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Gene Expression Data
Assay Details
Assay
Reference: J:271100 Shen B, et al., Genetic dissection of tie pathway in mouse lymphatic maturation and valve development. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1221-30
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6314706
Gene symbol: Lyve1
Gene name: lymphatic vessel endothelial hyaluronan receptor 1
Results
Specimen 1E ICD/ICD LYVE-1: embryonic day 13.5; Tie1tm1.1Yuhe/Tie1tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:6314705).
Structure Level Pattern Image Note
TS21: lymph sac Present Regionally restricted 1E ICD/ICD Overlay , 1E ICD/ICD LYVE-1 Authors report jugular lymph sac formed normally in homozygous mutant mice.
Specimen 1E +/ICD LYVE-1: embryonic day 13.5; Tie1tm1.1Yuhe/Tie1+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: red - Lyve1; green - Pecam1 (assay MGI:6314705).
Structure Level Pattern Image Note
TS21: lymph sac Present Regionally restricted 1E +/ICD Overlay , 1E +/ICD LYVE-1
Specimen 1E +/+ LYVE-1: embryonic day 13.5 (more )
Note: Double labeled: red - Lyve1; green - Pecam1 (assay MGI:6314705).
Structure Level Pattern Image Note
TS21: lymph sac Present Regionally restricted 1E +/+ Overlay , 1E +/+ LYVE-1 Authors report jugular lymph sac formed normally in homozygous mutant mice.q
Specimen 2D ICD/ICD LYVE-1: embryonic day 15.5; Tie1tm1.1Yuhe/Tie1tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: green - Lyve1; green - Prox1 (assay MGI:6314707).
Structure Level Pattern Image Note
TS23: lymphatic system Present Regionally restricted 2D ICD/ICD Overlay , 2D ICD/ICD LYVE-1 Authors report disruption of proper formation of lymphatic network compared to that of control mice.
Specimen 2D +/ICD LYVE-1: embryonic day 15.5; Tie1tm1.1Yuhe/Tie1+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: green - Lyve1; green - Prox1 (assay MGI:6314707).
Structure Level Pattern Image Note
TS23: back skin Present Regionally restricted 2D +/ICD Overlay , 2D +/ICD LYVE1 Expression in lymphatic endothelial cells.
Specimen 2D +/+ LYVE-1: embryonic day 15.5 (more )
Note: Double labeled: green - Lyve1; green - Prox1 (assay MGI:6314707).
Structure Level Pattern Image Note
TS23: back skin Present Regionally restricted 2D +/+ LYVE-1 , 2D +/+ Overlay Expression in lymphatic endothelial cells.
Specimen 3C ICD/ICD LYVE-1: embryonic day 15.75; Tie1tm1.1Yuhe/Tie1tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Triple labeled: green - Lyve1; green - Prox1 (assay MGI:6314707); blue - Tie1 (assay MGI:6314704).
Structure Level Pattern Image Note
TS23: lymphatic system Present Regionally restricted 3C ICD/ICD LYVE-1 , 3C ICD/ICD Overlay Authors state remodeling of primary lymphatic network to form collecting vessels does not occur in homozygous mutant mice.
Specimen 3C +/ICD LYVE-1: embryonic day 15.75; Tie1tm1.1Yuhe/Tie1+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Triple labeled: green - Lyve1; green - Prox1 (assay MGI:6314707); blue - Tie1 (assay MGI:6314704).
Structure Level Pattern Image Note
TS23: lymphatic vessel Weak Regionally restricted 3C +/ICD LYVE-1 , 3C +/ICD Overlay Authors report weak expression in lymphatic vessel with strong Prox1 expression.
Specimen 4A ICD/ICD LYVE-1: embryonic day 17.5; Tie1tm1.1Yuhe/Tie1tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: lymphatic system Present Regionally restricted 4A ICD/ICD LYVE-1 Authors report disruption of remodeling of primary lymphatic network in homozygous mutant mice.
Specimen 4A +/ICD LYVE-1: embryonic day 17.5; Tie1tm1.1Yuhe/Tie1+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: gut mesentery Present Regionally restricted 4A +/ICD LYVE-1 Expression in lymphatic endothelial cells.
Specimen 4A +/+ LYVE-1: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: gut mesentery Present Regionally restricted 4A +/+ LYVE-1 Expression in lymphatic endothelial cells.
Specimen 7C Ang2-/- E15.5 LYVE-1: embryonic day 15.5; Angpt2tm1.1Yuhe/Angpt2tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: lymphatic vessel Present 7C Ang2-/- LYVE-1
Specimen 7C Ang2+/- E15.5 LYVE-1: embryonic day 15.5; Angpt2tm1.1Yuhe/Angpt2+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: lymphatic vessel Present 7C Ang2+/- LYVE-1
Specimen 7D Ang2-/- LYVE-1: embryonic day 18.5; Angpt2tm1.1Yuhe/Angpt2tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: green - Lyve1; green - Prox1 (assay MGI:6314707).
Structure Level Pattern Image Note
TS26: lymphatic vessel Present 7D Ang2-/- LYVE-1 , 7D Ang2-/- Overlay
Specimen 7D Ang2+/- LYVE-1: embryonic day 18.5; Angpt2tm1.1Yuhe/Angpt2+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant. Double labeled: green - Lyve1; green - Prox1 (assay MGI:6314707).
Structure Level Pattern Image Note
TS26: lymphatic vessel Present 7D Ang2+/- Overlay , 7D Ang2+/- LYVE-1
Specimen S1A ICD/ICD LYVE-1: embryonic day 17.5; Tie1tm1.1Yuhe/Tie1tm1.1Yuhe, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: lymphatic system Present Regionally restricted S1A ICD/ICD LYVE-1 Authors report incrased lymphatic vessel branching points in homozygous mutants compared with control mice.
Specimen S1A WT/ICD LYVE-1: embryonic day 17.5; Tie1tm1.1Yuhe/Tie1+, Tg(EIIa-cre)C5379Lmgd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: lymphatic system Present S1A WT/ICD LYVE-1
Specimen S1A WT/WT LYVE-1: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lymphatic system Present S1A WT/WT LYVE-1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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