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Gene Expression Data
Assay Details
Assay
Reference: J:140709 Nelson LT, et al., Generation and expression of a Hoxa11eGFP targeted allele in mice. Dev Dyn. 2008 Nov;237(11):3410-6
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6500977
Gene symbol: Hoxa11
Gene name: homeobox A11
Reporter: GFP
Direct Detection
Assay notes: Fixative was formalin or 4% paraformaldehyde.
Results
Specimen not shown E9.0: embryonic day 9.0; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS14: embryo Present
Specimen 1A/B: embryonic day 9.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS15: forelimb bud Present 1A/B
TS15: neural tube Present 1A/B
TS15: tail Present Regionally restricted 1A/B Expression is at the tip of the tail.
Specimen 1D: embryonic day 10.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS17: tail Strong 1D
TS17: forelimb bud Strong Regionally restricted 1D Expression is at the distal end.
TS17: hindlimb bud Strong Regionally restricted 1D Expression is at the distal end.
TS17: neural tube Present 1D
TS17: embryo mesoderm Present Regionally restricted 1D Expression is in the flank mesoderm from the mid-hindlimb region to the posterior tip of the tail.
Specimen 1E/F: embryonic day 11.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS19: limb Present Regionally restricted 1E/F Expression is in a more proximal region.
TS19: tail Present 1E/F
TS19: autopod Weak 1E/F
Specimen 1G/H: embryonic day 12.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS20: limb Present Regionally restricted 1G/H Expression is in a more proximal region.
TS20: tail Present 1G/H
TS20: autopod Weak 1G/H
Specimen 1J: embryonic day 13.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS21: limb Present Regionally restricted 1J Expression is in a more proximal region.
TS21: autopod Weak 1J
TS21: tail Weak 1J
Specimen 1K/L: embryonic day 15.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS23: limb Present Regionally restricted 1K/L Expression is in a more proximal region.
TS23: spinal cord Present 1K/L
TS23: autopod Weak 1K/L
TS23: tail Weak 1K/L
Specimen 2A: embryonic day 10.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Present Regionally restricted 2A Expression is uniform in the distal limb bud and in a subset of cells proximally.
Specimen 2B: embryonic day 11.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Note: Double labeled: green - Hoxa11 reporter; red - Sox9 (assay MGI:6500978).
Structure Level Pattern Image Note
TS19: forelimb bud Present Regionally restricted 2B Expression is uniform in the distal limb bud and in a subset of cells proximally and is absent in the center of the proximal limb.
Specimen 2C: embryonic day 12.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS20: zeugopod Present 2C
TS20: autopod Weak 2C
TS20: forelimb interdigital region mesenchyme Weak 2C
Specimen 2E: embryonic day 13.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Note: Double labeled: green - Hoxa11 reporter; red - Sox9 (assay MGI:6500978).
Structure Level Pattern Image Note
TS21: forelimb mesenchyme Present Regionally restricted 2E Expression is distal surrounding the distal radius and ulna in perichondrial regions.
TS21: zeugopod Present Regionally restricted 2E Expression is distal surrounding the distal radius and ulna in perichondrial regions.
TS21: radius-ulna cartilage condensation Present Regionally restricted 2E Expression is at the distal ends of the developing radius and ulna.
TS21: forelimb interdigital region Weak 2E
Specimen 2F: embryonic day 15.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS23: forelimb mesenchyme Present Regionally restricted 2F Expression is distal surrounding the distal radius and ulna in perichondrial regions.
TS23: zeugopod Present Regionally restricted 2F Expression is distal surrounding the distal radius and ulna in perichondrial regions.
TS23: hand mesenchyme Present Regionally restricted 2F Expression is in cells surrounding the condensing digit cartilage.
Specimen 3A: embryonic day 10.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS17: metanephric mesenchyme Present Regionally restricted 3A Expression is in the condensing metanephric mesenchyme.
TS17: ureteric bud Absent 3A
Specimen 3B: embryonic day 11.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS19: metanephric mesenchyme Present Regionally restricted 3B Expression is in the condensing metanephric mesenchyme.
TS19: ureteric bud Absent 3B
Specimen 3C: embryonic day 12.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS20: mesenchyme of metanephros Present Regionally restricted 3C Expression is in the condensing nephrogenic mesenchyme surrounding the ureteric bud.
Specimen 3D: embryonic day 13.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Note: Double labeled: green - Hoxa11 reporter; red - Pax2 (assay MGI:6500979).
Structure Level Pattern Image Note
TS21: mesenchyme of metanephros Present Regionally restricted 3F , 3D Expression is in the condensing nephrogenic mesenchyme surrounding the ureteric bud and surrounding the ureter.
TS21: ureteric tip Absent 3D , 3F
Specimen 3G: embryonic day 15.0; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS23: mesenchyme of metanephros Present 3G Expression is in the condensing nephrogenic mesenchyme cells and in mesenchyme surrounding the ureteric bud.
TS23: ureteric tip Absent 3G
Specimen 3H: embryonic day 16.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Note: Double labeled with peanut agglutinin (PNA, red).
Structure Level Pattern Image Note
TS24: early nephron Present Regionally restricted 3H Expression is in the nephrogenic progenitor cells.
TS24: cortical renal tubule Present Regionally restricted 3H There is some expression in convoluted tubules.
Specimen 4A: embryonic day 16.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS24: uterus Present 4A
TS24: ovary Absent 4A
Specimen 4B: embryonic day 16.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS24: ductus deferens Very strong 4B
Specimen 4C: postnatal day 1; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS27: uterus Strong 4C
TS27: ovary Absent 4C
Specimen 4D: postnatal day 1; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS27: ductus deferens Very strong 4D
Specimen 4E: postnatal day 28; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS28: uterus Strong 4E
TS28: ovary Absent 4E
Specimen 4F: postnatal day 28; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS28: ductus deferens Very strong 4F
Specimen 4G: postnatal month 10; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS28: uterus Strong 4G
TS28: ovary Absent 4G
Specimen 4H: postnatal month 10; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS28: ductus deferens Very strong 4H
Specimen 5A: embryonic day 11.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS19: neural tube basal columns Present 5A
Specimen 5B: embryonic day 12.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted 5B Expression is in dorsal and medial regions.
Specimen 5C: embryonic day 13.5; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS21: spinal cord Present Regionally restricted 5C Expression is in dorsal and medial regions.
Specimen not shown, newborn: postnatal newborn; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS27: limb Present
TS27: spinal cord Present
TS27: tail Present
Specimen not shown P8: postnatal day 8; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS28: early nephron Present Regionally restricted Expression in the nephrogenic progenitor cells is maintained through P8 and is absent after this stage.
Specimen not shown P: postnatal; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS28: early nephron Absent Expression in the nephrogenic progenitor cells is maintained through P8 and is absent after this stage.
Specimen not shown Female Adult: postnatal adult; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS28: uterus Strong
Specimen not shown Male Adult: postnatal adult; Hoxa11tm1Dmwe/Hoxa11+ (more )
Structure Level Pattern Image Note
TS28: ductus deferens Strong
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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