About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:231098 Theveniau-Ruissy M, et al., Coronary stem development in wild-type and Tbx1 null mouse hearts. Dev Dyn. 2016 Apr;245(4):445-59
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6389829
Gene symbol: Tbx1
Gene name: T-box 1
Reporter: lacZ
Direct Detection
Assay notes: Salmon-gal staining.
Results
Specimen 6A upper left: embryonic day 12.5; Tbx1tm1Bld/Tbx1+ (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present Regionally restricted 6A upper left Expressed in the base.
TS20: pulmonary trunk Present Regionally restricted 6A upper left Expressed in the base.
Specimen 6A upper middle: embryonic day 12.5; Tbx1tm1Bld/Tbx1+ (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present 6A upper middle Expressed in the base. No expression at the position of the right coronary artery.
TS20: pulmonary trunk Present 6A upper middle Expressed in the base.
Specimen 6A upper right: embryonic day 12.5; Tbx1tm1Bld/Tbx1+ (more )
Structure Level Pattern Image Note
TS20: ascending aorta Strong Regionally restricted 6A upper right Expressed in the base. Expressed at the position of the left coronary artery.
TS20: pulmonary trunk Present Regionally restricted 6A upper right Expressed in the base.
Specimen 6A lower left: embryonic day 15.5; Gja5tm1Lumi/Gja5+, Tbx1tm1Bld/Tbx1+ (more )
Note: Double labeled: purple - Tbx1 reporter; green - Gja5 reporter (assay MGI:6389791).
Structure Level Pattern Image Note
TS23: ascending aorta Present 6A lower left
TS23: pulmonary trunk Present 6A lower left
Specimen 6A lower middle: embryonic day 15.5; Gja5tm1Lumi/Gja5+, Tbx1tm1Bld/Tbx1+ (more )
Note: Double labeled: purple - Tbx1 reporter; green - Gja5 reporter (assay MGI:6389791).
Structure Level Pattern Image Note
TS23: pulmonary trunk Present 6A lower middle
TS23: ascending aorta Present Regionally restricted 6A lower middle No expression at the position of the right coronary artery.
Specimen 6A lower right: embryonic day 15.5; Gja5tm1Lumi/Gja5+, Tbx1tm1Bld/Tbx1+ (more )
Note: Double labeled: purple - Tbx1 reporter; green - Gja5 reporter (assay MGI:6389791).
Structure Level Pattern Image Note
TS23: pulmonary trunk Present 6A lower right
TS23: ascending aorta Present 6A lower right Expressed at the position of the left coronary artery.
Specimen 6B upper left: embryonic day 12.5; Tbx1tm1Pa/Tbx1tm1Bld (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present 6B upper left An abnormal residual reporter domain on the left and dorsal sides of the common arterial trunk. No expression is observed on the right side.
Specimen 6B upper middle: embryonic day 12.5; Tbx1tm1Pa/Tbx1tm1Bld (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present 6B upper middle An abnormal residual reporter domain on the left and dorsal sides of the common arterial trunk. No expression is observed on the right side.
Specimen 6B upper right: embryonic day 12.5; Tbx1tm1Pa/Tbx1tm1Bld (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present 6B upper right An abnormal residual reporter domain on the left and dorsal sides of the common arterial trunk. No expression is observed on the right side.
Specimen 6B lower left: embryonic day 15.5; Gja5tm1Lumi/Gja5+, Tbx1tm1Bld/Tbx1tm1Pa (more )
Note: Double labeled: purple - Tbx1 reporter; green - Gja5 reporter (assay MGI:6389791).
Structure Level Pattern Image Note
TS23: ascending aorta Present Regionally restricted 6B lower left Left and right coronary arteries connected ventrally in a common ostium adjacent to a beta-galactosidase negative domain.
Specimen 6B lower middle: embryonic day 15.5; Gja5tm1Lumi/Gja5+, Tbx1tm1Bld/Tbx1tm1Pa (more )
Note: Double labeled: purple - Tbx1 reporter; green - Gja5 reporter (assay MGI:6389791).
Structure Level Pattern Image Note
TS23: ascending aorta Present Regionally restricted 6B lower middle Left and right coronary arteries connected ventrally in a common ostium adjacent to a beta-galactosidase negative domain.
Specimen 6B lower right: embryonic day 15.5; Gja5tm1Lumi/Gja5+, Tbx1tm1Bld/Tbx1tm1Pa (more )
Note: Double labeled: purple - Tbx1 reporter; green - Gja5 reporter (assay MGI:6389791).
Structure Level Pattern Image Note
TS23: ascending aorta Present Regionally restricted 6B lower right Left and right coronary arteries connected ventrally in a common ostium adjacent to a beta-galactosidase negative domain.
Specimen 7C upper left: embryonic day 12.5; Sema3ctm1.1Jra/Sema3ctm1.1Jra, Tbx1tm1Bld/Tbx1+ (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present Regionally restricted 7C upper left A normal pattern with an unlabeled domain on the right side and expression on the left side of the common arterial trunk.
Specimen 7C upper middle: embryonic day 12.5; Sema3ctm1.1Jra/Sema3ctm1.1Jra, Tbx1tm1Bld/Tbx1+ (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present Regionally restricted 7C upper middle A normal pattern with an unlabeled domain on the right side and expression on the left side of the common arterial trunk.
Specimen 7C upper right: embryonic day 12.5; Sema3ctm1.1Jra/Sema3ctm1.1Jra, Tbx1tm1Bld/Tbx1+ (more )
Structure Level Pattern Image Note
TS20: ascending aorta Present Regionally restricted 7C upper right A normal pattern with an unlabeled domain on the right side and expression on the left side of the common arterial trunk.
Specimen 7C lower left: embryonic day 15.5; Gja5tm1Lumi/Gja5+, Sema3ctm1.1Jra/Sema3ctm1.1Jra, Tbx1tm1Bld/Tbx1+ (more )
Note: Double labeled: purple - Tbx1 reporter; green - Gja5 reporter (assay MGI:6389791).
Structure Level Pattern Image Note
TS23: ascending aorta Present Regionally restricted 7C lower left No expression at the position of the right coronary artery.
Specimen 7C lower middle: embryonic day 15.5; Gja5tm1Lumi/Gja5+, Sema3ctm1.1Jra/Sema3ctm1.1Jra, Tbx1tm1Bld/Tbx1+ (more )
Note: Double labeled: purple - Tbx1 reporter; green - Gja5 reporter (assay MGI:6389791).
Structure Level Pattern Image Note
TS23: ascending aorta Present Regionally restricted 7C lower middle No expression at the position of the right coronary artery.
Specimen 7C lower right: embryonic day 15.5; Gja5tm1Lumi/Gja5+, Sema3ctm1.1Jra/Sema3ctm1.1Jra, Tbx1tm1Bld/Tbx1+ (more )
Note: Double labeled: purple - Tbx1 reporter; green - Gja5 reporter (assay MGI:6389791).
Structure Level Pattern Image Note
TS23: ascending aorta Present 7C lower right Expressed at the position of the left coronary artery.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory