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Gene Expression Data
Assay Details
Assay
Reference: J:103603 Pan Y, et al., Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol. 2005 Oct 15;286(2):472-82
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6715205
Gene symbol: Notch1
Gene name: notch 1
Results
Specimen 3A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: neural tube Strong Regionally restricted 3A (left) , 3A (right) Strong expression in ventral neural tube.
TS19: hindlimb bud ectoderm Present Regionally restricted 3A (left) , 3A (right) Expression in non-AER ectoderm.
TS19: hindlimb bud mesenchyme Weak Single cells 3A (right) , 3A (left) Sporadic expression in fraction of mesenchymal cells.
Specimen 3A (middle): embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 3A (middle)
Specimen 3B: embryonic day 11.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Haa/Psen2tm1Haa, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: neural tube Strong Regionally restricted 3B (right) , 3B (left) Strong expression in ventral neural tube.
TS19: hindlimb bud ectoderm Absent 3B (right) , 3B (left)
TS19: hindlimb bud mesenchyme Weak Single cells 3B (left) , 3B (right) Sporadic expression in fraction of mesenchymal cells.
Specimen 3B (middle): embryonic day 11.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Haa/Psen2tm1Haa, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Absent 3B (middle)
Specimen 3C: embryonic day 11.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm1Rko/Notch2tm1Rko, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: hindlimb bud ectoderm Absent 3C (left) , 3C (right)
TS19: hindlimb bud mesenchyme Weak Single cells 3C (right) , 3C (left) Sporadic expression in fraction of mesenchymal cells.
Specimen 3C (middle): embryonic day 11.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm1Rko/Notch2tm1Rko, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Absent 3C (middle)
Specimen 3D: embryonic day 11.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Haa/Psen2tm1Haa, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: neural tube Strong Regionally restricted 3D (left) , 3D (right) Strong expression in ventral neural tube.
TS19: hindlimb bud ectoderm Present Regionally restricted 3D (left) , 3D (right) Expression in non-AER ectoderm
TS19: hindlimb bud mesenchyme Trace Single cells 3D (right) , 3D (left) Authors report reduction in mesenchymal expression.
Specimen 3D (middle): embryonic day 11.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Haa/Psen2tm1Haa, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 3D (middle)
Specimen 3E (left): embryonic day 11.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm1Rko/Notch2tm1Rko, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present 3E (left)
Specimen 3E (middle): embryonic day 11.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm1Rko/Notch2tm1Rko, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: handplate ectoderm Weak Regionally restricted 3E (middle) Complete absence of expression in ventral ectoderm, but only partial loss in dorsal ectoderm.
TS19: handplate apical ectodermal ridge Absent 3E (middle)
Specimen 3E (right): embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present 3E (right)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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