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Gene Expression Data
Assay Details
Assay
Reference: J:203006 Zhuang S, et al., Expression of Isl1 during mouse development. Gene Expr Patterns. 2013 Dec;13(8):407-12
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5695107
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 8.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS13: foregut diverticulum endoderm Present 1A
TS13: outflow tract Present 1A
TS13: umbilical cord Present 1A Expressed in the umbilical cord and surrounding mesenchyme.
TS13: branchial arch mesenchyme Present Regionally restricted 1A Expressed in pharyngeal mesoderm dorsal to the heart tube.
Specimen 1B: embryonic day 9.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS15: foregut epithelium Present 1B
TS15: outflow tract Present 1B
TS15: umbilical cord Present 1B Expressed in the umbilical cord and surrounding mesenchyme.
TS15: branchial arch mesenchyme Present Regionally restricted 1B Expressed in pharyngeal mesoderm dorsal to the heart tube.
Specimen 1C: embryonic day 10.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS17: branchial arch mesenchyme Strong Regionally restricted 1C Expressed in pharyngeal mesoderm dorsal to the heart tube.
TS17: umbilical cord Strong Regionally restricted 1C Expressed in the umbilical cord and surrounding mesenchyme.
TS17: foregut epithelium Strong Regionally restricted 1C Expressed in foregut endoderm.
TS17: cranial ganglion Strong 1C
TS17: dorsal root ganglion Strong 1C
TS17: forebrain Strong 1C
TS17: midbrain Strong 1C
TS17: outflow tract Strong 1C
TS17: sinus venosus Strong 1C
TS17: future spinal cord Strong Regionally restricted 1C Expressed in spinal motor neurons.
TS17: hindlimb bud Strong Regionally restricted 1C Expressed in the posterior.
Specimen 1D: embryonic day 11.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS19: branchial arch mesenchyme Strong Regionally restricted 1D Expressed in pharyngeal mesoderm dorsal to the heart tube.
TS19: umbilical cord Strong Regionally restricted 1D Expressed in the umbilical cord and surrounding mesenchyme.
TS19: cranial ganglion Strong 1D
TS19: dorsal root ganglion Strong 1D
TS19: forebrain Strong 1D
TS19: foregut epithelium Strong 1D
TS19: midbrain Strong 1D
TS19: outflow tract Strong 1D
TS19: sinus venosus Strong 1D
TS19: future spinal cord Strong Regionally restricted 1D Expressed in spinal motor neurons.
TS19: hindlimb bud Strong Regionally restricted 1D Expressed in the posterior.
Specimen 1E: embryonic day 12.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS20: hindlimb Ambiguous Regionally restricted 1E Downregulated expression in the posterior hindlimb.
Specimen 1F: embryonic day 15.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS23: hindlimb Present Regionally restricted 1F Expressed in the posterior hindlimb.
TS23: telencephalon Present Regionally restricted 1F Expressed in the basal forebrain.
TS23: cranial ganglion Present 1F
TS23: diencephalon Present 1F
TS23: dorsal root ganglion Present 1F
TS23: midbrain Present 1F
TS23: hindbrain Present Regionally restricted 1F Expressed in the motor neurons.
TS23: spinal cord Present Regionally restricted 1F Expressed in the motor neurons.
TS23: cranium Present Regionally restricted 1F Expressed in cranial skeletal structures.
TS23: body wall mesenchyme Present Regionally restricted 1F Expressed in the muscles of the body wall.
Specimen 1G: embryonic day 15.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS23: telencephalon Present Regionally restricted 1G Expressed in the basal forebrain.
TS23: hindbrain Present Regionally restricted 1G Expressed in the motor neurons.
TS23: spinal cord Present Regionally restricted 1G Expressed in the motor neurons.
TS23: midbrain Present 1G
Specimen 1G': embryonic day 15.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS23: telencephalon Present Regionally restricted 1G' Expressed in the basal forebrain.
TS23: hindbrain Present Regionally restricted 1G' Expressed in the motor neurons.
TS23: spinal cord Present Regionally restricted 1G' Expressed in the motor neurons.
TS23: facial ganglion Present 1G'
TS23: trigeminal ganglion Present 1G'
TS23: vestibulo-cochlear ganglion Present 1G'
Specimen 1H: embryonic day 15.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS23: cervico-thoracic ganglion Present 1H
TS23: outflow tract Present 1H
TS23: superior cervical ganglion Present 1H
TS23: thymus primordium Present 1H
Specimen 1I: embryonic day 15.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS23: cardiac ganglion Present 1I
TS23: sinoatrial node Present 1I
Specimen 1J: embryonic day 15.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS23: adrenal medulla Present 1J
TS23: dorsal root ganglion Present 1J
TS23: sympathetic ganglion Present Regionally restricted 1J Expressed in the prevertebral sympathetic chain.
Specimen 1K: embryonic day 15.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS23: duodenum Present 1K
TS23: esophagus Present 1K
TS23: pancreas Present 1K
TS23: stomach pyloric region Present 1K
Specimen 2A: embryonic day 9.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS15: future midbrain Present Regionally restricted 2A Expressed in subdomains of the outer mantle layer.
Specimen 2B: embryonic day 9.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS15: future hindbrain Present Regionally restricted 2B Expressed in the ventral hindbrain.
TS15: Rathke's pouch Present 2B
TS15: trigeminal preganglion Present 2B
Specimen 2C: embryonic day 9.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS15: future hindbrain Present Regionally restricted 2C Expressed in the ventral hindbrain.
TS15: 1st branchial arch mesenchyme Present Regionally restricted 2C Expressed in the mesoderm core.
TS15: 2nd branchial arch mesenchyme Present Regionally restricted 2C Expressed in the mesoderm core.
TS15: branchial pouch Present 2C
TS15: foregut epithelium Present 2C
Specimen 2D: embryonic day 9.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS15: future hindbrain Present Regionally restricted 2D Expressed in the ventral hindbrain.
TS15: foregut epithelium Present 2D
TS15: outflow tract Present 2D
TS15: thyroid primordium Present 2D
Specimen 2E: embryonic day 9.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS15: lung Present 2E
TS15: sinus venosus Present 2E
TS15: tracheal diverticulum epithelium Present 2E
Specimen 2F: embryonic day 11.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS19: midbrain mantle layer Present 2F
Specimen 2G: embryonic day 11.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS19: diencephalon Present 2G
TS19: midbrain mantle layer Present 2G
Specimen 2H: embryonic day 11.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS19: midbrain Present Regionally restricted 2H Expressed in the trigeminal motor nucleus.
TS19: diencephalon Present 2H
Specimen 2I: embryonic day 11.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS19: telencephalon Present Regionally restricted 2I Expressed in the mantle layer of basal forebrain.
TS19: Rathke's pouch Present 2I
TS19: accessory nerve Present 2I
TS19: acoustic ganglion Present 2I
TS19: diencephalon Present 2I
TS19: facial ganglion Present 2I
TS19: hindbrain Present 2I
TS19: trigeminal ganglion Present 2I
TS19: inner ear Present Regionally restricted 2I Expressed in the ventral and dorsal pole of otic vesicle.
TS19: future spinal cord Present Regionally restricted 2I Expressed in the spinal motor neurons.
Specimen 2J: embryonic day 11.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS19: arytenoid swelling pre-cartilage condensation Present 2J
TS19: outflow tract Present 2J
TS19: sympathetic ganglion Present 2J
TS19: trachea epithelium Present 2J
Specimen 2K: embryonic day 11.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS19: interatrial septum Present 2K
TS19: sinoatrial node Present 2K
TS19: sinus venosus Present 2K
TS19: trachea mesenchyme Present Regionally restricted 2K Expressed in the mesenchyme ventral to the trachea.
Specimen 2L: embryonic day 11.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS19: dorsal root ganglion Present 2L
TS19: pancreas primordium Present 2L
TS19: sympathetic ganglion Present 2L
TS19: umbilical artery Present 2L
TS19: stomach Present Regionally restricted 2L Expressed in the distal-middle part.
TS19: pancreas primordium mesenchyme Present Regionally restricted 2L Expressed in the surrounding mesenchyme.
TS19: mesenteric vein Present Regionally restricted 2L Expressed in the superior mesenteric vein.
Specimen 2M: embryonic day 11.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS19: pancreas primordium Present 2M
TS19: pancreas primordium mesenchyme Present Regionally restricted 2M Expressed in the surrounding mesenchyme.
TS19: stomach Present Regionally restricted 2M Expressed in the distal-middle part.
Specimen 3A: embryonic day 13.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS21: accessory nerve Present 3A
TS21: diencephalon Present 3A
TS21: facial ganglion Present 3A
TS21: glossopharyngeal ganglion Present 3A
TS21: hindbrain Present 3A
TS21: inner ear Present 3A
TS21: trigeminal ganglion Present 3A
TS21: vagus ganglion Present 3A
TS21: vestibulo-cochlear ganglion Present 3A
TS21: telencephalon Present Regionally restricted 3A Expressed in the basal forebrain (caudate nucleus).
Specimen 3B: embryonic day 13.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS21: accessory nerve Present 3B
TS21: diencephalon Present 3B
TS21: facial ganglion Present 3B
TS21: glossopharyngeal ganglion Present 3B
TS21: inner ear Present 3B
TS21: trigeminal ganglion Present 3B
TS21: vagus ganglion Present 3B
TS21: vestibulo-cochlear ganglion Present 3B
TS21: telencephalon Present Regionally restricted 3B Expressed in the basal forebrain (caudate nucleus).
Specimen 3C: embryonic day 13.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS21: glossopharyngeal ganglion Present 3C
TS21: retina Present 3C
TS21: trigeminal ganglion Present 3C
TS21: vagus ganglion Present 3C
Specimen 3D: embryonic day 13.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS21: carotid artery Present 3D
TS21: dorsal root ganglion Present 3D
TS21: sympathetic ganglion Present 3D
TS21: thymus primordium Present 3D
TS21: thyroid gland Present 3D
TS21: ultimobranchial body Present 3D
TS21: spinal cord Present Regionally restricted 3D Expressed in spinal motor neurons.
TS21: trachea epithelium Present Regionally restricted 3D Expressed in ventral tracheal epithelium.
TS21: trachea mesenchyme Present Regionally restricted 3D Expressed in arytenoid swelling.
Specimen 3D inset: embryonic day 13.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS21: carotid artery Present 3D inset
Specimen 3E: embryonic day 13.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS21: arch of aorta Present 3E
Specimen 3F: embryonic day 13.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS21: outflow tract pulmonary component Present 3F Expressed in the right ventricular outlet.
TS21: sinoatrial node Present 3F
TS21: main bronchus mesenchyme Present Regionally restricted 3F Expressed in the mesenchyme lateral to the left and right main bronchi.
Specimen 3G: embryonic day 13.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS21: interatrial septum Present 3G
TS21: paracardiac ganglion Present 3G
TS21: sympathetic ganglion Present 3G
TS21: main bronchus mesenchyme Present Regionally restricted 3G Expressed in the mesenchyme lateral to the left main bronchus.
Specimen 3H: embryonic day 13.5; Isl1tm3Sev/Isl1+ (more )
Structure Level Pattern Image Note
TS21: adrenal gland Present Regionally restricted 3H Expressed in the medulla of the adrenal gland.
TS21: stomach Present Regionally restricted 3H Expressed in the middle part.
TS21: dorsal meso-esophagus Present 3H
TS21: lesser omentum Present 3H
TS21: sympathetic ganglion Present 3H
TS21: pancreas Present Regionally restricted 3H Expressed in the pancreatic islets.
TS21: umbilical artery Present Regionally restricted 3H Expressed in umbilical artery and surrounding mesenchyme.
Specimen not shown: postnatal; Isl1tm3Sev/Isl1+ (more )
Note: Early postnatal life.
Structure Level Pattern Image Note
TS28: outflow tract Present
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory