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Gene Expression Data
Assay Details
Assay
Reference: J:245204 Rashid M, et al., Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development. 2017 Nov 01;144(21):4002-4014
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6509618
Gene symbol: Cux1
Gene name: cut-like homeobox 1
Antibody: anti-Cux1 (CDP, M-222) (sc-13024)
Detection system: Secondary antibody
Results
Specimen 3B PxnF/+: postnatal day 1; Pxntm1.1Cet/Pxn+ (more )
Structure Level Pattern Image Note
TS27: cortical layer II Present 3B PxnF/+
TS27: cortical layer III Present 3B PxnF/+
TS27: cortical layer IV Present 3B PxnF/+
Specimen 3B Nes-Cre:PxnF/F: postnatal day 1; Pxntm1.1Cet/Pxntm1.1Cet, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cortical layer II Present 3B Nes- Cre:PxnF/F
TS27: cortical layer III Present 3B Nes- Cre:PxnF/F
TS27: cortical layer IV Present 3B Nes- Cre:PxnF/F
TS27: neocortex layer Present Regionally restricted 3B Nes- Cre:PxnF/F The mean position of the expressing neurons extends 11.5% deeper compared to control cortices.
Specimen 3H PxnF/+: postnatal day 35; Pxntm1.1Cet/Pxn+ (more )
Structure Level Pattern Image Note
TS28: cortical layer II Present 3H PxnF/+
TS28: cortical layer III Present 3H PxnF/+
TS28: cortical layer IV Present 3H PxnF/+
Specimen 3H Nes-Cre:PxnF/F: postnatal day 35; Pxntm1.1Cet/Pxntm1.1Cet, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cortical layer II Present 3H Nes- Cre:PxnF/F Expression in this mutant is the same as in controls.
TS28: cortical layer III Present 3H Nes- Cre:PxnF/F Expression in this mutant is the same as in controls.
TS28: cortical layer IV Present 3H Nes- Cre:PxnF/F Expression in this mutant is the same as in controls.
Specimen 4A PxnF/F;Hic-5-/-: postnatal day 0; Pxntm1.1Cet/Pxntm1.1Cet, Tgfb1i1tm1.2Cet/Tgfb1i1tm1.2Cet (more )
Structure Level Pattern Image Note
TS27: cortical layer II Present 4A control
TS27: cortical layer III Present 4A control
TS27: cortical layer IV Present 4A control
Specimen 4A Nes-Cre:PxnF/F:Hic-5-/-: postnatal day 0; Pxntm1.1Cet/Pxntm1.1Cet, Tgfb1i1tm1.2Cet/Tgfb1i1tm1.2Cet, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cortical layer II Present 4A dKO
TS27: cortical layer III Present 4A dKO
TS27: cortical layer IV Present 4A dKO
TS27: neocortex layer Present Regionally restricted 4A dKO The mean position of the expressing neurons extends 10% deeper compared to control cortices.
Specimen 4E PxnF/F:Hic-5-/-: postnatal day 35; Pxntm1.1Cet/Pxntm1.1Cet, Tgfb1i1tm1.2Cet/Tgfb1i1tm1.2Cet (more )
Structure Level Pattern Image Note
TS28: cortical layer II Present 4E control
TS28: cortical layer III Present 4E control
TS28: cortical layer IV Present 4E control
Specimen 4E Nes-Cre:PxnF/F:Hic5-/-: postnatal day 35; Pxntm1.1Cet/Pxntm1.1Cet, Tgfb1i1tm1.2Cet/Tgfb1i1tm1.2Cet, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cortical layer II Present 4E dKO Expression in this mutant is the same as in controls.
TS28: cortical layer III Present 4E dKO Expression in this mutant is the same as in controls.
TS28: cortical layer IV Present 4E dKO Expression in this mutant is the same as in controls.
Specimen 5A PxnF/F: postnatal day 1; Pxntm1.1Cet/Pxntm1.1Cet (more )
Structure Level Pattern Image Note
TS27: cortical layer II Present 5A PxnF/F
TS27: cortical layer III Present 5A PxnF/F
TS27: cortical layer IV Present 5A PxnF/F
Specimen 5A NEX-Cre:PxnF/F: postnatal day 1; Neurod6tm1(cre)Kan/Neurod6+, Pxntm1.1Cet/Pxntm1.1Cet (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cortical layer II Present 5A NEX-Cre:PxnF/F
TS27: cortical layer III Present 5A NEX-Cre:PxnF/F
TS27: cortical layer IV Present 5A NEX-Cre:PxnF/F
TS27: neocortex layer Present Regionally restricted 5A NEX-Cre:PxnF/F The mean position of the expressing neurons extends 11.6% deeper compared to control cortices.
Specimen S4A PxnF/F: embryonic day 19.5; Pxntm1.1Cet/Pxntm1.1Cet (more )
Structure Level Pattern Image Note
TS26: neocortex Present Regionally restricted S4A PxnF/F Expression is in neurons in the upper layers.
Specimen S4A Nes-Cre;PxnF/F: embryonic day 19.5; Pxntm1.1Cet/Pxntm1.1Cet, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: neocortex Present S4A Nes-Cre:PxnF/F The mean position of the expressing neurons extends 12% deeper compared to control cortices.
Specimen S4A Hic-5-/-: embryonic day 19.5; Tgfb1i1tm1.2Cet/Tgfb1i1tm1.2Cet (more )
Structure Level Pattern Image Note
TS26: neocortex Present S4A Hic-5-/- Expression in this mutant is the same as in controls.
Specimen not shown Het control P1: postnatal day 1; Pxntm1.1Cet/Pxn+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cortical layer II Present
TS27: cortical layer III Present
TS27: cortical layer IV Present
Specimen not shown Het control E19: embryonic day 19.5; Pxntm1.1Cet/Pxn+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: neocortex Present Expression is in neurons in the upper layers.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory