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Gene Expression Data
Assay Details
Assay
Reference: J:145849 Wu X, et al., Bmp7 expression and null phenotype in the urogenital system suggest a role in re-organization of the urethral epithelium. Gene Expr Patterns. 2009 Apr;9(4):224-30
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5449354
Gene symbol: Bmp7
Gene name: bone morphogenetic protein 7
Reporter: lacZ
Direct Detection
Results
Specimen 1B +/-: embryonic day 11.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS19: reproductive system Present 1B +/- Expression was detected in the urethral plate and genital mesenchyme.
TS19: urinary system Present 1B +/- Expression was detected in the urethral plate and genital mesenchyme.

Specimen 1B -/-: embryonic day 11.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS19: embryo Present 1B -/-

Specimen 1C: embryonic day 11.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS19: tail Present 1C
TS19: urorectal septum Present 1C
TS19: body wall Present Regionally restricted 1C Expression was detected in the ventral ectoderm of the body wall.
TS19: embryo ectoderm Present Regionally restricted 1C Expression was detected in the ventral ectoderm of the body wall.
TS19: genital swelling of genital tubercle Present Regionally restricted 1C Expression was detected in the mesenchyme of the genital swellings.

Specimen 1D: embryonic day 11.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS19: tail Present 1D
TS19: urorectal septum Present 1D
TS19: body wall Present Regionally restricted 1D Expression was detected in the ventral ectoderm of the body wall.
TS19: embryo ectoderm Present Regionally restricted 1D Expression was detected in the ventral ectoderm of the body wall.
TS19: genital swelling of genital tubercle Present Regionally restricted 1D Expression was detected in the mesenchyme of the genital swellings.

Specimen 2A: embryonic day 12.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS20: urethral plate Present 2A
TS20: reproductive system Present Regionally restricted 2A Expression was detected in genital mesenchyme.

Specimen 2C +/-: embryonic day 12.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS20: urethral plate Present 2C +/-
TS20: reproductive system Present Regionally restricted 2C +/- Expression was detected in mesenchyme adjacent to the urethral plate.

Specimen 2C -/-: embryonic day 12.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS20: urethral plate Present Regionally restricted 2C -/- Expression was detected in the urethral epithelium at the surface of the groove in the urethral plate in the mutant.

Specimen 2E: embryonic day 12.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS20: metanephros Present 2E
TS20: urethral plate Present 2E
TS20: urorectal septum Present 2E
TS20: reproductive system Present Regionally restricted 2E Expression was detected in mesenchyme adjacent to the urethral plate.
TS20: trunk Present Regionally restricted 2E Expression was detected in the ventral ectoderm.

Specimen 2F: embryonic day 12.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS20: urorectal septum Present 2F

Specimen 2G: embryonic day 12.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS20: urethral plate Present 2G
TS20: urorectal septum Present 2G

Specimen 2H: embryonic day 12.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS20: urethral plate Present 2H
TS20: reproductive system Present Regionally restricted 2H Expression was detected in genital mesenchyme adjacent to the urethral plate.

Specimen 2I: embryonic day 12.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS20: metanephros Present 2I
TS20: urethral plate Present 2I
TS20: urorectal septum Present 2I
TS20: reproductive system Present Regionally restricted 2I Expression was detected in mesenchyme adjacent to the urethral plate.
TS20: trunk Present Regionally restricted 2I Expression was detected in the ventral ectoderm.

Specimen 2J: embryonic day 12.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS20: urinary system Present 2J

Specimen 2K: embryonic day 12.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS20: genital tubercle Present Regionally restricted 2K Expression was detected in genital mesenchyme adjacent to the urethral plate (higher magnification in inset).

Specimen 2L: embryonic day 12.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS20: genital tubercle Present Regionally restricted 2L Expression was detected in genital mesenchyme adjacent to the urethral plate (higher magnification in inset).

Specimen 3A: embryonic day 13.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS21: urethral plate Present 3A
TS21: reproductive system Present Regionally restricted 3A Expression was detected in the genital mesenchyme.

Specimen 3C: embryonic day 13.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS21: genital tubercle Present Regionally restricted 3C Expression was detected in the ventral and dorsal genital mesenchyme.
TS21: urorectal septum Weak 3C

Specimen 3D: embryonic day 13.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS21: genital tubercle Present Regionally restricted 3D Expression was detected in the ventral and dorsal genital mesenchyme.
TS21: urorectal septum Weak 3D

Specimen 3E: embryonic day 13.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS21: body wall mesenchyme Present Regionally restricted 3E Expression was detected in the lateral mesenchyme of the body wall.

Specimen 3F: embryonic day 13.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS21: distal urethral epithelium Strong Graded 3F Expression was in a gradient with the strongest expression in the distal urethral epithelium and the weakest at the urorectal septum.
TS21: urorectal septum Weak Graded 3F Expression was in a gradient with the strongest expression in the distal urethral epithelium and the weakest at the urorectal septum.

Specimen 3G: embryonic day 13.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS21: distal urethral epithelium Strong Graded 3G Expression was in a gradient with the strongest expression in the distal urethral epithelium and the weakest at the urorectal septum.
TS21: urorectal septum Weak Graded 3G Expression was in a gradient with the strongest expression in the distal urethral epithelium and the weakest at the urorectal septum.
TS21: urethral plate Present 3G

Specimen 3H: embryonic day 13.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS21: urethral plate Present 3H

Specimen 3I: embryonic day 13.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS21: reproductive system Present 3I

Specimen 3J: embryonic day 13.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS21: reproductive system Present 3J

Specimen 3K: embryonic day 13.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS21: urethral plate Absent 3K Expression was lost in the proximal part of the urethral plate.
TS21: distal urethral epithelium Present 3K
TS21: genital tubercle Present Regionally restricted 3K Expression was detected in a broad lateral domain of the genital tubercle mesenchyme.

Specimen 3L: embryonic day 13.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS21: urethral plate Absent 3L Expression was lost in the medial part of the urethral plate.
TS21: distal urethral epithelium Present 3L
TS21: genital tubercle Present Regionally restricted 3L Expression was detected in a broad lateral domain of the genital tubercle mesenchyme.

Specimen 4D: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: body wall Present 4D
TS25: rectum Present 4D
TS25: urethra of male Present 4D
TS25: urogenital sinus Present 4D
TS25: male reproductive system Present Regionally restricted 4D Expression was detected in the bulbourethral and preputial glands.
TS25: genital tubercle of male Present Regionally restricted 4D Expression was detected in the corpus cavernosum.
TS25: bladder Absent 4D

Specimen 4D inset: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: ductus deferens Present 4D inset
TS25: testis Absent 4D inset

Specimen 4E: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: body wall Strong 4E
TS25: rectum Strong 4E
TS25: urethra of male Strong 4E
TS25: anal region Strong Regionally restricted 4E Expression was detected in the cloaca.
TS25: male reproductive system Strong Regionally restricted 4E Expression was detected in the preputial gland.

Specimen 4F: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: rectum Strong 4F
TS25: genital tubercle of male Strong Regionally restricted 4F Expression was detected in the mesenchyme of the corpus cavernosum at the ventral side of the genital tubercle.
TS25: anal region Strong Regionally restricted 4F Expression was detected in the cloaca.

Specimen 5A: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Note: Double labeled: blue - Bmp7 reporter; yellow - Krt14 (assay MGI:5449722).
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5A Expression was detected in the urethral epithelium.

Specimen 5B: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5B Expression was detected in the urethral epithelium.

Specimen 5C: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Note: Double labeled: blue - Bmp7 reporter; yellow - Krt14 (assay MGI:5449722).
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5C Expression was detected in the urethral epithelium.

Specimen 5D: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5D Expression was detected in the urethral epithelium and mesenchyme. Expression in the mesenchyme is concentrated surrounding the ventral epithelial fusion.
TS25: male reproductive system Present Regionally restricted 5D Expression was detected in the epithelium of the preputial glands.

Specimen 5E: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: penis Present Regionally restricted 5E Expression was detected in the corpus cavernosum.

Specimen 5F: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: penis Present Regionally restricted 5F Expression was detected in the corpus cavernosum.

Specimen 5G: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Note: Double labeled: blue - Bmp7 reporter; yellow - Krt14 (assay MGI:5449722).
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5G Expression was detected in the urethral epithelium.

Specimen 5H: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5H Expression was detected in the urethral epithelium.
TS25: penis Present Regionally restricted 5H Expression was detected in the corpus cavernosum.
TS25: male reproductive system Present Regionally restricted 5H Expression was detected in the epithelium of the preputial glands.
TS25: intestine Present Regionally restricted 5H Expression was detected in the intestinal crypts.

Specimen 5I: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: penis Present Regionally restricted 5I Expression was detected in the corpus cavernosum.

Specimen 5J: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Note: Double labeled: blue - Bmp7 reporter; yellow - Krt14 (assay MGI:5449722).
Structure Level Pattern Image Note
TS25: rectum Present 5J
TS25: urethra of male Present 5J

Specimen 5K: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5K Expression was detected in the urethral mesenchyme.
TS25: rectum Present Regionally restricted 5K Expression was detected in the mesenchyme of the rectum.

Specimen 5L: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: rectum Present 5L

Specimen 5N: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Note: Double labeled: blue - Bmp7 reporter; yellow - Krt14 (assay MGI:5449722).
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5N Expression was detected in the mesenchyme of the urethra.
TS25: rectum Present 5N

Specimen 5O: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5O Expression was detected in the mesenchyme of the urethra.
TS25: rectum Present 5O

Specimen 5P: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Note: Double labeled: blue - Bmp7 reporter; yellow - Krt14 (assay MGI:5449722).
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5P Expression was detected in the mesenchyme of the urethra.
TS25: rectum Present 5P

Specimen 5R: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5R Expression was detected in the mesenchyme of the urethra.
TS25: rectum Present 5R

Specimen Fgi. 5S: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: urethra of male Present Regionally restricted 5S Expression was detected in the mesenchyme of the urethra.
TS25: anal region Strong Regionally restricted 5S Expression was detected in the cloaca.
TS25: rectum Present 5S

Specimen 5T: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Note: Double labeled: blue - Bmp7 reporter; yellow - Krt14 (assay MGI:5449722).
Structure Level Pattern Image Note
TS25: anal region Present Regionally restricted 5T Expression was detected in the cloaca.
TS25: urethra of male Present Regionally restricted 5T Expression was detected in the urethral epithelium.

Specimen 6C: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: Mullerian tubercle Present 6C
TS25: oviduct Present 6C
TS25: rectum Present 6C
TS25: urethra of female Present 6C
TS25: uterine horn Present 6C
TS25: vagina Present 6C
TS25: genital tubercle of female Present Regionally restricted 6C Expression was detected in the corpus cavernosum.
TS25: female reproductive system Present Regionally restricted 6C Expression was detected in the preputial gland.
TS25: bladder Absent 6C
TS25: ovary Absent 6C

Specimen 6C inset: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: urethra of female Present 6C inset

Specimen 6D: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: Mullerian tubercle Present 6D
TS25: body wall Present 6D
TS25: metanephros Present 6D
TS25: rectum Present 6D
TS25: urethra of female Present 6D
TS25: uterine horn Present 6D
TS25: vagina Present 6D
TS25: genital tubercle of female Present Regionally restricted 6D Expression was detected in the mesenchyme of the genital tubercle.
TS25: bladder Absent 6D

Specimen 6E: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: Mullerian tubercle Present 6E
TS25: rectum Present 6E
TS25: ovary Absent 6E

Specimen 7B: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: urethra of female Present Regionally restricted 7B Expression was detected in the epithelium of the urethra.
TS25: intestine Present Regionally restricted 7B Expression was detected in the intestinal crypts.
TS25: female reproductive system Present Regionally restricted 7B Expression was detected in the preputial glands.

Specimen 7E: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: urethra of female Present Regionally restricted 7E Expression was detected in the epithelium and mesenchyme of the urethra.
TS25: rectum Present Regionally restricted 7E Expression was detected in the mesenchyme of the rectum.
TS25: genital tubercle of female Present Regionally restricted 7E Expression was detected in the corpus cavernosum.

Specimen 7F: embryonic day 17.5; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS25: rectum Present Regionally restricted 7F Expression was detected in the mesenchyme of the rectum.
TS25: genital tubercle of female Present Regionally restricted 7F Expression was detected in the corpus cavernosum.

Specimen 7G: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: urethra of female Present Regionally restricted 7G Expression was detected in the epithelium and mesenchyme of the urethra.
TS25: rectum Present Regionally restricted 7G Expression was detected in the mesenchyme of the rectum.

Specimen 7H: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: urethra of female Present Regionally restricted 7H Expression was detected in the epithelium and mesenchyme of the urethra.
TS25: rectum Present Regionally restricted 7H Expression was detected in the mesenchyme of the rectum.

Specimen 7I: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: urethra of female Present Regionally restricted 7I Expression was detected in the epithelium and mesenchyme of the urethra.

Specimen 7J: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: anal region Present Regionally restricted 7J Expression was detected in the cloaca.

Specimen 7L: embryonic day 17.5; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS25: genital tubercle of female Present Regionally restricted 7L Expression was detected in the corpus cavernosum.
TS25: glans clitoris Present 7L

Specimen 8A: postnatal day 0; Bmp7tm2Rob/Bmp7+ (more )
Structure Level Pattern Image Note
TS27: urethra of male Present Regionally restricted 8A Expression was detected in the urethral meatus.

Specimen 8B: postnatal day 0; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS27: anal region Strong Regionally restricted 8B Expression was detected in the cloacal area.

Specimen 8C: postnatal day 0; Bmp7tm2Rob/Bmp7tm2Rob (more )
Structure Level Pattern Image Note
TS27: anal region Strong Regionally restricted 8C Expression was detected in the cloacal area.


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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory