Rr29 Other Genome Feature Detail

Summary

• Symbol
  Rr29
• Name
  regulatory region 29
• Synonyms
  MFCS1, ZRS

• Feature Type
  enhancer
• IDs
  MGI:5499537

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• Rr29 and Rr29 point mutations chr5:29519899-29520257 (GRCm39) J:316049 seq: chr5:29519879-29520665 (GRCm39)

• Genetic Map
  Chromosome 5, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  29 phenotypes from 10 alleles in 12 genetic backgrounds
  5 phenotypes from multigenic genotypes
  2 images
  22 phenotype references
  

• All Mutations and Alleles
  23
• Chemically induced (ENU)
  8
• Endonuclease-mediated
  7
• Spontaneous
  1
• Targeted
  7
• Genomic Mutations
  1 involving Rr29
• Find Mice (IMSR)
  2 strains or lines available

Mice lacking the MFCS1 enhancer of Shh exhibit oligodactyly.

References

• Summaries
  All 23

  Phenotypes 22
• Earliest
  J:31035 Knudsen TB, et al., The role of morphogenetic cell death during abnormal limb-bud outgrowth in mice heterozygous for the dominant mutation Hemimelia-extra toe (Hmx). J Embryol Exp Morphol. 1981 Oct;65 Suppl:289-307
• Latest
  J:257759 Mouri K, et al., Enhancer adoption caused by genomic insertion elicits interdigital Shh expression and syndactyly in mouse. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1021-1026