Grin2b
Gene Detail

Symbol Name ID

Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) MGI:95821

Synonyms

GluRepsilon2, Nmdar2b, NMDAR2B, NR2B

Feature Type

protein coding gene

Genetic Map

Chromosome 6

66.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr6:135731627-136173511 bp, - strand From VEGA annotation of GRCm38   441885 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: N-methyl-D-aspartate receptor 2A
Gene Tree: Grin2b

Human homologs

Human Homolog		GRIN2B, glutamate receptor, ionotropic, N-methyl D-aspartate 2B
NCBI Gene ID		2904
neXtProt AC		NX_Q13224
Human Synonyms		GluN2B, hNR3, MRD6, NMDAR2B, NR2B
Human Chr (Location)		12p12; chr12:13714410-14133022 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GRIN2B

Alleles and phenotypes

All alleles(12) : Targeted(12)
 

Homozygotes for targeted null mutations exhibit impairments in suckling, in hippocampal long term depression, and in pattern formation of trigeminal nucleus sensory afferent terminals. Mutants die shortly after birth.

 

Gene Ontology (GO) classifications

All GO classifications: (108 annotations)

Process	associative learning, behavioral fear response, ...
Component	cell junction, cell surface, ...
Function	beta-catenin binding, calcium channel activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (25 records)
Data Summary: Results (123)    Tissues (77)    Images (9)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	31
Western blot	36
RT-PCR	54

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(1) cDNA(22) Primer pair(3) Other(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016356 (Evidence)
Ensembl Gene Model	ENSMUSG00000030209 (Evidence)
Entrez Gene	14812 (Evidence)
UniGene	436649
DFCI	TC1589668, TC1605853, TC1655752
DoTS	DT.101159503, DT.101363018, DT.55166772, DT.55207404, DT.87048813
NIA Mouse Gene Index	U027967
Consensus CDS Project	CCDS20648.1
International Mouse Knockout Project Status	Grin2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016356	VEGA Gene Model | MGI Sequence Detail	441885	C57BL/6J
transcript	OTTMUST00000039337	VEGA | MGI Sequence Detail	5245	Not Applicable
polypeptide	OTTMUSP00000017581	VEGA | MGI Sequence Detail	1482	Not Applicable

All sequences(43) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(3) : SNPs(3468 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR001638	Extracellular solute-binding protein, family 3
InterPro	IPR018884	Glutamate [NMDA] receptor, epsilon subunit, C-terminal
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008247	glutamate [NMDA] receptor subunit epsilon-2

References

(Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:193909 Hill TC, et al., LTP-induced long-term stabilization of individual nascent dendritic spines. J Neurosci. 2013 Jan 9;33(2):678-86
All references(162)

Other accession IDs

MGD-MRK-10259, MGD-MRK-12900, MGI:2141680