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Gene Expression Data
Assay Details
Assay
Reference: J:273626 Wang K, et al., Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development. BMC Dev Biol. 2019 Mar 25;19(1):5
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6388789
Gene symbol: Igf1r
Gene name: insulin-like growth factor I receptor
Antibody: anti-p-IGF-IR (Tyr 1161): sc-101703
Detection system: Secondary antibody coupled to Alexa Fluor 546
Results
Specimen 2 E11.5 Control: embryonic day 11.5; Igf2tm1Cons/Igf2tm1Cons (more )
Structure Level Pattern Image Note
TS19: ventricle cardiac muscle Present 2_E11.5 control middle lower , 2_E11.5 control middle upper
TS19: ventricle endocardial lining Present 2_E11.5 control middle lower , 2_E11.5 control middle upper
TS19: ascending aorta Present Regionally restricted 2_E11.5 control middle upper , 2_E11.5 control middle lower Expressed in coronary blood vessel endothelium.
Specimen 2 E11.5 Igf2 cKO: embryonic day 11.5; Igf2tm1Cons/Igf2tm1Cons, Nkx2-5tm1(cre)Rjs/Nkx2-5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: heart ventricle Absent 2_E11.5 cKO left upper , 2_E11.5 cKO left lower
Specimen 2 E12.5 Control: embryonic day 12.5; Igf2tm1Cons/Igf2tm1Cons (more )
Structure Level Pattern Image Note
TS20: ventricle cardiac muscle Present 2_E12.5 control middle upper , 2_E12.5 control middle lower
TS20: ventricle endocardial lining Present 2_E12.5 control middle upper , 2_E12.5 control middle lower
TS20: ascending aorta Present Regionally restricted 2_E12.5 control middle lower , 2_E12.5 control middle upper Expressed in coronary blood vessel endothelium.
Specimen 2 E12.5 Igf2 cKO: embryonic day 12.5; Igf2tm1Cons/Igf2tm1Cons, Nkx2-5tm1(cre)Rjs/Nkx2-5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: heart ventricle Absent 2_E12.5 cKO left upper , 2_E12.5 cKO left lower
Specimen 2 E14.5 Control: embryonic day 14.5; Igf2tm1Cons/Igf2tm1Cons (more )
Structure Level Pattern Image Note
TS22: ventricle cardiac muscle Present 2_E14.5 control middle lower , 2_E14.5 control middle upper
TS22: ventricle endocardial lining Present 2_E14.5 control middle lower , 2_E14.5 control middle upper
TS22: coronary artery Present Regionally restricted 2_E14.5 control middle lower , 2_E14.5 control middle upper Expressed in coronary blood vessel endothelium.
Specimen 2 E14.5 Igf2 cKO: embryonic day 14.5; Igf2tm1Cons/Igf2tm1Cons, Nkx2-5tm1(cre)Rjs/Nkx2-5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: heart ventricle Absent 2_E14.5 cKO left upper , 2_E14.5 cKO left lower
Specimen 4 E14.5 Control: embryonic day 14.5; Igf1rtm1Jcbr/Igf1rtm1Jcbr (more )
Structure Level Pattern Image Note
TS22: ventricle cardiac muscle Present 4_E14.5 control left lower , 4_E14.5 control left upper
TS22: ventricle endocardial lining Present 4_E14.5 control left lower , 4_E14.5 control left upper
TS22: coronary artery Present Regionally restricted 4_E14.5 control left lower , 4_E14.5 control left upper Expressed in coronary blood vessel endothelium.
Specimen 4 E14.5 Igf1r cKO: embryonic day 14.5; Igf1rtm1Jcbr/Igf1rtm1Jcbr, Nkx2-5tm1(cre)Rjs/Nkx2-5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: ventricle cardiac muscle Absent 4_E14.5 cKO left upper , 4_E14.5 cKO left lower
TS22: ventricle endocardial lining Trace Scattered 4_E14.5 cKO left upper , 4_E14.5 cKO left lower Some residual positive expression.
TS22: coronary artery Present Regionally restricted 4_E14.5 cKO left upper , 4_E14.5 cKO left lower Expressed normally in coronary blood vessel endothelium.
Specimen S1: embryonic day 12.5; Igf2tm1Cons/Igf2tm1Cons (more )
Structure Level Pattern Image Note
TS20: ventricle cardiac muscle Present S1_left upper , S1_left lower
TS20: ventricle endocardial lining Present S1_left upper , S1_left lower
TS20: ascending aorta Present Regionally restricted S1_left lower , S1_left upper Expressed in coronary blood vessel endothelium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
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