sad/Gata6tm2.1Sad, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: intrahepatic bile duct epithelium Present Regionally restricted S9 Expression in cholangiocytes. Authors report area of mild ductal reaction.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory