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Grin2b
Gene Detail
 Symbol
Name
ID
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
MGI:95821
Synonyms GluN2B, GluRepsilon2, Nmdar2b, NMDAR2B, NR2B
Feature Type protein coding gene
Genetic Map
Chromosome 6
66.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr6:135713232-136173511 bp, - strand
From VEGA annotation of GRCm38

  460280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: N-methyl-D-aspartate receptor 2A
Gene Tree: Grin2b

Human
homologs
Human Homolog GRIN2B, glutamate receptor, ionotropic, N-methyl D-aspartate 2B
NCBI Gene ID 2904
neXtProt AC  NX_Q13224
Human Synonyms  GluN2B, hNR3, MRD6, NMDAR2B, NR2B
Human Chr (Location)  12p12; chr12:13560750-13980088 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRIN2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impairments in suckling, in hippocampal long term depression, and in pattern formation of trigeminal nucleus sensory afferent terminals. Mutants die shortly after birth.
 
Interactions
Grin2b interacts with 326 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (109 annotations)
Process action potential, associative learning, ...
Component cell junction, cell surface, ...
Function beta-catenin binding, calcium channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (123)    Tissues (79)    Images (9)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 31
Western blot 36
RT-PCR 54
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(22) Primer pair(3) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016356 (Evidence)
Ensembl Gene ModelENSMUSG00000030209 (Evidence)
Entrez Gene14812 (Evidence)
UniGene436649
DFCITC1589668, TC1605853, TC1655752
DoTSDT.101159503, DT.101363018, DT.55166772, DT.55207404, DT.87048813
NIA Mouse Gene IndexU027967
Consensus CDS ProjectCCDS20648.1
International Mouse Knockout Project StatusGrin2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016356 VEGA Gene Model | MGI Sequence Detail 460280 C57BL/6J ±  kb
transcript OTTMUST00000039337 VEGA | MGI Sequence Detail 23640 Not Applicable 
polypeptide OTTMUSP00000017581 VEGA | MGI Sequence Detail 1482 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(10) UniProt(6)
Polymorphisms RFLP(3) : SNPs within 2kb(6146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR001638 Extracellular solute-binding protein, family 3
InterPro IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008247 glutamate receptor ionotropic, NMDA 2B
References (Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All references(179)
Other
accession IDs
MGD-MRK-10259, MGD-MRK-12900, MGI:2141680

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory