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Gene Expression Data
Assay Details
Assay
Reference: J:247897 Cetera M, et al., Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns. Dev Biol. 2017 Aug 01;428(1):188-203
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6715649
Gene symbol: Celsr1
Gene name: cadherin, EGF LAG seven-pass G-type receptor 1
Antibody: anti-Celsr1
Results
Specimen 5A control: postnatal day 4; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Vangl2tm1.1Mdea/Vangl2+ (more )
Note: The genetic background of this specimen was either heterozygous or homozygous for the Vangl2 flowed allele.
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 5A control Expression asymetrically distributed towards anterior and posterior sides of of interfollicular basal cells, correlating with axis of hair follicle allignment.
Specimen 5A Vangl2 cKO: postnatal day 4; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Tg(KRT14-cre)1Efu/0, Vangl2tm1.1Mdea/Vangl2tm1.1Mdea (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 5A Vangl2 cKO Asymmetry of expression strongly reduced or randomized, and largely uncorrelated with follicle orientation.
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 5A Fz6 KO Asymmetry of expression strongly reduced or randomized, and largely uncorrelated with follicle orientation.
Specimen 5B control: postnatal day 4; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Vangl2tm1.1Mdea/Vangl2+ (more )
Note: The genetic background of control specimen was either heterozygous or homozygous for the Vangl2 floxed allele.
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 5B control Expression asymetrically distributed towards anterior and posterior sides of of interfollicular basal cells, correlating with axis of hair follicle allignment.
Specimen 5B Vangl2 cKO: postnatal day 4; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Tg(KRT14-cre)1Efu/0, Vangl2tm1.1Mdea/Vangl2tm1.1Mdea (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 5B Vangl2 cKO Expression in epidermis surrounding hair follicle is highly disordered and does not align with follicles.
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 5B Fz6 KO Asymmetry of expression strongly reduced or randomized, and largely uncorrelated with follicle orientation.
Specimen 5C control: postnatal day 4; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Vangl2tm1.1Mdea/Vangl2+ (more )
Note: The genetic background of control specimen was either heterozygous or homozygous for the Vangl2 floxed allele.
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 5C control Expression asymetrically distributed towards anterior and posterior sides of of interfollicular basal cells, correlating with axis of hair follicle allignment.
Specimen 5C Vangl2 cKO: postnatal day 4; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Tg(KRT14-cre)1Efu/0, Vangl2tm1.1Mdea/Vangl2tm1.1Mdea (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 5C Vangl2 cKO Asymmetry of expression strongly reduced or randomized, and largely uncorrelated with follicle orientation.
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 5C Fz6 KO Asymmetry of expression strongly reduced or randomized, and largely uncorrelated with follicle orientation.
Specimen 6C control (left): embryonic day 17.5; Tg(KRT14-cre)1Efu/0, Vangl2tm1.1Mdea/Vangl2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: epidermis Present Regionally restricted 6C control (left) Angular distribution of polarity of expression closely correlated with orientaion of hair follicles.
Specimen 6C Vangl2 cKO: embryonic day 17.5; Tg(KRT14-cre)1Efu/0, Vangl2tm1.1Mdea/Vangl2tm1.1Mdea (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: epidermis Present Regionally restricted 6C Vangl2 cKO Asymmetry of expression is highly reduced.
Specimen 6C control (right): embryonic day 17.5; Fzd6tm1Nat/Fzd6+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS25: epidermis Present Regionally restricted 6C control (right) Angular distribution of polarity of expression closely correlated with orientaion of hair follicles.
Specimen 6C Fz6 KO: embryonic day 17.5; Fzd6tm1Nat/Fzd6tm1Nat, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS25: epidermis Present Regionally restricted 6C Fz6 KO Asymmetry of expression is highly reduced.
Specimen 7D control (left): embryonic day 15.5; Tg(KRT14-cre)1Efu/0, Vangl2tm1.1Mdea/Vangl2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: epidermis Present Regionally restricted 7D control (left) Anterior-posterior enrichment of expression in control embryos.
Specimen 7D Vangl2 cKO: embryonic day 15.5; Tg(KRT14-cre)1Efu/0, Vangl2tm1.1Mdea/Vangl2tm1.1Mdea (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: epidermis Present Regionally restricted 7D Vangl2 cKO Polarity of expression asymmetry in interfollicular epidermis strongly reduced; more uniformly distributed around cell cortex.
Specimen 7D control (right): embryonic day 15.5; Fzd6tm1Nat/Fzd6+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS23: epidermis Present Regionally restricted 7D control (right) Anterior-posterior enrichment of expression in control embryos.
Specimen 7D Fz6 KO: embryonic day 15.5; Fzd6tm1Nat/Fzd6tm1Nat, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS23: epidermis Present Regionally restricted 7D Fz6 KO Polarity of expression asymmetry in interfollicular epidermis strongly reduced; more uniformly distributed around cell cortex.
Specimen 8C control: embryonic day 15.5; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Vangl1tm1.1Nat/Vangl1tm1.1Nat, Vangl2tm1.1Mdea/Vangl2+ (more )
Note: The genetic background of control specimen was either heterozygous or homozygous for the Vangl2 floxed allele.
Structure Level Pattern Image Note
TS23: epidermis Present Regionally restricted 8C control Asymmetrical expression in interfollicular epidermis.
Specimen 8C Vangl1:Vangl2 dcKO: embryonic day 15.5; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Tg(KRT14-cre)1Efu/0, Vangl1tm1.1Nat/Vangl1tm1.1Nat, Vangl2tm1.1Mdea/Vangl2tm1.1Mdea (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: epidermis Present Regionally restricted 8C Vangl1:Vangl2 dcKO Loss of expression asymmetry in interfollicular epidermis.
Specimen 8E control: postnatal day 7; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Vangl1tm1.1Nat/Vangl1tm1.1Nat, Vangl2tm1.1Mdea/Vangl2+ (more )
Note: The genetic background of control specimen was either heterozygous or homozygous for the Vangl2 floxed allele.
Structure Level Pattern Image Note
TS28: back skin Present Regionally restricted 8E control Asymmetrical expression in interfollicular epidermis.
Specimen 8E Vangl1;Vangl2 dcKO: postnatal day 7; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Tg(KRT14-cre)1Efu/0, Vangl1tm1.1Nat/Vangl1tm1.1Nat, Vangl2tm1.1Mdea/Vangl2tm1.1Mdea (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: back skin Present Regionally restricted 8E Vangl2:Vangl2 dcKO Loss of expression asymmetry in interfollicular epidermis.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
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