Rr29<tm1.1Tshir> Targeted Allele Detail MGI Mouse (MGI:6143996)

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Rr29^tm1.1Tshir
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Summary

Symbol:	Rr29^tm1.1Tshir
Name:	regulatory region 29; targeted mutation 1.1, Toshihiko Shiroishi
MGI ID:	MGI:6143996
Synonyms:	MFCS1^-
Gene:	Rr29 Location: unknown Genetic Position: Chr5, Syntenic
Alliance:	Rr29^tm1.1Tshir page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:96968
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Modified regulatory region, Null/knockout)
Mutation:		Intergenic deletion
		Rr29^tm1.1Tshir involves 1 genes/genome features (Lmbr1) View all
		Mutation details: A neomycin resistance gene cassette replaced the MFCS1 (Rr29) Shh enhancer in intron 5 of the Lmbr1 gene. (J:96968)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Rr29 Mutation:	2 strains or lines available

References

Original:	J:96968 Sagai T, et al., Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Development. 2005 Feb;132(4):797-803
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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