Tg(CD2-Fyn/Lck)1Rza
Transgene Detail
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| Symbol: |
Tg(CD2-Fyn/Lck)1Rza |
| Name: |
transgene insertion 1, Rose Zamoyska |
| MGI ID: |
MGI:4946118 |
| Synonyms: |
FU-Lcktg |
| Transgene: |
Tg(CD2-Fyn/Lck)1Rza Location: unknown
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| Alliance: |
Tg(CD2-Fyn/Lck)1Rza page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CD2-Fyn/Lck)1Rza expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Fyn (MGI:95602) |
Transgene codes for a fusion protein of Fyn and Lck. |
| mouse |
Lck (MGI:96756) |
Transgene codes for a fusion protein of Fyn and Lck. |
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Mutation details: The transgene expresses a cDNA encoding a fusion protein constructed from the Fyn unique domain (aa 1-85) with the Lck SH3, SH2 and kinase domains, under the control of the human CD2 promoter. A C-terminal V5 epitope tag was added to the construct.
(J:168430)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:168430 Salmond RJ, et al., Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas. Blood. 2011 Jan 6;117(1):108-17 |
| All: |
1 reference(s) |
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Analysis Tools
