Pxn^tm1.1Cet
Targeted Allele Detail

Summary

• Symbol: Pxn^tm1.1Cet
• Name: paxillin; targeted mutation 1.1, Christopher E Turner
• MGI ID: MGI:6507432
• Synonyms: Pxn^F
• Gene: Pxn Location: Chr5:115644735-115694046 bp, + strand Genetic Position: Chr5, 56.1 cM
• Alliance: Pxn^tm1.1Cet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245204
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 2, and a second loxP site followed by an FRT-flanked PGK-neo cassette just downstream of exon 5. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 2 through 5 floxed. (J:245204)

Expression

In Mice Carrying this Mutation:

99 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pxn Mutation: 60 strains or lines available

References

• Original: J:245204 Rashid M, et al., Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development. 2017 Nov 01;144(21):4002-4014
• All: 6 reference(s)