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Gene Expression Data
Assay Details
Assay
Reference: J:139188 Zhao H, et al., TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol. 2008 Aug 1;320(1):19-29
Assay type: RNA in situ
MGI Accession ID: MGI:6390865
Gene symbol: Lef1
Gene name: lymphoid enhancer binding factor 1
Probe: Lef1 probe14
Probe preparation: labelled with digoxigenin DNA
Results
Specimen 2M: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: maxillary process Strong Regionally restricted 2M Strong expression in discrete regions of presumptive tooth germs.
Specimen 2N: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: maxillary process Absent 2N
Specimen 2O: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: mandibular process Strong Regionally restricted 2O Strong expression in discrete regions of presumptive tooth germs.
Specimen 2P: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: mandibular process Absent 2P
Specimen 2Q: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: upper jaw tooth Strong 2Q Strong expression in discrete regions of presumptive tooth germs.
Specimen 2R: embryonic day 13.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: maxilla Absent 2R
Specimen 2S: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw tooth Strong 2S Strong expression in discrete regions of presumptive tooth germs.
Specimen 2T: embryonic day 13.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: mandible Absent 2T
Specimen 2U: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: tooth bud Present 2U Expression in tooth germs.
Specimen 2V: embryonic day 14.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tooth bud Present 2V Expression in tooth germ beginning at E14.5
Specimen 4G: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: tooth bud Present 4G Expression in tooth germs.
Specimen 4H: embryonic day 12.5; Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: tooth bud Present 4H Expression in unaffected in mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory