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Gene Expression Data
Assay Details
Assay
Reference: J:284738 Devlin LA, et al., Embryonic and foetal expression patterns of the ciliopathy gene CEP164. PLoS One. 2020;15(1):e0221914
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6488228
Gene symbol: Cep164
Gene name: centrosomal protein 164
Reporter: lacZ
Direct Detection
Results
Specimen 1E: postnatal day 1.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS27: renal vesicle Present 1E I , 1E II
TS27: s-shaped body Present 1E I
TS27: metanephros Present Regionally restricted 1E I , 1E III Expression is seen in the developing mesonephric uretric bud.
TS27: renal tubule Present 1E I , 1E IV Expression is seen in nephron segments in both the cortex and medulla.
TS27: maturing glomerular tuft Present 1E V , 1E I Expression is seen in the glomerulus of the developing immature renal corpuscle.
TS27: glomerular tuft Absent 1E I , 1E VI Expression is lost in the glomerulus of the mature renal corpusule.

Specimen 1F - I: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: renal tubule Present 1F I Expression is seen in nephron segments in both the cortex and medulla.
TS28: glomerular tuft Absent 1F I , 1F II Expression is lost in the glomerulus of the mature renal corpusule.
TS28: cortical renal tubule Present 1F III , 1F I

Specimen 1F - IV: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: medullary tubule Present 1F IV

Specimen 2B - I: postnatal day 1.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS27: retina ganglion cell layer Strong 2B I
TS27: retina inner plexiform layer Present 2B I
TS27: retina outer nuclear layer Present 2B I Expression is seen in retinal precursor cells throughout the outer neuroblastic cell layer.
TS27: pigmented retinal epithelium Present 2B I

Specimen 2B - II: postnatal day 15.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Strong 2B II
TS28: photoreceptor layer inner segment Present 2B II
TS28: retina inner plexiform layer Present Punctate 2B II There is sparse expression in some cells; however, these are at the boundaries of the layers.
TS28: retina outer plexiform layer Present Punctate 2B II There is sparse expression in some cells; however, these are at the boundaries of the layers.
TS28: retina nuclear layer Present Regionally restricted 2B II Expression is seen at the edge of the nuclear cell layers.
TS28: pigmented retinal epithelium Strong 2B II

Specimen 2B - III: postnatal day 29.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Strong 2B III
TS28: photoreceptor layer inner segment Present 2B III
TS28: retina inner plexiform layer Present Punctate 2B III There is sparse expression in some cells; however, these are at the boundaries of the layers.
TS28: retina outer plexiform layer Present Punctate 2B III There is sparse expression in some cells; however, these are at the boundaries of the layers.
TS28: pigmented retinal epithelium Strong 2B III
TS28: retina nuclear layer Present Regionally restricted 2B III Expression is seen at the edge of the layer.

Specimen 3G: postnatal day 0.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS27: brain Present Widespread 3G I
TS27: cerebral cortex Present 3G I
TS27: corpus striatum Present 3G I
TS27: telencephalon Present 3G II , 3G I Expression is seen in the cerebrum.
TS27: midbrain Present 3G I
TS27: choroid plexus Present 3G I , 3G III , 3G II
TS27: cerebellum molecular layer Present 3G II , 3G I , 3G IV
TS27: retina ganglion cell layer Present 3G V , 3G I
TS27: cerebral hemisphere Present 3G VI , 3G I
TS27: pons Present 3G I , 3G VII
TS27: medulla oblongata Present 3G I , 3G VIII
TS27: cerebellum white matter Weak 3G IV , 3G I

Specimen 3H: postnatal day 0.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS27: cerebellum molecular layer Present 3H I , 3H II
TS27: hindbrain ventricular layer Present 3H III , 3H I
TS27: 4th ventricle choroid plexus Present 3H I , 3H IV
TS27: pons Present 3H I , 3H V
TS27: cerebellum white matter Weak 3H I , 3H VI

Specimen 3I - I: postnatal day 15.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: cerebellum molecular layer Present 3I I , 3I II
TS28: cerebellum Purkinje cell layer Present 3I I , 3I II
TS28: cerebellum white matter Present 3I I , 3I III

Specimen 3I - IV: postnatal day 15.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: brain Present Widespread 3I IV
TS28: cerebral cortex Present 3I V , 3I IV
TS28: corpus striatum Present 3I V , 3I IV
TS28: telencephalon Present 3I V , 3I IV Expression is seen in the cerebrum.
TS28: midbrain Present 3I VII , 3I IV , 3I VIII Areas of expression include strong, defined expression in the ventricular neuroepithelium surrounding the aquaduct.
TS28: thalamus Present 3I IV , 3I VI
TS28: diencephalon ventricular layer Present 3I IV , 3I VII There is strong, defined expression in the ventricular neuroepithelium.

Specimen 3J - I: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: cerebellum molecular layer Present 3J II , 3J I
TS28: cerebellum Purkinje cell layer Present 3J II , 3J I
TS28: cerebellum granule cell layer Present 3J I , 3J II
TS28: cerebellum white matter Absent 3J III , 3J I

Specimen 3J - IV: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: brain Present Widespread 3J IV
TS28: cerebral cortex Present 3J IV , 3J V
TS28: corpus striatum Present 3J V , 3J IV
TS28: telencephalon Present 3J IV Expression is seen in the cerebrum.
TS28: midbrain Present 3J VI , 3J IV
TS28: pons Present 3J VII , 3J IV
TS28: thalamus Present 3J IV
TS28: medulla oblongata Present 3J IV

Specimen 4B: postnatal day 0.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS27: costal cartilage Present 4B I , 4B II
TS27: intercostal muscle Present 4B III , 4B I

Specimen 4C - I: postnatal day 15.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde. The labels on the inserts in C.I and C.II are incorrect.
Structure Level Pattern Image Note
TS28: bronchus epithelium Present 4C I
TS28: trachea cartilage Present 4C II , 4C III , 4C I
TS28: trachea epithelium Present 4C II , 4C III , 4C I
TS28: bronchiole epithelium Present 4C IV , 4C I
TS28: bronchiole smooth muscle Present 4C IV , 4C I
TS28: respiratory bronchiole epithelium Present 4C I , 4C V
TS28: terminal bronchiole epithelium Present 4C I , 4C V
TS28: alveolus epithelium Weak 4C I , 4C VI

Specimen 4C - VII: postnatal day 15.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Present 4C VIII , 4C VII Expression is seen in cardiomyocytes.

Specimen 4C - IX: postnatal day 15.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Cell Type Level Pattern Image Note
TS28: spermatid Strong 4C IX
TS28: spermatogonium Weak 4C IX
TS28: peritubular myoid cell peritubular myoid cell Present 4C IX Expression is seen in the smooth muscle cells.
TS28: seminiferous tubule Present 4C IX
TS28: rete testis Present 4C IX Expression is seen in the connecting tubules.

Specimen 4C - X: postnatal day 15.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Cell Type Level Pattern Image Note
TS28: spermatid Strong 4C X
TS28: spermatocyte Weak 4C X
TS28: spermatogonium Weak 4C X
TS28: Leydig cell Leydig cell Present 4C X
TS28: peritubular myoid cell peritubular myoid cell Present 4C X Expression is seen in the smooth muscle cells.
TS28: seminiferous tubule Present 4C X

Specimen 4C - XI: postnatal day 15.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Cell Type Level Pattern Image Note
TS28: spermatid Strong 4C XI
TS28: spermatocyte Weak 4C XI
TS28: spermatogonium Weak 4C XI
TS28: peritubular myoid cell peritubular myoid cell Present 4C XI Expression is seen in the smooth muscle cells.
TS28: seminiferous tubule Present 4C XI

Specimen 4C - XII: postnatal day 15.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: hepatic portal vein Present Regionally restricted 4C XII Expression is seen in the epithelial cells lining the hepatic portal veins.
TS28: liver Absent 4C XIV , 4C XII There is no expression in the hepatocytes.
TS28: bile duct Strong 4C XIII , 4C XII Expression is seen in cells lining the ciliated cholangiocyte cells of the bile duct.

Specimen 4D - I: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: bronchus epithelium Present 4D I
TS28: trachea epithelium Present 4D II , 4D I
TS28: trachea cartilage Present 4D II , 4D I , 4D III
TS28: bronchiole epithelium Present 4D I , 4D IV
TS28: bronchiole smooth muscle Present 4D I , 4D IV
TS28: reproductive system epithelium Present 4D V , 4D I
TS28: respiratory bronchiole epithelium Present 4D VI , 4D I
TS28: terminal bronchiole epithelium Present 4D VI , 4D I
TS28: alveolus epithelium Absent 4D VII , 4D I

Specimen 4D - VIII: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Present 4D VIII , 4D IX Expression is seen in cardiomyocytes.

Specimen 4D - X: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Cell Type Level Pattern Image Note
TS28: spermatid Present 4D X
TS28: spermatocyte Present 4D X
TS28: spermatogonium Present 4D X
TS28: peritubular myoid cell peritubular myoid cell Present 4D X Expression is seen in the smooth muscle cells.
TS28: seminiferous tubule Present 4D X

Specimen 4D - XI: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Cell Type Level Pattern Image Note
TS28: spermatid Present 4D XI
TS28: spermatocyte Present 4D XI
TS28: spermatogonium Present 4D XI
TS28: peritubular myoid cell peritubular myoid cell Present 4D XI Expression is seen in the smooth muscle cells.

Specimen 4D - XII: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Cell Type Level Pattern Image Note
TS28: spermatid Present 4D XII
TS28: spermatocyte Present 4D XII
TS28: spermatogonium Present 4D XII
TS28: peritubular myoid cell peritubular myoid cell Present 4D XII Expression is seen in the smooth muscle cells.

Specimen 4D - XIII: postnatal day 30.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS28: liver Absent 4D XIV , 4D XIII There is no expression in the hepatocytes.

Specimen S6A - I: embryonic day 9.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS15: future forebrain Present S6A I
TS15: future hindbrain Present S6A I
TS15: future midbrain Present S6A I
TS15: 1st branchial arch Present S6A I
TS15: 2nd branchial arch Present S6A I
TS15: future spinal cord Present S6A I Expression is seen in the neural tube.
TS15: forelimb bud Present S6A I
TS15: hindlimb ridge Present S6A I
TS15: organ Present S6A I Expression is seen in organ primordia.

Specimen S6A - II: embryonic day 9.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS15: neural ectoderm Present Regionally restricted S6A II Expression is seen in the neuroepithelium surrounding the anterior neuropore.
TS15: future spinal cord Present S6A II Expression is seen in the neural tube.
TS15: hindlimb ridge Present S6A II

Specimen S6A - III: embryonic day 9.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS15: outflow tract Present S6A III
TS15: bulbus cordis Present S6A III
TS15: primitive ventricle Present S6A III Expression is seen in the central ventricle.

Specimen S6A - IV: embryonic day 9.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS15: hindlimb ridge Present S6A IV

Specimen S6B: embryonic day 10.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS17: forebrain Present S6B
TS17: hindbrain Present S6B
TS17: midbrain Present S6B
TS17: 1st branchial arch Present S6B
TS17: 2nd branchial arch Present S6B
TS17: optic cup Present S6B
TS17: nasal pit Present S6B
TS17: forelimb bud Present S6B
TS17: hindlimb bud Present S6B
TS17: primitive ventricle Present S6B
TS17: future spinal cord Present S6B
TS17: organ Present S6B Expression is seen in organ primordia.

Specimen S6C - I: embryonic day 12.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS20: cerebral cortex Present S6C I
TS20: hindbrain Present S6C I
TS20: midbrain Present S6C I
TS20: otic capsule Present S6C I Expression is seen in the otocyst.
TS20: heart Present S6C I
TS20: forelimb Present S6C I
TS20: hindlimb Present S6C I
TS20: spinal cord Present S6C I

Specimen S6C - II: embryonic day 12.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS20: spinal cord Present S6C II
TS20: vertebral cartilage condensation Present S6C II

Specimen S6C - III: embryonic day 12.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS20: cerebral cortex Present S6C III
TS20: hindbrain Present S6C III
TS20: midbrain Present S6C III
TS20: medulla oblongata Present S6C III
TS20: pons Present S6C III
TS20: otic capsule Present S6C III Expression is seen in the otocyst.

Specimen S6C - IV: embryonic day 12.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS20: retina Present S6C IV

Specimen S6C - V: embryonic day 12.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS20: forelimb digit Present Regionally restricted S6C V Expression is seen in the tips of the developing digits, where the apical ectodermal ridge is present.

Specimen S6C - VI: embryonic day 12.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS20: forelimb digit Present Regionally restricted S6C VI Expression is seen in the tips of the developing digits, where the apical ectodermal ridge is present.

Specimen S6C - VII: embryonic day 12.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS20: hindlimb digit Present Regionally restricted S6C VII Expression is seen in the tips of the developing digits, where the apical ectodermal ridge is present.

Specimen S6C - VIII: embryonic day 12.5; Cep164tm1a(EUCOMM)Wtsi/Cep164+ (more )
Note: Tissue fixed in 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS20: hindlimb digit Present Regionally restricted S6C VIII Expression is seen in the tips of the developing digits, where the apical ectodermal ridge is present.


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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory