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Grin2b Gene Detail
Summary
  • Symbol
    Grin2b
  • Name
    glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • Synonyms
    GluN2B, GluRepsilon2, Nmdar2b, NMDAR2B, NR2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95821
    NCBI Gene: 14812
  • Gene Overview
    MyGene.info: GRIN2B
Location & Maps
more
  • Sequence Map
    Chr6:135713233-136173511 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      460279 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 66.38 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    GRIN2B, glutamate ionotropic receptor NMDA type subunit 2B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GRIN2B, glutamate ionotropic receptor NMDA type subunit 2B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIEE27, GluN2B, hNR3, MRD6, NMDAR2B, NR2B
  • Links
    NCBI Gene ID: 2904
    neXtProt AC: NX_Q13224

  • Chr Location
    12p12; chr12:13537337-13982002 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human GRIN2B associations

Human Disease Mouse Models
       Epileptic Encephalopathy, Early Infantile, 27; EIEE27   OMIM: 616139
Mental Retardation, Autosomal Dominant 6; MRD6   OMIM: 613970
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 12 alleles in 13 genetic backgrounds
    7 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impairments in suckling, in hippocampal long term depression, and in pattern formation of trigeminal nucleus sensory afferent terminals. Mutants die shortly after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016356 VEGA Gene Model | MGI Sequence Detail 460279 C57BL/6J ±  kb
transcript OTTMUST00000039337 VEGA | MGI Sequence Detail 24060 Not Applicable  
polypeptide OTTMUSP00000017581 VEGA | MGI Sequence Detail 1482 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6076 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008247 glutamate receptor ionotropic, NMDA 2B
  • InterPro Domains
    IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 27
    Genomic 1
    cDNA 22
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10259, MGD-MRK-12900, MGI:2141680
References
more
  • Summaries
    All 190
    Developmental Gene Expression 31
    Gene Ontology 54
    Phenotypes 60
  • Earliest
    J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
  • Latest
    J:228732 Berg JM, et al., JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron. 2015 Dec 16;88(6):1173-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory