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Gene Expression Data
Assay Details
Assay
Reference: J:272619 Aydogdu N, et al., TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. Development. 2018 Nov 26;145(23):dev171827
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6385392
Gene symbol: Tbx3
Gene name: T-box 3
Antibody: Anti-Tbx3 (E-20); sc-31656
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1B E12.5: embryonic day 12.5 (more )
Note: proximal (kidney) level
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Present 1B E12.5 TBX3
TS20: ureteral mesenchyme subepithelial layer Present 1B E12.5 TBX3
Specimen 1B E14.5: embryonic day 14.5 (more )
Note: proximal (kidney) level
Structure Level Pattern Image Note
TS22: urothelium of ureter Present 1B E14.5 TBX3
TS22: ureteral mesenchyme subepithelial layer Present 1B E14.5 TBX3
Specimen 1B E16.5: embryonic day 16.5 (more )
Note: proximal (kidney) level
Structure Level Pattern Image Note
TS24: urothelium of ureter Present 1B E16.5 TBX3
TS24: ureteral mesenchyme subepithelial layer Weak 1B E16.5 TBX3
Specimen 1B E18.5: embryonic day 18.5 (more )
Note: proximal (kidney) level
Structure Level Pattern Image Note
TS26: urothelium of ureter Present 1B E18.5 TBX3
Specimen S2B E12.5: embryonic day 12.5 (more )
Note: distal (close to the bladder) level
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Strong S2B E12.5 TBX3
TS20: ureteral mesenchyme subepithelial layer Weak S2B E12.5 TBX3
Specimen S2B E13.5: embryonic day 13.5 (more )
Note: distal (close to the bladder) level
Structure Level Pattern Image Note
TS21: urothelium of ureter Strong S2B E13.5 TBX3
TS21: ureteral mesenchyme subepithelial layer Weak S2B E13.5 TBX3
Specimen S2B E14.5: embryonic day 14.5 (more )
Note: distal (close to the bladder) level
Structure Level Pattern Image Note
TS22: urothelium of ureter Strong S2B E14.5 TBX3
TS22: ureteral mesenchyme subepithelial layer Weak S2B E14.5 TBX3
Specimen S2B E16.5: embryonic day 16.5 (more )
Note: distal (close to the bladder) level
Structure Level Pattern Image Note
TS24: urothelium of ureter Strong S2B E16.5 TBX3
TS24: ureteral mesenchyme subepithelial layer Weak S2B E16.5 TBX3
Specimen S2B E18.5: embryonic day 18.5 (more )
Note: distal (close to the bladder) level
Structure Level Pattern Image Note
TS26: urothelium of ureter Strong S2B E18.5 TBX3
Specimen S3 control: embryonic day 12.5; Tbx2tm2.2Vmc/?, Tbx3tm3.2Moon/?, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: proximal (kidney) level
Structure Level Pattern Image Note
TS20: ureteral mesenchyme subepithelial layer Present S3_control TBX3
TS20: epithelial layer of ureter Strong S3_control TBX3
Specimen S3 Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl: embryonic day 12.5; Tbx2tm2.2Vmc/Tbx2tm2.2Vmc, Tbx3tm3.2Moon/Tbx3tm3.2Moon, Tbx18tm4(cre)Akis/Tbx18+, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. proximal (kidney) level
Structure Level Pattern Image Note
TS20: ureteral mesenchyme subepithelial layer Absent S3_Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl TBX3
TS20: epithelial layer of ureter Strong S3_Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl TBX3 Epithelial expression is unaffected in the conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory