Angpt2^tm1.1Yuhe
Targeted Allele Detail

Summary

• Symbol: Angpt2^tm1.1Yuhe
• Name: angiopoietin 2; targeted mutation 1.1, Yulong He
• MGI ID: MGI:6280652
• Synonyms: Ang2^Flox
• Gene: Angpt2 Location: Chr8:18740279-18791578 bp, - strand Genetic Position: Chr8, 10.3 cM
• Alliance: Angpt2^tm1.1Yuhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271100
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Tthe first loxP was inserted into intron 2, and the second loxP together with neomycin cassette was inserted into intron 3. The Neo-cassette was removed using FLPeR mice, leaving exons 3 floxed. (J:271100)

Expression

In Mice Carrying this Mutation:

19 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angpt2 Mutation: 47 strains or lines available

References

• Original: J:271100 Shen B, et al., Genetic dissection of tie pathway in mouse lymphatic maturation and valve development. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1221-30
• All: 5 reference(s)