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Gene Expression Data
Assay Details
Assay
Reference: J:179737 Takano-Maruyama M, et al., Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis. Dev Dyn. 2012 Feb;241(2):229-41
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6388565
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: anti-Isl1
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2C: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: geniculate placode Present 2C
TS15: nodose placode Present 2C
TS15: petrosal placode Present 2C
Specimen 2D: embryonic day 9.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Structure Level Pattern Image Note
TS15: geniculate placode Present 2D Expression in this mutant is the same as in wild-type.
TS15: nodose placode Present 2D Expression in this mutant is the same as in wild-type.
TS15: petrosal placode Present 2D Expression in this mutant is the same as in wild-type.
Specimen 2E: embryonic day 10.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS17: nodose placode Present 2E
TS17: petrosal placode Present 2E
Specimen 2F: embryonic day 10.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS17: nodose placode Present 2F Expression in this mutant is the same as in wild-type.
TS17: petrosal placode Present 2F Expression in this mutant is the same as in wild-type.
Specimen 2G: embryonic day 12.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: inferior glossopharyngeal ganglion Present 2G
TS20: inferior vagus ganglion Present 2G
Specimen 2H: embryonic day 12.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: cranial ganglion Present Regionally restricted 2H The petrosal and nodose ganglia are missing in this mutant.
Specimen 3A: embryonic day 12.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3A
TS20: trigeminal ganglion Present 3A
Specimen 3B: embryonic day 12.5; Neurog1tm1And/Neurog1tm1And (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3B
TS20: cranial ganglion Present Regionally restricted 3B This mutant is missing the trigeminal ganglion. Expression is in a group of neurons that may contribute to the trigeminal ganglion.
Specimen 3C: embryonic day 12.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3C
TS20: trigeminal ganglion Present 3C
Specimen 3D: embryonic day 12.5; Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: trigeminal ganglion Present 3D
TS20: cranial ganglion Present Regionally restricted 3D The geniculate ganglion is missing in this mutant.
Specimen 3E: embryonic day 12.5 (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: facial ganglion Present 3E
TS20: vestibulo-cochlear ganglion Present 3E
Specimen 3F: embryonic day 12.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Double labeled: green - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: cranial ganglion Present Regionally restricted 3F This mutant has a complete loss of post-ganglionic neurons of the otic ganglion, as well as the placode-derived neurons of the trigeminal ganglion.
Specimen 4E: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+ (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS19: cranial ganglion Present 4E
Specimen 5A: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS17: petrosal placode Present 5A
Specimen 5B: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS17: cranial ganglion Present 5B
Specimen 6A: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: red - Isl1; blue Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS17: petrosal placode Present 6A
Specimen 6B: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: red - Isl1; blue Sox10 (assay MGI:6388619).
Structure Level Pattern Image Note
TS17: petrosal placode Present Single cells 6B
Specimen 6C: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS19: migrating neural crest Present 6C
Specimen 6D: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS19: migrating neural crest Present 6D
Specimen 6E: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2+ (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: migrating neural crest Present 6E
Specimen 6F: embryonic day 12.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Hoxa3tm1(cre)Moon/Hoxa3+, Neurog2tm1Fgu/Neurog2tm1Fgu (more )
Note: Conditional mutant. Double labeled: blue - Isl1; red - Phox2b (assay MGI:6388551).
Structure Level Pattern Image Note
TS20: migrating neural crest Absent 6F
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory