Tie1^tm1.1Yuhe
Targeted Allele Detail

Summary

• Symbol: Tie1^tm1.1Yuhe
• Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1; targeted mutation 1.1, Yulong He
• MGI ID: MGI:6280650
• Synonyms: Tie1-ICD^Flox
• Gene: Tie1 Location: Chr4:118328388-118347046 bp, - strand Genetic Position: Chr4, 54.67 cM
• Alliance: Tie1^tm1.1Yuhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271100
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The first loxP was inserted into intron 14, and the second loxP together with neomycin-resistant gene flanked by FRT sites was inserted into intron 16. The Neo-cassette was removed using FLPeR mice, leaving exons 15 and 16 floxed. The 2 exons encode part of Tie1 intracellular domain (ICD). (J:271100)

Expression

In Mice Carrying this Mutation:

51 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tie1 Mutation: 68 strains or lines available

References

• Original: J:271100 Shen B, et al., Genetic dissection of tie pathway in mouse lymphatic maturation and valve development. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1221-30
• All: 2 reference(s)