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Gene Expression Data
Assay Details
Assay
Reference: J:154915 Morrison KM, et al., Mammalian Merkel cells are descended from the epidermal lineage. Dev Biol. 2009 Dec 1;336(1):76-83
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6716266
Gene symbol: Krt8
Gene name: keratin 8
Antibody: TROMA 1
Results
Specimen E14.5 LacZ/+ not shown: embryonic day 14.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS22: vibrissa follicle Present Expression first detected in whisker follicles at E14.5.
Specimen 2A'' (upper): embryonic day 15.5; Atoh1tm2Hzo/Atoh1+ (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS23: vibrissa follicle Strong Regionally restricted 2A'' (upper) , 2A''' (upper) Large expansion of expressing cells.
Specimen 2A'' (lower left): embryonic day 15.5; Atoh1tm2Hzo/Atoh1+ (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS23: vibrissa follicle Strong Regionally restricted 2A''' (lower left) , 2A'' (lower left) Large expansion of expressing cells.
Specimen 2A'' (lower right): embryonic day 15.5; Atoh1tm2Hzo/Atoh1+ (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS23: vibrissa follicle Strong Regionally restricted 2A'' (lower right) , 2A''' (lower right) Large expansion of expressing cells.
Specimen 2B'' (upper): embryonic day 15.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS23: vibrissa follicle Absent 2B''' (upper) , 2B'' (upper) No expression in LacZ/LacZ embryos.
Specimen 2B'' (lower): embryonic day 15.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS23: vibrissa follicle Absent 2B'' (lower) , 2B''' (lower) No expression in LacZ/LacZ embryos.
Specimen E16.5 LacZ/+ not shown: embryonic day 16.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS24: trunk skin Present Regionally restricted Expression in touch domes first detected at E16.5.
Specimen 3D'' (upper): postnatal day 0; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS27: vibrissa follicle Present 3D''' (upper) , 3D'' (upper) Expression in Atoh1-expressing cells in vibrissa follicle.
Specimen 3D'' (lower): postnatal day 0; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS27: vibrissa follicle Present 3D''' (lower) , 3D'' (lower) Expression in Atoh1-expressing cells in vibrissa follicle.
Specimen 3F'' (upper): postnatal day 0; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS27: skin Present Regionally restricted 3F'' (upper) , 3F''' (upper) Expression in Atoh1-expressing cells in touch domes.
Specimen 3F'' (lower): postnatal day 0; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS27: skin Present Regionally restricted 3F'' (lower) , 3F''' (lower) Expression in Atoh1-expressing cells in touch domes.
Specimen S2C'' (upper): postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Cre reporter; blue - DAPI.
Structure Level Pattern Image Note
TS28: skin Present Regionally restricted S2C'' (upper) , S2C''' (upper) Expression in touch domes. No co-expression with Wnt1-reporter.
Specimen S2C'' (lower): postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Cre reporter; blue - DAPI.
Structure Level Pattern Image Note
TS28: skin Present Regionally restricted S2C'' (lower) , S2C''' (lower) Expression in touch domes. No co-expression with Wnt1-reporter.
Specimen S2E'' (upper): postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Cre reporter; blue - DAPI.
Structure Level Pattern Image Note
TS28: vibrissa follicle Present Regionally restricted S2E''' (upper) , S2E'' (upper) Expression in Merkel cells. No co-expression with Wnt1-reporter.
Specimen S2E'' (lower left): postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Cre reporter; blue - DAPI.
Structure Level Pattern Image Note
TS28: vibrissa follicle Present Regionally restricted S2E''' (lower left) , S2E'' (lower left) Expression in Merkel cells. No co-expression with Wnt1-reporter
Specimen S2E'' (lower right): postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Cre reporter; blue - DAPI.
Structure Level Pattern Image Note
TS28: vibrissa follicle Present Regionally restricted S2E''' (lower right) , S2E'' (lower right) Expression in Merkel cells. No co-expression with Wnt1-reporter
Specimen S2G'' (upper): postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Cre reporter; blue - DAPI.
Structure Level Pattern Image Note
TS28: metapodial pad Present Regionally restricted S2G''' (upper) , S2G'' (upper) Expression in rete ridge. No co-expression with Wnt1-reporter.
Specimen S2G'' (lower): postnatal adult; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Cre reporter; blue - DAPI.
Structure Level Pattern Image Note
TS28: metapodial pad Present Regionally restricted S2G''' (lower) , S2G'' (lower) Expression in rete ridge. No co-expression with Wnt1-reporter.
Specimen 4C'' (upper): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: skin Present Regionally restricted 4C''' (upper) , 4C'' (upper) Expression in touch dome of body skin.
Specimen 4C'' (lower): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: skin Present Regionally restricted 4C''' (lower) , 4C'' (lower) Expression in touch dome of body skin.
Specimen 4F'' (upper): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: skin Absent 4F'' (upper) , 4F''' (upper) Expression absent from all skin areas.
Specimen 4F'' (lower): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: skin Absent 4F''' (lower) , 4F'' (lower) Expression absent from all skin areas.
Specimen 4I'' (upper): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: vibrissa follicle Present 4I'' (upper) , 4I''' (upper)
Specimen 4I'' (lower): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: vibrissa follicle Present 4I'' (lower) , 4I''' (lower)
Specimen 4L'' (upper): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: vibrissa follicle Absent 4L'' (upper) , 4L''' (upper) Expression absent from all skin areas.
Specimen 4L'' (lower): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: vibrissa follicle Absent 4L''' (lower) , 4L'' (lower) Expression absent from all skin areas.
Specimen 4O'' (upper): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: metapodial pad Present Regionally restricted 4O'' (upper) , 4O''' (upper) Expression in foot rete ridges.
Specimen 4O'' (lower): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Note: Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: metapodial pad Present Regionally restricted 4O'' (lower) , 4O''' (lower) Expression in foot rete ridges.
Specimen 4R'' (upper): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: metapodial pad Absent 4R'' (upper) , 4R''' (upper) Expression absent from all skin areas.
Specimen 4R'' (lower): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Krt8; green - Atoh1 reporter (assay MGI:6716264); blue - DAPI.
Structure Level Pattern Image Note
TS28: metapodial pad Absent 4R''' (lower) , 4R'' (lower) Expression absent from all skin areas.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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