Tg(tetO-Grin2b/Grin2a)#Dumas
Transgene Detail
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| Symbol: |
Tg(tetO-Grin2b/Grin2a)#Dumas |
| Name: |
transgene insertion, Theodore C Dumas |
| MGI ID: |
MGI:6281399 |
| Synonyms: |
BAc, TRE_BAc |
| Transgene: |
Tg(tetO-Grin2b/Grin2a)#Dumas Location: unknown
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| Alliance: |
Tg(tetO-Grin2b/Grin2a)#Dumas page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(tetO-Grin2b/Grin2a)#Dumas expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Grin2a (MGI:95820) |
N-terminus and transmembrane domains from Grin2b, C-terminus from Grin2a |
| mouse |
Grin2b (MGI:95821) |
N-terminus and transmembrane domains from Grin2b, C-terminus from Grin2a |
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Mutation details: This chimeric N-methyl-D-aspartate receptor (NMDAR) subunit transgene was created as follows: a tetracycline response elemet (TRE) was placed upstream of sequence coding for the extracellular N-terminus and transmembrane domains of the Grin2b peptide, fused to sequence coding for the intracellular C-terminal portion of the Grin2a peptide. When mice containing this transgene are crossed to mice expressing a tTA or rtTA transgene, expression of this allele can be switched off or on on demand through the application of tetracycline.
(J:271402)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:271402 Sanders EM, et al., Developmental modification of synaptic NMDAR composition and maturation of glutamatergic synapses: matching postsynaptic slots with receptor pegs. Biol Bull. 2013 Feb;224(1):1-13 |
| All: |
2 reference(s) |
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Analysis Tools
