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Gene Expression Data
Assay Details
Assay
Reference: J:207611 Lange AW, et al., Sox17 is required for normal pulmonary vascular morphogenesis. Dev Biol. 2014 Mar 1;387(1):109-20
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6717406
Gene symbol: Sox17
Gene name: SRY (sex determining region Y)-box 17
Antibody: anti-Sox17
Results
Specimen 2C: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lung vascular element Present Regionally restricted 2C Expression was more strongly detected in arterial and microvascular endothelial cells compared to veins.
TS26: pulmonary artery Present Regionally restricted 2C Expression was more strongly detected in arterial and microvascular endothelial cells compared to veins.
TS26: pulmonary vein Present Regionally restricted 2C Expression was more strongly detected in arterial and microvascular endothelial cells compared to veins.
Specimen 2D: embryonic day 18.5; Sox17tm1Jaw/Sox17tm1Jaw, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: lung vascular element Weak Regionally restricted 2D Extensive, but variable loss of expression in arterial, venous, and microvascular endothelial cells.
TS26: pulmonary artery Weak Regionally restricted 2D Extensive, but variable loss of expression in arterial, venous, and microvascular endothelial cells.
TS26: pulmonary vein Weak Regionally restricted 2D Extensive, but variable loss of expression in arterial, venous, and microvascular endothelial cells.
Specimen 2E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: pulmonary vein Present Regionally restricted 2E Expressed in endothelial cells lining the lumen.
Specimen 2F: embryonic day 18.5; Sox17tm1Jaw/Sox17tm1Jaw, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: pulmonary artery Present Regionally restricted 2F Expressed in endothelial cells lining the lumen.
Specimen 2G: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: pulmonary vein Weak Regionally restricted 2G Extensive, but variable loss of expression in endothelial cells.
Specimen 2H: embryonic day 18.5; Sox17tm1Jaw/Sox17tm1Jaw, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: pulmonary artery Weak Regionally restricted 2H Extensive, but variable loss of expression in endothelial cells.
Specimen S3A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: coronary vascular plexus Present Regionally restricted S3A Expressed in endothelial cells.
TS26: heart endothelium Present Regionally restricted S3A Expressed in intramyocardial endothelial cells.
TS26: endocardial lining Present Regionally restricted S3A Expressed in rare endocardial cells lining the valve leaflets.
TS26: heart valve Present Regionally restricted S3A Expressed in rare endocardial cells lining the valve leaflets.
Specimen S3B: embryonic day 18.5; Sox17tm1Jaw/Sox17tm1Jaw, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: heart Present S3B Similar as in the control.
Specimen not shown: postnatal (more )
Structure Level Pattern Image Note
TS28: coronary vascular plexus Present Regionally restricted Expressed in endothelial cells.
TS28: heart endothelium Present Regionally restricted Expressed in intramyocardial endothelial cells.
TS28: endocardial lining Present Regionally restricted Expressed in rare endocardial cells lining the valve leaflets.
TS28: heart valve Present Regionally restricted Expressed in rare endocardial cells lining the valve leaflets.
Specimen not shown: postnatal; Sox17tm1Jaw/Sox17tm1Jaw, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: heart Present Similar as in the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory