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Grin2b Gene Detail
Summary
  • Symbol
    Grin2b
  • Name
    glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • Synonyms
    GluN2B, GluRepsilon2, Nmdar2b, NMDAR2B, NR2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95821
    NCBI Gene: 14812
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:135690231-136150509 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 66.38 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14419 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95821
 protein coding gene Chr6:135690219-136150658 (-)
129S1/SvImJ ENSMUSG00200030896
 protein coding gene Chr6:133175519-133634161 (-)
A/J ENSMUSG00195028087
 protein coding gene Chr6:132028647-132493645 (-)
AKR/J ENSMUSG00220032421
 protein coding gene Chr6:130253085-130721724 (-)
BALB/cJ ENSMUSG00180032114
 protein coding gene Chr6:132121324-132586993 (-)
C3H/HeJ ENSMUSG00175029821
 protein coding gene Chr6:132048912-132513886 (-)
C57BL/6NJ ENSMUSG00215026605
 protein coding gene Chr6:132313202-132773761 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028994
 protein coding gene Chr6:133702578-134169528 (-)
CAST/EiJ ENSTCUG00005034169
 protein coding gene Chr6:132998571-133458382 (-)
CBA/J ENSMUSG00210015782
 protein coding gene Chr6:132067313-132532254 (-)
DBA/2J ENSMUSG00185020855
 protein coding gene Chr6:132763571-133228508 (-)
FVB/NJ ENSMUSG00205024880
 protein coding gene Chr6:131202453-131667163 (-)
JF1/MsJ ENSUMUG00000033402
 protein coding gene Chr6:131529631-131990285 (-)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190005944
 protein coding gene Chr6:132601775-133066720 (-)
NZO/HlLtJ ENSMUSG00225007094
 protein coding gene Chr6:136838265-137298795 (-)
PWK/PhJ ENSLUMG00010040768
 protein coding gene Chr6:130582812-131043872 (-)
SPRET/EiJ ENSMSPG00010030380
 protein coding gene Chr6:134409440-134854040 (-)
WSB/EiJ ENSIUOG00005040807
 protein coding gene Chr6:132878175-133337236 (-)



Homology
more
  • Human Ortholog
    GRIN2B, glutamate ionotropic receptor NMDA type subunit 2B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIN2B, glutamate ionotropic receptor NMDA type subunit 2B
  • Synonyms
    DEE27, EIEE27, GluN2B, hNR3, MRD6, NMDAR2B, NR2B, NR3
  • Links
    NCBI Gene ID: 2904
    UniProt: Q13224

  • Chr Location
    12p13.1; chr12:13437942-13982134 (-)  GRCh38
Human Diseases
more
  • Diseases
    9 with human GRIN2B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 11 alleles in 12 genetic backgrounds
    21 phenotypes from multigenic genotypes
    123 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impairments in suckling, hippocampal long term depression, and pattern formation of trigeminal nucleus sensory afferent terminals. Mutants die shortly after birth. Kinase-dead mutants display ant-depressive behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    212
  • GO References
    77
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    941
  • Tissues
    110
  • cDNA Data
    23
  • Literature Summary
    74
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030209 Ensembl Gene Model | MGI Sequence Detail 460279 C57BL/6J ±  kb
    transcript ENSMUST00000053880 Ensembl | MGI Sequence Detail 24060 Not Applicable  
    polypeptide ENSMUSP00000062284 Ensembl | MGI Sequence Detail 1482 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 23
      Primer pair 6
      Other 4
      Antibodies 12

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10259, MGD-MRK-12900, MGI:2141680
    References
    more
    • Summaries
      All 411
      Developmental Gene Expression 74
      Gene Ontology 77
      Phenotypes 123
    • Earliest
      J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
    • Latest
      J:390257 Gao S, et al., Mll5 haploinsufficiency attenuates microglial phagocytosis through dysregulated TREM2-SGK3-GSK3beta signaling and recapitulates ASD-like behaviors in mice. Nat Commun. 2026 Apr 17;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory