Vangl2^tm1.1Mdea
Targeted Allele Detail

Summary

• Symbol: Vangl2^tm1.1Mdea
• Name: VANGL planar cell polarity 2; targeted mutation 1.1, Michael R Deans
• MGI ID: MGI:5430220
• Synonyms: vangl2^LoxP
• Gene: Vangl2 Location: Chr1:171828527-171856011 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Vangl2^tm1.1Mdea page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185311
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:185311)

Expression

In Mice Carrying this Mutation:

19 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vangl2 Mutation: 34 strains or lines available

Notes

This line no longer exists.

References

• Original: J:185311 Yin H, et al., Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One. 2012;7(2):e31988
• All: 4 reference(s)