Gene Expression Data
Assay Details
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Assay
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Reference:
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J:59472
Dou CL, et al., Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres. Cereb Cortex. 1999 Sep;9(6):543-50
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Assay type:
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In situ reporter (knock in)
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MGI Accession ID:
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MGI:6478837
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Gene symbol:
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Foxg1
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Gene name:
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forkhead box G1
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Reporter:
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lacZ
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Direct Detection
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Results
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Specimen
1-3 somite stage not shown:
embryonic day 8.0; Foxg1tm1M/Foxg1 +
(more  )
Specimen
1-3 somite stage not shown:
(close  )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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embryonic day 8.0
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Age Note:
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Age assigned by curator based on morphological criteria supplied by authors.
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS12: head surface ectoderm |
Present |
Regionally restricted |
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Expression first detected in anterior surface ectoderm adacent to rostral neural plate.
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Specimen
2A:
embryonic day 8.0; Foxg1tm1M/Foxg1 +
(more )
Note: 3-5 somite stage
Specimen
2A:
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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embryonic day 8.0
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Age Note:
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Age assigned by curator based on morphological criteria supplied by authors.
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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Note:
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3-5 somite stage
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| Structure |
Level |
Pattern |
Image |
Note |
| TS12: head surface ectoderm |
Present |
Regionally restricted |
2A
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Stronger and more uniform expression in anterior surface ectoderm immediately adjacent to rostral neural plate.
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Specimen
2B:
embryonic day 8.0; Foxg1tm1M/Foxg1 +
(more )
Note: 7-8 somite stage
Specimen
2B:
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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embryonic day 8.0
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Age Note:
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Age assigned by curator based on morphological criteria supplied by authors.
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Note:
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7-8 somite stage
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| Structure |
Level |
Pattern |
Image |
Note |
| TS12: surface ectoderm |
Present |
Regionally restricted |
2B
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Expression in surface ectoderm spreading laterally
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| TS12: future brain |
Present |
Regionally restricted |
2B
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Expression first observed in scattered cells along lateral edge of rostral margin of neural plate.
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| TS12: embryo endoderm |
Present |
Regionally restricted |
2B
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Expression in most rostral endoderm.
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Specimen
2C:
embryonic day 8.5; Foxg1tm1M/Foxg1 +
(more )
Note: 10 somite stage
Specimen
2C:
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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embryonic day 8.5
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Age Note:
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Age assigned by curator based on morphological criteria supplied by authors.
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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Note:
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10 somite stage
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| Structure |
Level |
Pattern |
Image |
Note |
| TS13: surface ectoderm |
Present |
Regionally restricted |
2C
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Surface ectoderm expression spreading laterally and caudally. Expression in anterolateral surface ectoderm.
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| TS13: future brain |
Present |
Regionally restricted |
2C
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Uniform band of expression at rostral edge of neural plate.
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Specimen
2D:
embryonic day 9.0; Foxg1tm1M/Foxg1 +
(more )
Specimen
2D:
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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embryonic day 9.0
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS14: future telencephalon |
Present |
Regionally restricted |
2D
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Expression domain in telencephalic neuroepithelium, including progenitor cells of cerebral cortex, basal ganglia and olfactory bulbs.
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Specimen
2E:
embryonic day 9.5; Foxg1tm1M/Foxg1 +
(more )
Specimen
2E:
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: telencephalon |
Present |
Graded |
2E
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Shallow dorsal-ventral gradient of expression. Modestly higher expression in ventral telencephalon.
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Specimen
2F:
postnatal month 4; Foxg1tm1M/Foxg1 +
(more )
Specimen
2F:
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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postnatal month 4
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: telencephalon |
Present |
Regionally restricted |
2F
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Expression restricted ot cells derived from telencephalic neuroepithelium, including cerebral cortex and hippocampus.
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| TS28: cerebral cortex |
Present |
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2F
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| TS28: hippocampus CA1 |
Strong |
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2F
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In pyramidal cells of hippocampus, highest expression in CA1 cells.
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Specimen
3A:
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1tm1M
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: telencephalon |
Present |
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3A
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Dorsal telencephalon is reduced in size. Ganglionic eminence is essentially absent.
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Specimen
3B:
embryonic day 12.5; Foxg1tm1M/Foxg1 +
(more )
Specimen
3B:
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Specimen
3C (left):
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1tm1M
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: telencephalon |
Present |
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3C (left)
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Minimal difference in size of telencephalic vesicle between homozygote and heterozygote.
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Specimen
3C (rightO:
embryonic day 9.5; Foxg1tm1M/Foxg1 +
(more )
Specimen
3C (rightO:
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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Specimen
3D (left):
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1tm1M
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Age:
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embryonic day 10.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS17: telencephalon |
Present |
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3D (left)
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Growth of telencephalic vesicle is progressively retarded relative to heterozygote.
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Specimen
3D (right):
embryonic day 10.5; Foxg1tm1M/Foxg1 +
(more )
Specimen
3D (right):
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Foxg1tm1M/Foxg1+
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Age:
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embryonic day 10.5
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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4% Paraformaldehyde
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Analysis Tools
