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Gene Expression Data
Assay Details
Assay
Reference: J:135407 Liao J, et al., Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev Biol. 2008 Apr 15;316(2):524-37
Assay type: RNA in situ
MGI Accession ID: MGI:6385053
Gene symbol: Nkx2-6
Gene name: NK2 homeobox 6
Probe: Nkx2-6 probe3
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1P: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: secondary heart field Present 1P
TS14: branchial pouch endoderm Present 1P
Specimen 1Q: embryonic day 9.0; Tbx1tm2.2Bem/Tbx1tm2.2Bem (more )
Structure Level Pattern Image Note
TS14: secondary heart field Weak Regionally restricted 1Q Expression significantly reduced in mutant compared to wild type. No expression in caudal part of second heart field (SHF)
TS14: branchial pouch endoderm Present 1Q Expression unchanged in pharyngeal pouch endoderm.
Specimen E9.5 +/+ not shown: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: branchial arch endoderm Present
Specimen E9.5 -/- not shown: embryonic day 9.5; Tbx1tm2.2Bem/Tbx1tm2.2Bem (more )
Structure Level Pattern Image Note
TS15: branchial pouch endoderm Present Expression unchanged in pharyngeal pouch endoderm.
Specimen 4C: embryonic day 9.5; Tbx1tm2.1Bem/Tbx1+, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: secondary heart field Present 4C
Specimen 4D: embryonic day 9.5; Tbx1tm2.1Bem/Tbx1tm2.2Bem, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: secondary heart field Weak Regionally restricted 4D Authors report same changes in expression as in Tbx1-/- embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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