Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(tetO-Grin2b/Grin2a)#Dumas
Name:	transgene insertion, Theodore C Dumas
MGI ID:	MGI:6281399
Synonyms:	BAc, TRE_BAc
Transgene:	Tg(tetO-Grin2b/Grin2a)#Dumas  Location: unknown
Alliance:	Tg(tetO-Grin2b/Grin2a)#Dumas page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(tetO-Grin2b/Grin2a)#Dumas expresses 2 genes Transgene expresses: Organism Expressed Gene Note mouse Grin2a (MGI:95820) N-terminus and transmembrane domains from Grin2b, C-terminus from Grin2a mouse Grin2b (MGI:95821) N-terminus and transmembrane domains from Grin2b, C-terminus from Grin2a   Mutation details: This chimeric N-methyl-D-aspartate receptor (NMDAR) subunit transgene was created as follows: a tetracycline response elemet (TRE) was placed upstream of sequence coding for the extracellular N-terminus and transmembrane domains of the Grin2b peptide, fused to sequence coding for the intracellular C-terminal portion of the Grin2a peptide. When mice containing this transgene are crossed to mice expressing a tTA or rtTA transgene, expression of this allele can be switched off or on on demand through the application of tetracycline. (J:271402)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:271402 Sanders EM, et al., Developmental modification of synaptic NMDAR composition and maturation of glutamatergic synapses: matching postsynaptic slots with receptor pegs. Biol Bull. 2013 Feb;224(1):1-13
All:	2 reference(s)