About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:179737 Takano-Maruyama M, et al., Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis. Dev Dyn. 2012 Feb;241(2):229-41
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6388551
Gene symbol: Phox2b
Gene name: paired-like homeobox 2b
Antibody: anti-Phox2b
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1A: embryonic day 10.5-11.0 (more )
Structure Level Pattern Image Note
TS18: facial ganglion Present 1A
TS18: inferior glossopharyngeal ganglion Present 1A
TS18: inferior vagus ganglion Present 1A
Specimen 1B: embryonic day 10.5-11.0; Neurog1tm1And/Neurog1tm1And (more )
Structure Level Pattern Image Note
TS18: facial ganglion Present 1B Expression in this mutant is the same as in wild-type.
TS18: inferior glossopharyngeal ganglion Present 1B Expression in this mutant is the same as in wild-type.
TS18: inferior vagus ganglion Present 1B Expression in this mutant is the same as in wild-type.
Specimen 1C: embryonic day 10.5-11.0; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2+ (more )
Structure Level Pattern Image Note
TS18: facial ganglion Present 1C Expression in this mutant is the same as in wild-type.
TS18: inferior glossopharyngeal ganglion Present 1C Expression in this mutant is the same as in wild-type.
TS18: inferior vagus ganglion Present 1C Expression in this mutant is the same as in wild-type.
Specimen 1D: embryonic day 10.5-11.0 (more )
Structure Level Pattern Image Note
TS18: facial ganglion Present 1D
TS18: inferior glossopharyngeal ganglion Present 1D
TS18: inferior vagus ganglion Present 1D
Specimen 1E: embryonic day 10.5-11.0; Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Structure Level Pattern Image Note
TS18: inferior vagus ganglion Present 1E
Specimen 1F: embryonic day 10.5-11.0; Neurog1tm1And/Neurog1+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Structure Level Pattern Image Note
TS18: inferior vagus ganglion Present 1F
Specimen 2A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: geniculate placode Present 2A
TS15: nodose placode Present 2A
TS15: petrosal placode Present 2A
Specimen 2B: embryonic day 9.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Structure Level Pattern Image Note
TS15: geniculate placode Absent 2B
TS15: nodose placode Absent 2B
TS15: petrosal placode Absent 2B
Specimen 2E: embryonic day 10.5 (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS17: nodose placode Present 2E
TS17: petrosal placode Present 2E
Specimen 2F: embryonic day 10.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS17: epibranchial placode Absent 2F The petrosal and nodose ganglia are missing in this mutant.
Specimen 2G: embryonic day 12.5 (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: inferior glossopharyngeal ganglion Present 2G
TS20: inferior vagus ganglion Present 2G
Specimen 2H: embryonic day 12.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: cranial ganglion Present Regionally restricted 2H This mutant has a complete loss of post-ganglionic neurons of the otic ganglion, as well as the placode-derived neurons of the trigeminal ganglion.
Specimen 3A: embryonic day 12.5 (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3A
TS20: otic ganglion Present 3A
Specimen 3B: embryonic day 12.5; Neurog1tm1And/Neurog1tm1And (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3B Expression in this mutant is the same as in wild-type.
TS20: otic ganglion Present 3B Expression in this mutant is the same as in wild-type.
TS20: cranial ganglion Present Regionally restricted 3B Expression is in a group of neurons that may contribute to the trigeminal ganglion.
Specimen 3C: embryonic day 12.5 (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3C
TS20: otic ganglion Present 3C
Specimen 3D: embryonic day 12.5; Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: otic ganglion Weak 3D
TS20: cranial ganglion Present Regionally restricted 3D The geniculate ganglion is missing in this mutant.
Specimen 3E: embryonic day 12.5 (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3E
TS20: otic ganglion Present 3E
Specimen 3F: embryonic day 12.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: red - Phox2b; green - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: cranial ganglion Present Regionally restricted 3F This mutant has a complete loss of post-ganglionic neurons of the otic ganglion, as well as the placode-derived neurons of the trigeminal ganglion.
Specimen 4A: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: facial ganglion Present 4A
TS20: otic ganglion Present 4A
Specimen 4B: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Pax7tm1(cre)Mrc/Pax7+ (more )
Note: Conditional mutant. Double labeled: red - Phox2b; blue - Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS20: facial ganglion Present 4B
TS20: otic ganglion Present 4B
Specimen 4C: embryonic day 9.0 (more )
Note: Double labeled: green - Phox2b; red - Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS14: petrosal placode Present 4C
Specimen 4D: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+ (more )
Note: Conditional mutant. Double labeled: blue - Phox2b; red - Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS17: petrosal placode Present 4D
Specimen 4E: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+ (more )
Note: Conditional mutant. Double labeled: red - Phox2b; blue - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS19: inferior glossopharyngeal ganglion Present 4E
TS19: migrating neural crest Present Regionally restricted 4E Expression is in cells migrating rostrally from the petrosal ganglion toward their terminal target area ventral to the geniculate ganglion.
Specimen 4F: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+ (more )
Note: Conditional mutant. Double labeled: red - Phox2b; blue - Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS20: inferior glossopharyngeal ganglion Present 4F
TS20: migrating neural crest Present Regionally restricted 4F Expression is in cells migrating rostrally from the petrosal ganglion toward their terminal target area ventral to the geniculate ganglion.
Specimen 5A: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: red - Phox2b; blue - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS17: petrosal placode Present 5A
Specimen 5B: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: red - Phox2b; blue - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS17: cranial ganglion Present 5B
Specimen 6C: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: red - Phox2b; blue - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS19: migrating neural crest Present 6C
Specimen 6D: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: red - Phox2b; blue - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS19: migrating neural crest Present 6D
Specimen 6E: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: red - Phox2b; blue - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: migrating neural crest Present 6E
Specimen 6F: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: red - Phox2b; blue - Isl1 (assay MGI:6388565).
Structure Level Pattern Image Note
TS20: migrating neural crest Absent 6F
Specimen 6G: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: blue - Phox2b; red - Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS20: inferior glossopharyngeal ganglion Present 6G
Specimen 6H: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: blue - Phox2b; red - Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS20: inferior glossopharyngeal ganglion Present 6H
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory