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Gene Expression Data
Assay Details
Assay
Reference: J:70796 Yang W, et al., Impaired motor coordination in mice that lack punc. Mol Cell Biol. 2001 Sep;21(17):6031-43
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5643751
Gene symbol: Igdcc3
Gene name: immunoglobulin superfamily, DCC subclass, member 3
Reporter: lacZ
Direct Detection
Results
Specimen not shown - het: embryonic day 8.5; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS13: embryo Absent
Specimen not shown - hom: embryonic day 8.5; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS13: embryo Absent
Specimen 4A: embryonic day 9.5; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS15: forelimb bud Strong 4A
TS15: future hindbrain Strong 4A
TS15: future midbrain Strong 4A
TS15: future spinal cord Strong 4A
TS15: hindlimb ridge Strong 4A
Specimen 4B: embryonic day 10.5; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS17: forebrain Strong Regionally restricted 4B Expression is confined to the ventral domain.
TS17: future spinal cord Strong Regionally restricted 4B Expression is confined to the ventral domain.
TS17: hindbrain Strong Regionally restricted 4B Expression is confined to the ventral domain.
TS17: midbrain Strong Regionally restricted 4B Expression is confined to the ventral domain.
TS17: forelimb bud Present Non-Uniform 4B There is some restriction of expression to the anterior domain.
TS17: hindlimb bud Present Non-Uniform 4B There is some restriction of expression to the anterior domain.
TS17: 1st branchial arch Present 4B
Specimen 4B': embryonic day 10.5; Igdcc3tm1Sms/Igdcc3+ (more )
Note: transverse section.
Structure Level Pattern Image Note
TS17: diencephalon Present 4B'
TS17: telencephalon Present 4B'
TS17: hindbrain Present Regionally restricted 4B' Expression present in the metencephalon.
Specimen 4D: embryonic day 11.5; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS19: midbrain Present 4D
TS19: dorsal root ganglion Present 4D Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
TS19: tail future spinal cord Present 4D Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
TS19: forelimb bud Present Regionally restricted 4D Expression is concentrated anteriorly and proximally. The lacZ expression levels observed in homs in this tissue are twice the expression levels seen in hets.
TS19: hindlimb bud Present Regionally restricted 4D Expression is concentrated anteriorly and proximally. The lacZ expression levels observed in homs in this tissue are twice the expression levels seen in hets.
Specimen not shown - L allele: embryonic day 11.5; Igdcc3tm1.1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS19: midbrain Present
TS19: dorsal root ganglion Present
TS19: tail future spinal cord Present
TS19: forelimb bud Present
TS19: hindlimb bud Present
Specimen 4E: embryonic day 11.5; Igdcc3tm1Sms/Igdcc3tm1Sms (more )
Structure Level Pattern Image Note
TS19: midbrain Present 4E
TS19: dorsal root ganglion Present 4E Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
TS19: tail future spinal cord Present 4E Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
TS19: forelimb bud Present Regionally restricted 4E Expression is concentrated anteriorly and proximally. The lacZ expression levels observed in homs in this tissue are twice the expression levels seen in hets.
TS19: hindlimb bud Present Regionally restricted 4E Expression is concentrated anteriorly and proximally. The lacZ expression levels observed in homs in this tissue are twice the expression levels seen in hets.
Specimen not shown: embryonic day 11.5; Igdcc3tm1Sms/Igdcc3tm1Sms (more )
Note: The authors did not specify whether the animals were homs or hets.
Structure Level Pattern Image Note
TS19: inner ear epithelium Present Expression is present in otic epithelium.
Specimen 4F: embryonic day 12.5; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS20: midbrain Present 4F
TS20: dorsal root ganglion Present 4F
TS20: tail spinal cord Present 4F
TS20: forelimb Present Regionally restricted 4F Expression is concentrated anteriorly and proximally.
TS20: hindlimb Present Regionally restricted 4F Expression is concentrated anteriorly and proximally.
Specimen 4G: embryonic day 13.5; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS21: forebrain Strong Regionally restricted 4G Expression is present in dorsal forebrain.
TS21: cerebellum Strong 4G
TS21: trigeminal ganglion Strong 4G
TS21: dorsal root ganglion Present Non-Uniform 4G Expression is present posteriorly.
TS21: tail spinal cord Present 4G
Specimen 4H: embryonic day 13.5; Igdcc3tm1.1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS21: forebrain Strong Regionally restricted 4H Expression is present in dorsal forebrain.
TS21: cerebellum Strong 4H
TS21: trigeminal ganglion Strong 4H
TS21: dorsal root ganglion Present 4H
TS21: tail spinal cord Present 4H
Specimen 4I: embryonic day 14.5; Igdcc3tm1Sms/Igdcc3+ (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS22: dorsal root ganglion Weak Non-Uniform 4I
TS22: brain Present 4I
Specimen 4J: embryonic day 15.5; Igdcc3tm1Sms/Igdcc3+ (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS23: dorsal root ganglion Weak Non-Uniform 4J Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
TS23: brain Present 4J
Specimen 4K: embryonic day 15.5; Igdcc3tm1Sms/Igdcc3tm1Sms (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS23: dorsal root ganglion Strong Uniform 4K Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
TS23: brain Present 4K
Specimen 4L: embryonic day 15.5; Igdcc3tm1.1Sms/Igdcc3+ (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS23: dorsal root ganglion Weak Non-Uniform 4L
TS23: brain Present 4L
Specimen 4M: embryonic day 17.5; Igdcc3tm1Sms/Igdcc3+ (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS25: brain Present 4M
Specimen not shown - het: embryonic day 17.5; Igdcc3tm1Sms/Igdcc3+ (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS25: inner ear Present
Specimen not shown - hom: embryonic day 17.5; Igdcc3tm1Sms/Igdcc3tm1Sms (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS25: brain Present
TS25: inner ear Present
Specimen 4N: embryonic day 18.5; Igdcc3tm1Sms/Igdcc3+ (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS26: brain Present 4N
Specimen not shown - het: embryonic day 18.5; Igdcc3tm1Sms/Igdcc3+ (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS26: inner ear Present
Specimen not shown - hom: embryonic day 18.5; Igdcc3tm1Sms/Igdcc3tm1Sms (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS26: brain Present
TS26: inner ear Present
Specimen 4O: postnatal day 0; Igdcc3tm1Sms/Igdcc3+ (more )
Note: embryo hemisected prior to staining
Structure Level Pattern Image Note
TS27: cerebellum Present Non-Uniform 4O Expression is strongest in the anterior domain.
Specimen 5A: postnatal adult; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS28: cerebellar cortex Present 5A Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
Specimen 5B: postnatal adult; Igdcc3tm1.1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS28: hippocampus CA2 Present 5B
TS28: main olfactory bulb Present 5B
Specimen 5C: postnatal adult; Igdcc3tm1Sms/Igdcc3tm1Sms (more )
Structure Level Pattern Image Note
TS28: cerebellar cortex Strong 5C Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
Specimen 5D: postnatal adult; Igdcc3tm1.1Sms/Igdcc3tm1.1Sms (more )
Structure Level Pattern Image Note
TS28: cerebellar cortex Present 5D
Specimen not shown: postnatal adult; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS28: dorsal root ganglion Absent No staining above background seen.
TS28: heart Absent No staining above background seen.
TS28: liver Absent No staining above background seen.
TS28: lung Absent No staining above background seen.
TS28: metanephros Absent No staining above background seen.
TS28: spinal cord Absent No staining above background seen.
TS28: spleen Absent No staining above background seen.
TS28: testis Absent No staining above background seen.
TS28: thymus Absent No staining above background seen.
Specimen 5E: postnatal adult; Igdcc3tm1.1Sms/Igdcc3tm1.1Sms (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present Single cells 5E Expression is present in the Bergmann glia.
Specimen 5F left: postnatal adult; Igdcc3tm1.1Sms/Igdcc3tm1.1Sms (more )
Note: Double labeled: blue - Igdcc3; brown - Gfap (assay MGI:5644967).
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present Single cells 5F left Expression is present in the Bergmann glia.
Specimen 5F right: postnatal adult; Igdcc3tm1.1Sms/Igdcc3tm1.1Sms (more )
Note: Double labeled: blue - Igdcc3; brown - Gfap (assay MGI:5644967).
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present Single cells 5F right Expression is present in the Bergmann glia.
Specimen 5G: postnatal adult; Igdcc3tm1Sms/Igdcc3+ (more )
Structure Level Pattern Image Note
TS28: cochlear ganglion Moderate 5G Expression is present in neurons. Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
TS28: organ of Corti Weak Regionally restricted 5G Expression is present in support cells.
Specimen 5H: postnatal adult; Igdcc3tm1Sms/Igdcc3tm1Sms (more )
Structure Level Pattern Image Note
TS28: cochlear ganglion Moderate 5H Expression is present in neurons. Unexpectedly, the lacZ expression levels observed in homs are more than twice the expression levels seen in hets.
TS28: organ of Corti Weak Regionally restricted 5H Expression is present in support cells.
Specimen 5I: postnatal adult; Igdcc3tm1Sms/Igdcc3tm1Sms (more )
Structure Level Pattern Image Note
TS28: cochlear ganglion Moderate Single cells 5I Expression is present in neurons.
Specimen 5J: postnatal adult; Igdcc3tm1Sms/Igdcc3tm1Sms (more )
Structure Level Pattern Image Note
TS28: organ of Corti Weak Single cells 5J Expression is present in pillar cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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