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Gene Expression Data
Assay Details
Assay
Reference: J:282912 Zhang L, et al., Expression Patterns and Potential Biological Roles of Dip2a. PLoS One. 2015;10(11):e0143284
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6436704
Gene symbol: Dip2a
Gene name: disco interacting protein 2 homolog A
Reporter: lacZ
Direct Detection
Results
Specimen 1 E9.5 left: embryonic day 9.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS15: future spinal cord Strong 1_E9.5 left

Specimen 1 E9.5 center: embryonic day 9.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS15: future spinal cord Strong 1_E9.5 center

Specimen 1 E9.5 right: embryonic day 9.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS15: future spinal cord Strong 1_E9.5 right

Specimen 1 E11.5 left: embryonic day 11.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS19: future spinal cord Strong 1_E11.5 left

Specimen 1 E11.5 center: embryonic day 11.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS19: future spinal cord Strong 1_E11.5 center

Specimen 1 E11.5 right: embryonic day 11.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS19: future spinal cord Strong 1_E11.5 right

Specimen 2A: embryonic day 12.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS20: face Present Regionally restricted 2A Expression was detected in snout merkel cells at base of whiskers.
TS20: forelimb Present 2A
TS20: hindlimb Present 2A

Specimen 2B: embryonic day 12.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS20: forelimb Present 2B
TS20: hindlimb Present 2B

Specimen 2C: embryonic day 12.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS20: face Present Regionally restricted 2C Expression was detected in snout merkel cells at base of whiskers.
TS20: forelimb Present 2C
TS20: hindlimb Present 2C

Specimen 2G: embryonic day 15.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS23: cranial ganglion Present 2G
TS23: dorsal root ganglion Present 2G
TS23: trigeminal ganglion Present 2G

Specimen 2H: embryonic day 15.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS23: face Present Regionally restricted 2H Expression was detected in snout merkel cells at base of whiskers.
TS23: forelimb Present 2H
TS23: hindlimb Present 2H
TS23: forelimb phalanx Present Regionally restricted 2H Phalanges of wrists and toes show stronger signal in anterior region than posterior regions.
TS23: hindlimb phalanx Present Regionally restricted 2H Phalanges of wrists and toes show stronger signal in anterior region than posterior regions.

Specimen 2I: embryonic day 15.5; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS23: face Present Regionally restricted 2I Expression was detected in snout merkel cells at base of whiskers.
TS23: forelimb Present 2I
TS23: hindlimb Present 2I
TS23: forelimb phalanx Present Regionally restricted 2I Phalanges of wrists and toes show stronger signal in anterior region than posterior regions.
TS23: hindlimb phalanx Present Regionally restricted 2I Phalanges of wrists and toes show stronger signal in anterior region than posterior regions.

Specimen 3 Lateral: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: brain Strong 3_Lateral

Specimen 3 Ventral: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: brain Strong 3_Ventral

Specimen 3 Dorsal: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: brain Strong 3_Dorsal

Specimen 4: postnatal day 56; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Present 4_P56 Hets brain sagittal section , 4A
TS28: cerebellum Purkinje cell layer Present 4A , 4_P56 Hets brain sagittal section , 4B
TS28: hippocampus Present 4_P56 Hets brain sagittal section , 4C
TS28: pontine nucleus Present 4D , 4_P56 Hets brain sagittal section
TS28: anterior olfactory nucleus Present 4E , 4_P56 Hets brain sagittal section
TS28: main olfactory bulb Present 4F , 4_P56 Hets brain sagittal section
TS28: cerebral cortex Present 4_P56 Hets brain sagittal section , 4G
TS28: corpus striatum Present Regionally restricted 4_P56 Hets brain sagittal section , 4H Expression was detected in ventral striatum.
TS28: cerebellum granule cell layer Present 4I , 4_P56 Hets brain sagittal section

Specimen 7: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: retina nerve fiber layer Strong Regionally restricted 7_ top Retina , 7_top Eye Strong expression was detected in retinal ganglion cells within optic nerve fiber layer.
TS28: retina inner nuclear layer Strong 7_ top Retina , 7_top Eye
TS28: retina outer nuclear layer Strong 7_ top Retina , 7_top Eye

Specimen 8 Whole mount: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: spinal cord Strong Widespread 8_ Whole mount Strong signals were seen throughout the spinal cord.

Specimen 8 Section (Lumbar region): postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: spinal cord Strong Regionally restricted 8_Section (Lumbar region) x20 , 8_Section (Lumbar region) x5.6 Expression was detected in neurons surrounding the central canal.

Specimen 9 Saphaneous vein: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: saphenous vein Present 9_Saphenous vein

Specimen 9 Tail vein: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: tail vein Present 9_Tail vein

Specimen 9 Tail skin vein: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: tail vein Present Regionally restricted 9_Tail skin vein Expression was detected in tail skin vein.

Specimen 9 Valves: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: saphenous vein Present Regionally restricted 9_Valves Expression was detected in valves within the Saphenous vein.

Specimen 10 Whole mount: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: heart Strong 10_Whole mount Strong LacZ activity was observed in cardiomyocytes.

Specimen 10 Section: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: heart Strong 10_Section x5.6 , 10_Section x40 Strong LacZ activity was observed in cardiomyocytes.

Specimen 11 Testis: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: testis Strong 11_Testis

Specimen 11 Seminal vesicle: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: seminal vesicle Strong 11_Seminal vesicle

Specimen 11 Prostate gland: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: prostate gland Strong 11_Prostate gland

Specimen 12 left: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: spermatocyte Strong 12_top left Intense signal was seen in spermatocytes from both testis and epididymis.

Specimen 12 center: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: seminiferous tubule epithelium Strong 12_top center

Specimen 12 right: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: caput epididymis Strong 12_top right

Specimen 13 x5.6: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: seminal vesicle Strong Regionally restricted 13_Seminal vesicle x5.6 Secretory granules of seminal vesicle housed in mucosal folds were strongly positive. No staining was detected in interstitial tissue and eosinophilic secretion of seminal vesicle.

Specimen 13 x20: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: seminal vesicle Strong Regionally restricted 13_Seminal vesicle x20 Secretory granules of seminal vesicle housed in mucosal folds were strongly positive. No staining was detected in interstitial tissue and eosinophilic secretion of seminal vesicle.

Specimen 13 x64: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: seminal vesicle Strong Regionally restricted 13_Seminal vesicle x64 Secretory granules of seminal vesicle housed in mucosal folds were strongly positive. No staining was detected in interstitial tissue and eosinophilic secretion of seminal vesicle.

Specimen 14 Ovary: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: ovary follicle Strong 14_Ovary
TS28: oocyte Strong 14_Oocyte , 14_Ovary

Specimen 14 Uterus: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: endometrium Weak 14_Uterus

Specimen 15 Lung: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: lung Present 15_Lung

Specimen 15 Tongue: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: tongue Present 15_Tongue

Specimen 15 Liver: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: liver Present 15_Liver

Specimen 16 Gall bladder: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: gallbladder Present 16_Gall bladder Both specific and non-specific LacZ activity were seen in gall bladdeer.

Specimen 16 Salivary Gland: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: salivary gland Present 16_Salivary gland Both specific and non-specific LacZ activity were seen in salivary gland.

Specimen 16 Lung: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: lung Present 16_Lung

Specimen 17 Kidney: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: renal tubule Present 17_Kidney

Specimen 17 Glomeruli: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: glomerular tuft Strong 17_Glomeruli

Specimen 17 Renal papilla: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: inner renal medulla Strong Regionally restricted 17_Renal papilla Strong expression was detected in renal papilla in anterior of inner medulla.

Specimen 18 Glandular stomach: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: stomach glandular region Present Regionally restricted 18_Glandular stomach x64 , 18_Glandular stomach x20 Secretive cells of glandular stomach were LacZ positive.

Specimen 18 Ileum: postnatal week 8; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: ileum villus Present Regionally restricted 18_Ileum The columnar absorptive region of intestinal villus was LacZ positive.

Specimen S1 Dip2aLacZ/LacZ: postnatal adult; Dip2aem#bYwz/Dip2aem#bYwz (more )
Structure Level Pattern Image Note
TS28: brain Present S1_Dip2aLacZ/LacZ No obvious differences were observed between homozygous and heterozygous brain except stronger staining in homozygotes.
TS28: cerebellum Present S1A Dip2aLacZ/LacZ , S1B Dip2aLacZ/LacZ
TS28: cerebellum Purkinje cell layer Present S1A Dip2aLacZ/LacZ , S1B Dip2aLacZ/LacZ
TS28: hippocampus Present S1C Dip2aLacZ/LacZ
TS28: pontine nucleus Present S1D Dip2aLacZ/LacZ
TS28: anterior olfactory nucleus Present S1E Dip2aLacZ/LacZ
TS28: main olfactory bulb Present S1F Dip2aLacZ/LacZ
TS28: cerebral cortex Present S1G Dip2aLacZ/LacZ
TS28: corpus striatum Present Regionally restricted S1H Dip2aLacZ/LacZ Expression was detected in ventral striatum.
TS28: cerebellum granule cell layer Present S1I Dip2aLacZ/LacZ

Specimen S1 Dip2aLacZ/WT: postnatal adult; Dip2aem#bYwz/Dip2a+ (more )
Structure Level Pattern Image Note
TS28: brain Present S1_Dip2aLacZ/WT No obvious differences were observed between homozygous and heterozygous brain except stronger staining in homozygotes.
TS28: cerebellum Present S1B Dip2aLacZ/WT , S1A Dip2aLacZ/WT
TS28: cerebellum Purkinje cell layer Present S1B Dip2aLacZ/WT , S1A Dip2aLacZ/WT
TS28: hippocampus Present S1C Dip2aLacZ/WT
TS28: pontine nucleus Present S1D Dip2aLacZ/WT
TS28: anterior olfactory nucleus Present S1E Dip2aLacZ/WT
TS28: main olfactory bulb Present S1F Dip2aLacZ/WT
TS28: cerebral cortex Present S1G Dip2aLacZ/WT
TS28: corpus striatum Present Regionally restricted S1H Dip2aLacZ/WT Expression was detected in ventral striatum.
TS28: cerebellum granule cell layer Present S1I Dip2aLacZ/WT


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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory