Tmigd3 MGI Mouse Gene Detail - MGI:5604098 - transmembrane and immunoglobulin domain containing 3

Symbol

Tmigd3
Name

transmembrane and immunoglobulin domain containing 3

Feature Type

protein coding gene
IDs

MGI:5604098
NCBI Gene: 69296
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:105778219-105831358 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, Syntenic

SNPs within 2kb

1324 from dbSNP Build 142
Strain Annotations

20

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_5604098	protein coding gene	Chr3:105778174-105831360 (+)
129S1/SvImJ	ENSMUSG00200034486	protein coding gene	Chr3:102362539-102430971 (+)
A/J	ENSMUSG00195024585	protein coding gene	Chr3:102783015-102851662 (+)
AKR/J	ENSMUSG00220027674	protein coding gene	Chr3:101154951-101223312 (+)
BALB/cJ	ENSMUSG00180015891	protein coding gene	Chr3:102728208-102796603 (+)
C3H/HeJ	ENSMUSG00175026576	protein coding gene	Chr3:102263264-102331908 (+)
C57BL/6NJ	ENSMUSG00215027190	protein coding gene	Chr3:103035469-103103910 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025478	protein coding gene	Chr3:99903078-99952362 (+)
CAST/EiJ	ENSTCUG00005019609	protein coding gene	Chr3:102994380-103062878 (+)
CBA/J	ENSMUSG00210007183	protein coding gene	Chr3:102885251-102953869 (+)
DBA/2J	ENSMUSG00185021411	protein coding gene	Chr3:103369433-103437806 (+)
FVB/NJ	ENSMUSG00205016483	protein coding gene	Chr3:101939206-102007657 (+)
JF1/MsJ	ENSUMUG00000002363	protein coding gene	Chr3:102111545-102179904 (+)
LP/J	ENSMUSG00230013337	protein coding gene	Chr3:105290438-105358867 (+)
NOD/ShiLtJ	ENSMUSG00190030845	protein coding gene	Chr3:103574222-103642611 (+)
NOD/ShiLtJ	ENSMUSG00190031056	protein coding gene	Chr3:103589202-103627428 (+)
NZO/HlLtJ	ENSMUSG00225018908	protein coding gene	Chr3:107771269-107841047 (+)
PWK/PhJ	ENSLUMG00010025271	protein coding gene	Chr3:102182730-102251433 (+)
SPRET/EiJ	ENSMSPG00010030995	protein coding gene	Chr3:102375128-102441566 (+)
WSB/EiJ	ENSIUOG00005004506	protein coding gene	Chr3:102900234-102968576 (+)

Human Ortholog

TMIGD3, transmembrane and immunoglobulin domain containing 3

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMIGD3, transmembrane and immunoglobulin domain containing 3
Synonyms

AD026
Links

HGNC:51375

NCBI Gene ID: 57413

UniProt: P0DMS9
Chr Location

1p13.2; chr1:111483348-111563962 (-) GRCh38

MGI Vertebrate Homology

Tmigd3 stringent orthology
1 human;1 mouse;1 rat;6 zebrafish
HCOP

vertebrate homology predictions: TMIGD3
Gene Tree

Tmigd3

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotypes from multigenic genotypes
7 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Transgenic

1
Genomic Mutations

2 involving Tmigd3
Find Mice (IMSR)

6 strains or lines available

Male mice homozygous for a knock-out allele are fertile and exhibit normal testis gross appearance, normal testis and epididymis histology, and normal sperm morphology and motility.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

4

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

43
RefSeq

3
UniProt

4
CCDS

CCDS38582.1, CCDS51036.1

Ensembl

ENSMUSG00000074344 (Evidence)
NCBI Gene

69296

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074344	Ensembl Gene Model \| MGI Sequence Detail	53140	C57BL/6J	± kb
transcript	ENSMUST00000010279	Ensembl \| MGI Sequence Detail	900	Not Applicable
polypeptide	ENSMUSP00000010279	Ensembl \| MGI Sequence Detail	209	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000038988 transmembrane domain-containing protein TMIGD3

(term hierarchy)
InterPro Domains

IPR000466 Adenosine A3 receptor

IPR001634 Adenosine receptor

IPR050671 CD300 family immune receptors

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR062123 TMIGD3, C-terminal domain

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All nucleic 4

cDNA 4

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MGI:5909982

Summaries

All 22

Diseases 1

Gene Ontology 4

Phenotypes 7
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:370030 Ogawa Y, et al., CRISPR/Cas9-mediated genome editing reveals seven testis-enriched transmembrane glycoproteins dispensable for male fertility in mice. Andrology. 2025 Jul;13(5):1251-1260

TSS for Tmigd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31085	Chr3:105778201-105778211 (+)	-13 bp
Tssr31086	Chr3:105778214-105778228 (+)	2 bp
Tssr31087	Chr3:105799348-105799368 (+)	21,139 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24