About   Help   FAQ
Grin2b
Gene Detail
Symbol

Name
ID
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
MGI:95821
Synonyms
GluN2B, GluRepsilon2, Nmdar2b, NMDAR2B, NR2B
Feature Type
protein coding gene
Genetic Map
Chromosome 6
66.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr6:135713232-136173511 bp, - strand
From VEGA annotation of GRCm38

  460280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GRIN2B
Protein SuperFamily: N-methyl-D-aspartate receptor 2A
Gene Tree: Grin2b

Human
homologs
GRIN2B, glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2904
neXtProt AC: NX_Q13224

Human Synonyms: EIEE27, GluN2B, hNR3, MRD6, NMDAR2B, NR2B

Human Chr (Location): 12p12; chr12:13537337-13982002 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GRIN2B

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(14)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit impairments in suckling, in hippocampal long term depression, and in pattern formation of trigeminal nucleus sensory afferent terminals. Mutants die shortly after birth.
 
Interactions
Grin2b interacts with 325 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (111 annotations)
Process action potential, associative learning, ...
Component cell junction, cell surface, ...
Function beta-catenin binding, calcium channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (123)    Tissues (79)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 31
Western blot 36
RT-PCR 54
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GRIN2B    NEW 
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(22) Primer pair(3) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016356 (Evidence)
Ensembl Gene Model ENSMUSG00000030209 (Evidence)
Entrez Gene 14812 (Evidence)
UniGene 436649
DFCI TC1589668, TC1605853, TC1655752
DoTS DT.101159503, DT.101363018, DT.55166772, DT.55207404, DT.87048813
NIA Mouse Gene Index U027967
Consensus CDS Project CCDS20648.1
International Mouse Phenotyping Consortium Status Grin2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016356 VEGA Gene Model | MGI Sequence Detail 460280 C57BL/6J ±  kb
transcript OTTMUST00000039337 VEGA | MGI Sequence Detail 23640 Not Applicable 
polypeptide OTTMUSP00000017581 VEGA | MGI Sequence Detail 1482 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(16) UniProt(8)
Polymorphisms
RFLP(3) : SNPs within 2kb(6146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008247 glutamate receptor ionotropic, NMDA 2B
References
(Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:222552 Tindi JO, et al., ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization. J Neurosci. 2015 Jun 17;35(24):8986-96
All references(188)
Other
accession IDs
MGD-MRK-10259, MGD-MRK-12900, MGI:2141680

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory