Igf2^tm1Cons
Targeted Allele Detail

Summary

• Symbol: Igf2^tm1Cons
• Name: insulin-like growth factor 2; targeted mutation 1, Miguel Constancia
• MGI ID: MGI:6197527
• Synonyms: Igf2^fl
• Gene: Igf2 Location: Chr7:142204503-142220553 bp, - strand Genetic Position: Chr7, 87.99 cM
• Alliance: Igf2^tm1Cons page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264273
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 5 of exon 4 and a loxP-flanked neomycin resistance gene cassette was inserted 3 of exon 6. The selection cassette was removed via cre-mediated recombination leaving exons 4-6 floxed. (J:264273, J:298625)

Expression

In Mice Carrying this Mutation:

39 assay results 3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf2 Mutation: 25 strains or lines available

References

• Original: J:264273 Haley VL, et al., Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes. EMBO Mol Med. 2012 Aug;4(8):705-18
• All: 7 reference(s)