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Gene Expression Data
Assay Details
Assay
Reference: J:261117 Sasamoto K, et al., Cdk5 is required for the positioning and survival of GABAergic neurons in developing mouse striatum. Dev Neurobiol. 2017 Apr;77(4):483-492
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6429882
Gene symbol: Th
Gene name: tyrosine hydroxylase
Antibody: anti-TH
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 1A/A' +/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: ventral striatum Present 1A +/+ , 1A' +/+ Expressed in neurons.
Specimen 1A/A' -/-: embryonic day 18.5; Cdk5tm1Kul/Cdk5tm1Kul (more )
Structure Level Pattern Image Note
TS26: ventral striatum Present Regionally restricted 1A' -/- , 1A -/- The distribution was altered in the mutant. The staining revealed the absence of structure of the olfactory tubercles.
Specimen 3B control: postnatal day 1 (more )
Note: Littermate control, but genotype was not specified.
Structure Level Pattern Image Note
TS27: accumbens nucleus Present 3B left Expressed in presynaptic terminals.
TS27: olfactory tubercle Present 3B left Expressed in presynaptic terminals.
Specimen 3B Dlx5/6-p35cKO; p39KO: postnatal day 1; Cdk5r1tm2Ohsh/Cdk5r1tm2Ohsh, Cdk5r2tm1Lht/Cdk5r2tm1Lht, Tg(dlx5a-cre)1Mekk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: accumbens nucleus Absent 3B right
TS27: olfactory tubercle Absent 3B right
Specimen 3C Control: postnatal day 14 (more )
Note: Littermate control, but genotype was not specified.
Structure Level Pattern Image Note
TS28: corpus striatum Present Patchy 3C lower left Exoressed as dopamine islands.
Specimen 3C Dlx5/6-p35cKO; p39KO: postnatal day 14; Cdk5r1tm2Ohsh/Cdk5r1tm2Ohsh, Cdk5r2tm1Lht/Cdk5r2tm1Lht, Tg(dlx5a-cre)1Mekk/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: corpus striatum Present 3C lower right The structure of dopamine islands was unclear.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory