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Gene Expression Data
Assay Details
Assay
Reference: J:266577 Rodrigo Albors A, et al., Lineage tracing of axial progenitors using Nkx1-2CreER(T2) mice defines their trunk and tail contributions. Development. 2018 Oct 2;145(19):dev164319
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6471020
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2 (AB5603)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2A rostral node: embryonic day 8.5 (more )
Note: Double labeled: blue - Sox2; red - T (assay MGI:6471021).
Structure Level Pattern Image Note
TS13: neural plate Present 2A rostral node SOX2 , 2A rostral node (merge)
Specimen 2A NSB: embryonic day 8.5 (more )
Note: Double labeled: blue - Sox2; red - T (assay MGI:6471021).
Structure Level Pattern Image Note
TS13: neural plate Present 2A NSB (merge) , 2A NSB SOX2
TS13: embryo ectoderm Present Regionally restricted 2A NSB SOX2 , 2A NSB (merge) Co-expression with T (brachyury) in cells at midline of epiblast of NSB (node-streak border)
Specimen 2A streak and CLE: embryonic day 8.5 (more )
Note: Double labeled: blue - Sox2; red - T (assay MGI:6471021).
Structure Level Pattern Image Note
TS13: neural plate Present 2A streak and CLE (merge) , 2A streak and CLE SOX2
TS13: embryo ectoderm Present Regionally restricted 2A streak and CLE SOX2 , 2A streak and CLE (merge) Co-expression with T (brachyury) posteriorly in CLE (caudal lateral epiblast).
TS13: primitive streak Present Regionally restricted 2A streak and CLE SOX2 , 2A streak and CLE (merge) Co-expression with T (brachyury) in primitive streak.
Specimen 2B (1st row): embryonic day 10.5 (more )
Note: Double labeled: blue - Sox2; red - T (assay MGI:6471021).
Structure Level Pattern Image Note
TS17: neural tube Present 2B 1st row (merge) , 2B 1st row SOX2
Specimen 2B (2nd row): embryonic day 10.5 (more )
Note: Double labeled: blue - Sox2; red - T (assay MGI:6471021).
Structure Level Pattern Image Note
TS17: neural tube Present 2B 2nd row SOX2 , 2B 2nd row (merge)
TS17: unsegmented mesenchyme Absent 2B 2nd row SOX2 , 2B 2nd row (merge) No expression in presomitic mesoderm cells.
Specimen 2B (3rd row): embryonic day 10.5 (more )
Note: Double labeled: blue - Sox2; red - T (assay MGI:6471021).
Structure Level Pattern Image Note
TS17: embryo mesenchyme Present Regionally restricted 2B 3rd row SOX2 , 2B 3rd row (merge) Expression in putative NMPs (neuromesodermal progenitors) in dorsal half of CNH (chordo-neural hinge), including cells in the neural tube and mesenchymal cells directly below neural tube. Authors refer to this medial mesenchymal poputlation as the neuromesodermal lip.
TS17: neural tube Present Regionally restricted 2B 3rd row SOX2 , 2B 3rd row (merge) Expression in putative NMPs (neuromesodermal progenitors) in dorsal half of CNH (chordo-neural hinge), including cells in the neural tube and mesenchymal cells directly below neural tube. Authors refer to this medial mesenchymal poputlation as the neuromesodermal lip.
Specimen 2B (4th row): embryonic day 10.5 (more )
Note: Double labeled: blue - Sox2; red - T (assay MGI:6471021).
Structure Level Pattern Image Note
TS17: tail mesenchyme Ambiguous 2B 4th row (merge) , 2B 4th row SOX2
Specimen S2A rostral node: embryonic day 8.5 (more )
Note: Double labeled: blue - Sox2; red - Tbx6 (assay MGI:6471022).
Structure Level Pattern Image Note
TS13: neural plate Present S2A rostral node (merge) , S2A rostral node SOX2
Specimen S2A NSB: embryonic day 8.5 (more )
Note: Double labeled: blue - Sox2; red - Tbx6 (assay MGI:6471022).
Structure Level Pattern Image Note
TS13: neural plate Present S2A NSB (merge) , S2A NSB SOX2
Specimen S2A streak and CLE: embryonic day 8.5 (more )
Note: Double labeled: blue - Sox2; red - Tbx6 (assay MGI:6471022).
Structure Level Pattern Image Note
TS13: neural plate Present S2A streak and CLE (merge) , S2A streak and CLE SOX2
TS13: embryo ectoderm Present Regionally restricted S2A streak and CLE (merge) , S2A streak and CLE SOX2
TS13: primitive streak Present S2A streak and CLE SOX2 , S2A streak and CLE (merge)
Specimen S2B (1st row): embryonic day 10.5 (more )
Note: Double labeled: blue - Sox2; red - Tbx6 (assay MGI:6471022).
Structure Level Pattern Image Note
TS17: neural tube Present S2B 1st row SOX2 , S2B 1st row (merge)
Specimen S2B (2nd row): embryonic day 10.5 (more )
Note: Double labeled: blue - Sox2; red - Tbx6 (assay MGI:6471022).
Structure Level Pattern Image Note
TS17: neural tube Present S2B 2nd row SOX2 , S2B 2nd row (merge)
TS17: unsegmented mesenchyme Absent S2B 2nd row SOX2 , S2B 2nd row (merge) No expression in presomitic mesoderm cells.
Specimen S2B (3rd row): embryonic day 10.5 (more )
Note: Double labeled: blue - Sox2; red - Tbx6 (assay MGI:6471022).
Structure Level Pattern Image Note
TS17: neural tube Present S2B 3rd row (merge) , S2B 3rd row SOX2
Specimen S2B (4th row): embryonic day 10.5 (more )
Note: Double labeled: blue - Sox2; red - Tbx6 (assay MGI:6471022).
Structure Level Pattern Image Note
TS17: tail Ambiguous S2B 4th row (merge) , S2B 4th row SOX2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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