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Gene Expression Data
Assay Details
Assay
Reference: J:193583 Cai Y, et al., Nuclear receptor COUP-TFII-expressing neocortical interneurons are derived from the medial and lateral/caudal ganglionic eminence and define specific subsets of mature interneurons. J Comp Neurol. 2013 Feb 1;521(2):479-97
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6490540
Gene symbol: Sp8
Gene name: trans-acting transcription factor 8
Antibody: Sp8 (C-18): sc-104661
Detection system: Secondary antibody
Results
Specimen 7F: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Shhtm2(cre/ERT2)Cjt/Shh+ (more )
Note: Conditional mutant. Double labeled: magenta - Sp8; green - Cre reporter (Shh).
Structure Level Pattern Image Note
TS19: telencephalon Present Regionally restricted 7F Not expressed in the cell stream migrating from the preoptic area and ventral medial ganglionic eminence into the lateral ganglionic eminence.
Specimen 11A: embryonic day 13.5 (more )
Note: Double labeled: magenta - Sp8; green - Nkx2-1 (assay MGI:6490543).
Structure Level Pattern Image Note
TS21: caudal ganglionic eminence Present Regionally restricted 11A Expressed in the dorsal region.
TS21: lateral ganglionic eminence Present Regionally restricted 11A Expressed in the dorsal region.
TS21: medial ganglionic eminence Absent 11A
Specimen 11B: embryonic day 15.5 (more )
Note: Double labeled: magenta - Sp8; green - Nkx2-1 (assay MGI:6490543).
Structure Level Pattern Image Note
TS23: caudal ganglionic eminence Present Regionally restricted 11B Expressed in the dorsal region.
TS23: lateral ganglionic eminence Present Regionally restricted 11B Expressed in the dorsal region.
TS23: medial ganglionic eminence Absent 11B
Specimen 11C: embryonic day 16.5 (more )
Note: Double labeled: magenta - Sp8; green - Nkx2-1 (assay MGI:6490543).
Structure Level Pattern Image Note
TS24: caudal ganglionic eminence Present Regionally restricted 11C Expressed in the dorsal region.
TS24: lateral ganglionic eminence Present Regionally restricted 11C Expressed in the dorsal region.
TS24: medial ganglionic eminence Absent 11C
Specimen not shown: embryonic day 16.5 (more )
Note: Double labeled with histone H3.
Structure Level Pattern Image Note
TS24: lateral ganglionic eminence Present Regionally restricted Sp8+pH3+ cells were seen in the subventricular zone of the dorsal region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory