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Gene Expression Data
Assay Details
Assay
Reference: J:195050 Wilson CL, et al., Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Apr-May;130(4-5):272-89
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6378204
Gene symbol: Vcan
Gene name: versican
Antibody: anti-mouse versican (GAG-beta domain) (AB1033)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 7A: postnatal week 16-21; Adam17tm1.1Rain/Adam17+, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant. The fix was either 4% paraformaldehyde or Bouin's.
Structure Level Pattern Image Note
TS28: aortic valve Present Uniform 7A Dense uniform expression was detected in aortic valve cusp.
Specimen 7B: postnatal week 16-21; Adam17tm1.1Rain/Adam17+, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant. The fix was either 4% paraformaldehyde or Bouin's.
Structure Level Pattern Image Note
TS28: aortic valve Present Uniform 7B Dense uniform expression was detected in aortic valve cusp.
Specimen 7D: postnatal week 16-21; Adam17tm1.1Rain/Adam17tm1.2Rain, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant. The fix was either 4% paraformaldehyde or Bouin's.
Structure Level Pattern Image Note
TS28: aortic valve Present Non-Uniform 7D A heterogeneous expression pattern was noted in the mutant cusps. In areas with reduced staining, mesenchymal cells were aligned parallel to each other but independently of other regions of the cusp.
Specimen 7E: postnatal week 16-21; Adam17tm1.1Rain/Adam17tm1.2Rain, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant. The fix was either 4% paraformaldehyde or Bouin's.
Structure Level Pattern Image Note
TS28: aortic valve Present Non-Uniform 7E A heterogeneous expression pattern was noted in the mutant cusps. In areas with reduced staining, mesenchymal cells were aligned parallel to each other but independently of other regions of the cusp.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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