Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Srebf2tm1Jdh
Name:	sterol regulatory element binding factor 2; targeted mutation 1, Jay D Horton
MGI ID:	MGI:5907035
Synonyms:	Srebf-2flox
Gene:	Srebf2  Location: Chr15:82031455-82089580 bp, + strand  Genetic Position: Chr15, 38.49 cM
Alliance:	Srebf2tm1Jdh page

Germline Transmission:	Earliest citation of germline transmission: J:241873
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: The targeting vector contains a loxP site inserted into the promoter region 660 bp upstream of exon 1 and a loxP site followed by a FRT-flanked neomycin cassette inserted into intron 1. (J:241873)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Srebf2 Mutation:	76 strains or lines available

Original:	J:241873 Rong S, et al., Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice. Elife. 2017 Feb 28;6:e25015
All:	2 reference(s)